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Review

A comprehensive overview on osteoporosis and its risk factors

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Pages 2029-2049 | Published online: 06 Nov 2018

References

  • BouillonRBurckhardtPChristiansenCConsensus development conference: prophylaxis and treatment of osteoporosisAm J Med1991901071101986575
  • KanisJAMeltonLJChristiansenCJohnstonCCKhaltaevNThe diagnosis of osteoporosisJ Bone Miner Res19949113711417976495
  • ConsensusNDevelopment panel on osteoporosis: prevention, diagnosis and therapyJAMA200128578579511176917
  • HolroydCCooperCDennisonEEpidemiology of osteoporosisBest Pract Res Clin Endocrinol Metab20082267168519028351
  • LaneNEEpidemiology, etiology, and diagnosis of osteoporosisAm J Obstet Gynecol2006194S3S1116448873
  • RoubenoffRKehayiasJJThe meaning and measurement of lean body massNutr Rev1991491631752046978
  • JohnellOKanisJAAn estimate of the worldwide prevalence and disability associated with osteoporotic fracturesOsteoporos Int2006171726173316983459
  • KepleyALNishiyamaKKZhouBDifferences in bone quality and strength between Asian and Caucasian young menOsteoporos Int20172854955827638138
  • LeiSChenYXiongDLiLDengHEthnic difference in osteoporosis-related phenotypes and its potential underlying genetic determinationJ Musculoskelet Neuronal Interact200663616675888
  • CauleyJADefining ethnic and racial differences in osteoporosis and fragility fracturesClin Orthop Relat Res20114691891189921431462
  • SugimotoTSatoMDehleFCBrnabicAJWestonABurgeRLifestyle-related metabolic disorders, osteoporosis, and fracture risk in Asia: a systematic reviewValue Health Reg Issues20169495627881259
  • MeltonLJThe prevalence of osteoporosisJ Bone Miner Res199712176917719383680
  • KlibanskiAAdams-CampbellLBassfordTLOsteoporosis prevention, diagnosis, and therapyJAMA200128578579511176917
  • CooperCCampionGMeltonLRHip fractures in the elderly: a world-wide projectionOsteoporos Int199222852891421796
  • MeltonLHip fractures: a worldwide problem today and tomorrowBone199314188442996
  • SterlingRSGender and race/ethnicity differences in hip fracture incidence, morbidity, mortality, and functionClin Orthop Relat Res20114691913191821161737
  • HaentjensPMagazinerJColón-EmericCSMeta-analysis: excess mortality after hip fracture among older women and menAnn Intern Med201015238039020231569
  • HawkesWGWehrenLOrwigDHebelJRMagazinerJGender differences in functioning after hip fractureJ Gerontol A Biol Sci Med Sci20066149549916720747
  • MeltonLJKanSHFryeMAWahnerHWO’FallonWMRiggsBLEpidemiology of vertebral fractures in womenAm J Epidemiol1989129100010112784934
  • CooperCO’NeillTSilmanAEVOS GroupThe epidemiology of vertebral fracturesBone1993148997
  • OglesbyAKMinshallMEShenWXieSSilvermanSLThe impact of incident vertebral and non-vertebral fragility fractures on health-related quality of life in established postmenopausal osteoporosis: results from the teriparatide randomized, placebo-controlled trial in postmenopausal womenJ Rheumatol2003301579158312858462
  • NevittMCEttingerBBlackDMThe association of radiographically detected vertebral fractures with back pain and function: a prospective studyAnn Intern Med19981287938009599190
  • FelsenbergDSilmanALuntMIncidence of vertebral fracture in Europe: results from the European Prospective Osteoporosis Study (EPOS)J Bone Miner Res20021771672411918229
  • FurlleipnlszAVertebral fractures and mortality in older womenArch Intern Med19991591215122010371229
  • LicataAGeusensPFlowersKSeemanERisk of new vertebral fracture in the year following a fractureJAMA2001285332032311176842
  • DuanYParfittAMSeemanEVertebral bone mass, size, and volumetric density in women with spinal fracturesJ Bone Miner Res1999141796180210491228
  • VegaEGhiringhelliGMautalenCRey ValzacchiGScagliaHZylbersteinCBone mineral density and bone size in men with primary osteoporosis and vertebral fracturesCalcif Tissue Int1998624654699541527
  • BriggsAGreigAWarkJThe vertebral fracture cascade in osteoporosis: a review of aetiopathogenesisOsteoporos Int20071857558417206492
  • NellansKWKowalskiEChungKCThe epidemiology of distal radius fracturesHand Clinics20122811312522554654
  • ShinEJupiterJCurrent concepts in the management of distal radius fracturesActa Chir Orthop Traumatol Cech20077423324617877939
  • BrogrenEPetranekMAtroshiIIncidence and characteristics of distal radius fractures in a southern Swedish regionBMC Musculoskeletal Disorders200784817540030
  • O’neillTCooperCFinnJUK Colles’ Fracture StudyIncidence of distal forearm fracture in British men and womenOsteoporos Int20011255555811527052
  • NevittMCCummingsSRType of fall and risk of hip and wrist fractures: the study of osteoporotic fracturesJ Am Geriatr Soc199341122612348227898
  • OmslandTKAhmedLAGrønskagAMore forearm fractures among urban than rural women: the NOREPOS study based on the Tromsø study and the HUNT studyJ Bone Miner Res20112685025621061241
  • CuddihyMTGabrielSECrowsonCO’FallonWMeltonLJForearm fractures as predictors of subsequent osteoporotic fracturesOsteoporos Int1999946947510624452
  • MallminHLjunghallSPerssonINaessénTKrusemoUBBergströmRFracture of the distal forearm as a forecaster of subsequent hip fracture: a population-based cohort study with 24 years of follow-upCalcif Tissue Int1993522692728467406
  • LauritzenJBSchwarzPMcNairPLundBTransbølIRadial and humeral fractures as predictors of subsequent hip, radial or humeral fractures in women, and their seasonal variationOsteoporos Int199331331378481589
  • GouldingARisk factors for fractures in normally active children and adolescentsDalyRMPetitMAOptimizing Bone Mass and StrengthBaselKarger Publishers2007102120
  • TeitelbaumSLBone resorption by osteoclastsScience20002891504150810968780
  • ZaidiMSkeletal remodeling in health and diseaseNat Med20071379180117618270
  • CohenJEWakefieldCECohnRJNutritional interventions for survivors of childhood cancerCochrane Database Syst Rev20168CD009678
  • LevisSLagariVSThe role of diet in osteoporosis prevention and managementCurr Osteoporos Rep20121029630223001895
  • ShinSSungJJoungHA fruit, milk and whole grain dietary pattern is positively associated with bone mineral density in Korean healthy adultsEur J Clin Nutr20156944244825351648
  • ChanRChanDWooJA cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong KongJ Nutr Health Aging20131775776524154648
  • MareszKProper calcium use: vitamin K2 as a promoter of bone and cardiovascular healthIntegr Med (Encinitas)2015143439
  • WatanabeDHottaMIchiharaAOsteomalacia, severe thoracic deformities and respiratory failure in a young woman with anorexia nervosaIntern Med20155492993425876575
  • SommerIErkkilaATJarvinenRAlcohol consumption and bone mineral density in elderly womenPublic Health Nutr20131670471222800300
  • NachtigallMJNazemTGNachtigallRHGoldsteinSROsteoporosis risk factors and early life-style modifications to decrease disease burden in womenClin Obstet Gynecol20135665065324100599
  • ZhangXYuZYuMQuXAlcohol consumption and hip fracture riskOsteoporos Int20152653154225266483
  • PaccouJEdwardsMHWardKRelationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumptionBone20157812212925959415
  • Ortego-CentenoNMunoz-TorresMJodarEHernandez-QueroJJurado-DuceAde la Higuera Torres-PucholJEffect of tobacco consumption on bone mineral density in healthy young malesCalcif Tissue Int1997604965009164822
  • KlineJTangALevinBSmoking, alcohol and caffeine in relation to two hormonal indicators of ovarian age during the reproductive yearsMaturitas20169211512227621248
  • KrallEADawson-HughesBSmoking and bone loss among postmenopausal womenJ Bone Miner Res199163313381858519
  • KrallEADawson-HughesBSmoking increases bone loss and decreases intestinal calcium absorptionJ Bone Miner Res1999142152209933475
  • JensenJChristiansenCRødbroPCigarette smoking, serum estrogens, and bone loss during hormone-replacement therapy early after menopauseN Engl J Med19853139739754047104
  • JickHPorterJMorrisonARelation between smoking and age of natural menopause: report from the Boston Collaborative Drug Surveillance Program, Boston University Medical CenterThe Lancet197730913541355
  • TalmageRVMobleyHCalcium homeostasis: reassessment of the actions of parathyroid hormoneGen Comp Endocrinol20081561818160068
  • NormanAWVitamin D metabolism and calcium absorptionAm J Med197967989998229729
  • BrotCJorgensenNSorensenOThe influence of smoking on vitamin D status and calcium metabolismEur J Clin Nutr19995392092610602348
  • KoCHChanRLSiuWSDeteriorating effect on bone metabolism and microstructure by passive cigarette smoking through dual actions on osteoblast and osteoclastCalcif Tissue Int20159638940025694359
  • BunceCMBrownGHewisonMVitamin D and hematopoiesisTrends Endocrinol Metab1997824525118406812
  • FerrariSBonjourJPRizzoliRThe vitamin D receptor gene and calcium metabolismTrends Endocrinol Metab1998925926518406281
  • WaltersMRNewly identified actions of the vitamin D endocrine systemEndocr Rev1992137197641333949
  • MorrisonNAYeomanRKellyPJEismanJAContribution of transacting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcinProc Natl Acad Sci U S A199289666566691353882
  • HausslerMRWhitfieldGKHausslerCAThe nuclear vitamin D receptor: biological and molecular regulatory properties revealedJ Bone Miner Res1998133254499525333
  • KurabayashiTMatsushitaHTomitaMAssociation of vitamin D and estrogen receptor gene polymorphism with the effects of longterm hormone replacement therapy on bone mineral densityJ Bone Miner Metab20042224124715108066
  • MorrisonNAQiJCTokitaAPrediction of bone density from vitamin D receptor allelesNature19943672842878161378
  • SainzJVan TornoutJMLoroMLSayreJRoeTFGilsanzVVitamin D–receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descentN Engl J Med199733777829211676
  • GennariLBecheriniLMasiLVitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution to bone mineral densityJ Clin Endocrinol Metab1998839399449506753
  • LiuYZLiuYJReckerRRDengHWMolecular studies of identification of genes for osteoporosis: the 2002 updateJ Endocrinol200317714719612740006
  • Dawson-HughesBHarrisSSFinneranSCalcium absorption on high and low calcium intakes in relation to vitamin D receptor genotypeJ Clin Endocrinol Metab199580365736618530616
  • WillingMSowersMAronDBone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interactionJ Bone Miner Res1998136957059556070
  • PouresmaeiliFJJAzargashbESamangoueeSAssociation between vitamin D receptor gene BsmI polymorphism and bone mineral density in a population of 146 Iranian womenCell J2013157882
  • ChengJBelgraderPZhouXMaquatLEIntrons are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundanceMol Cell Biol199414631763258065363
  • NesicDChengJMaquatLESequences within the last intron function in RNA 3′-end formation in cultured cellsMol Cell Biol199313335933697684497
  • SpectorTKeenRArdenNInfluence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in BritainBMJ1995310135713607787536
  • GrossCEccleshallTRMalloyPJVillaMLMarcusRFeldmanDThe presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American womenJ Bone Miner Res199611185018558970885
  • AraiHMiyamotoKITaketaniYA vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese womenJ Bone Miner Res1997129159219169350
  • ZajíčkováKOfkováIBahbouhRKřepelováAVitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone massPhysiol Res20025150150912470203
  • MitraSDesaiMKhatkhatayMIVitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian womenMaturitas200655273516464547
  • AraiHMiyamotoKIYoshidaMThe polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor geneJ Bone Miner Res2001161256126411450701
  • YamamotoHMiyamotoKILiBThe caudal-related homeodo-main protein Cdx-2 regulates vitamin D receptor gene expression in the small intestineJ Bone Miner Res1999142402479933478
  • YoonKRutledgeSBuenagaRFRodanGACharacterization of the rat osteocalcin gene: stimulation of promoter activity by 1, 25-dihydroxyvitamin D3Biochemistry198827852185263265336
  • TokitanAMatsumotoHMorrisonNAVitamin D receptor alleles, bone mineral density and turnover in premenopausal Japanese womenJ Bone Miner Res199611100310098797122
  • GennariLMerlottiDDe PaolaVEstrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE reviewAm J Epidemiol200516130732015692074
  • KorachKSEstrogen receptor knock-out mice: molecular and endocrine phenotypesJ Soc Gynecol Investig20007S16S17
  • VidalOLindbergMKHollbergKEstrogen receptor specificity in the regulation of skeletal growth and maturation in male miceProc Natl Acad Sci U S A2000975474547910805804
  • WindahlSVidalOAnderssonGGustafssonJ-AOhlssonCIncreased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ−/− miceJ Clin Invest199910489590110510330
  • LindbergMAlataloSHalleenJMohanSGustafssonJAOhlssonCEstrogen receptor specificity in the regulation of the skeleton in female miceJ Endocrinol200117122923611691642
  • JuradaSMarcJPreželjJKocijančičAKomelRCodon 325 sequence polymorphism of the estrogen receptor α gene and bone mineral density in postmenopausal womenJ Steroid Biochem Mol Biol200178152011530279
  • OngphiphadhanakulBChanprasertyothinSPayattikulPAssociation of a T262C transition in exon 1 of estrogen-receptor-α gene with skeletal responsiveness to estrogen in post-menopausal womenJ Endocrinol Invest20012474975511765043
  • OngphiphadhanakulBChanprasertyothinSPayattikulPAssociation of a G2014A transition in exon 8 of the estrogen receptor-α gene with postmenopausal osteoporosisOsteoporos Int2001121015101911846326
  • LangdahlBLLøkkeECarstensMStenkjaerLLEriksenEFA TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are notJ Bone Miner Res2000152222223011092403
  • KobayashiTSugimotoTKobayashiAChiharaKVitamin D receptor genotype is associated with cortical bone loss in Japanese patients with primary hyperparathyroidismEndocr J1998451231259625456
  • KobayashiNFujinoTShiroganeTEstrogen receptor α polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogenMaturitas20024119320111886765
  • MizunumaHHosoiTOkanoHEstrogen receptor gene polymorphism and bone mineral density at the lumbar spine of pre- and postmenopausal womenBone1997213793839356730
  • AlbaghaOMMcGuiganFEReidDMRalstonSHEstrogen receptor α gene polymorphisms and bone mineral density: haplotype analysis in women from the United KingdomJ Bone Miner Res20011612813411149476
  • PouresmaeiliFRoohiATehraniMOsteoporosis and its association with estrogen receptor-alpha gene polymorphism in a population of iranian women referring to loghman hospitalInt J Endocrinol Metab20092009193199
  • van MeursJBSchuitSCWeelAEAssociation of 5′ estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture riskHum Mol Genet2003121745175412837697
  • NawataHTanakaSTanakaSAromatase in bone cell: association with osteoporosis in postmenopausal womenJ Steroid Biochem Mol Biol1995531651747626449
  • TranBNNguyenNDCenterJREismanJANguyenTVEnhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 geneCalcif Tissue Int20098537919789904
  • ChuMDe WetWBernardMRamirezFFine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcriptsJ Biol Chem1985260231523202857713
  • RossouwCVergeerWDu PlooySBernardMRamirezFDe WetWDNA sequences in the first intron of the human pro-alpha 1 (I) collagen gene enhance transcriptionJ Biol Chem198726215151151572822714
  • BrownMAHaughtonMAGrantSFGunnellASHendersonNKEismanJAGenetic control of bone density and turnover: role of the collagen 1α1, estrogen receptor, and vitamin D receptor genesJ Bone Miner Res20011675876411316004
  • KeenRSniederHMolloyHEvidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor β1 gene and hip bone mineral density: a study of female twinsRheumatology200140485411157141
  • YamadaYMiyauchiATakagiYTanakaMMizunoMHaradaAAssociation of the C–509→ T polymorphism, alone or in combination with the T869→ C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese womenJ Mol Med (Berl)20017914915611357939
  • RalstonSHAnalysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosisJ Bone Miner Res199498838908079663
  • MurrayRMcGuiganFGrantSReidDRalstonSPolymorphisms of the interleukin-6 gene are associated with bone mineral densityBone19972189929213013
  • TsukamotoKYoshidaHWatanabeSAssociation of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenoposal Japanese womenJ Hum Genet19994414815110319577
  • FerrariSGarneroPEmondSMontgomeryHHumphriesSGreenspanSA functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal womenArthritis Rheum20014419620111212160
  • GrayTMohanSLinkhartTBaylinkDEstradiol stimulates invitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106Biochem Biophys Res Commun19891584074122916989
  • KurlandESRosenCJCosmanFInsulin-Like Growth Factor-I in Men with Idiopathic Osteoporosis 1J Clin Endocrinol Metab199782279928059284699
  • KurlandESChanFKRosenCJBilezikianJPNormal growth hormone secretory reserve in men with idiopathic osteoporosis and reduced circulating levels of insulin-like growth factor-I 1J Clin Endocrinol Metab199883257625799661647
  • BragaVMottesMMirandolaSAssociation of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal womenCalcif Tissue Int20006736136611136533
  • MasiLBecheriniLColliEPolymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian womenBiochem Biophys Res Commun19982481901959675109
  • TabouletJFrenkianMFrendoJFeingoldNJullienneADe VernejoulMCalcitonin receptor olymorphism is associated with a decreased fracture risk in post-menopausal womenHum Mol Genet19987212921339817931
  • KeenRWoodford-RichensKLanchburyJSpectorTAllelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spineBone1998233673719763149
  • LennardAGormanPCarrierMCloning and chromosome mapping of the human interleukin-1 receptor antagonist geneCytokine1992483891385987
  • WongSYSLauEMCLiMChungTShamAWooJThe prevalence of Apo E4 genotype and its relationship to bone mineral density in Hong Kong ChineseJ Bone Miner Metab20052326126515838630
  • LingXAiminLXiheZXiaoshuCCummingsSRVery low rates of hip fracture in Beijing, People’s Republic of China: the Beijing Osteoporosis ProjectAm J Epidemiol19961449019078890668
  • FujiwaraNKMartiBGutzwillerFHip fracture mortality and morbidity in Switzerland and Japan: a cross-cultural comparisonSozialund Präventivmedizin199338814
  • BuehringBViswanathanRBinkleyNBusseWGlucocorticoid-induced osteoporosis: an update on effects and managementJ Allergy Clin Immunol20131321019103024176682
  • CanalisEMechanisms of glucocorticoid action in boneCurr Osteoporos Rep200539810216131429
  • Ramsey-GoldmanRMissed opportunities in physician management of glucocorticoid-induced osteoporosis?Arthritis Rheum2002463115312012483714
  • OhnakaKTanabeMKawateHNawataHTakayanagiRGlucocorticoid suppresses the canonical Wnt signal in cultured human osteoblastsBiochem Biophys Res Commun200532917718115721290
  • CanalisECentrellaMBurchWMcCarthyTLInsulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone culturesJ Clin Invest198983602910920
  • LundgrenERastadJThurfjellEÅkerströmGLjunghallSPopulation-based screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal womenSurgery19971212872949092129
  • WishartJHorowitzMNeedANordinBRelationship between forearm and vertebral mineral density in postmenopausal women with primary hyperparathyroidismArch Intern Med1990150132913312353865
  • VestergaardPMollerupCLFrøkjærVGChristiansenPBlichert-ToftMMosekildeLCohort study of risk of fracture before and after surgery for primary hyperparathyroidismBMJ200032159860210977834
  • SneddonWBMagyarCEWillickGELigand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragmentsEndocrinology20041452815282315016722
  • van AbelMHoenderopJGvan der KempAWFriedlaenderMMvan LeeuwenJPBindelsRJCoordinated control of renal Ca(2+) transport proteins by parathyroid hormone. TRPV5 & TRPV6Kidney Int20056841708172116164647
  • BrenzaHLKimmel-JehanCJehanFParathyroid hormone activation of the 25-hydroxyvitamin D3-1α-hydroxylase gene promoterProc Natl Acad Sci U S A199895138713919465024
  • JilkaRLMolecular and cellular mechanisms of the anabolic effect of intermittent PTHBone2007401434144617517365
  • KrollMHParathyroid hormone temporal effects on bone formation and resorptionBull Math Biol20006216318810824426
  • RazzaqueMSLanskeBThe emerging role of the fibroblast growth factor-23–klotho axis in renal regulation of phosphate homeostasisJ Endocrinol200719411017592015
  • GravalleseEBone destruction in arthritisAnn Rheum Dis200261ii84ii612379632
  • CooperCCouplandCMitchellMRheumatoid arthritis, corticosteroid therapy and hip fractureAnn Rheum Dis19955449527880122
  • Van StaaTGeusensPBijlsmaJLeufkensHCooperCClinical assessment of the long-term risk of fracture in patients with rheumatoid arthritisArthritis Rheumatism2006543104311217009229
  • NampeiAHashimotoJKoyanagiJCharacteristics of fracture and related factors in patients with rheumatoid arthritisMod Rheumatol20081817017618297237
  • AraiKHanyuTSugitaniHRisk factors for vertebral fracture in menopausal or postmenopausal Japanese women with rheumatoid arthritis: a cross-sectional and longitudinal studyJ Bone Miner Metab20062411812416502118
  • De NijsRJacobsJBijlsmaJPrevalence of vertebral deformities and symptomatic vertebral fractures in corticosteroid treated patients with rheumatoid arthritisRheumatology2001401375138311752508
  • PeelNMooreDBarringtonNBaxDEastellRRisk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritisAnn Rheum Dis1995548018067492217
  • GoldringSRGravalleseEMMechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implicationsArthritis Res199923311094416
  • ChuCQFieldMFeldmannMMainiRLocalization of tumor necrosis factor α in synovial tissues and at the cartilage–pannus junction in patients with rheumatoid arthritisArthritis Rheumatology19913411251132
  • ChuCQFieldMAllardSAbneyEFeldmannMMainiRDetection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repairRheumatology199231653661
  • DeleuranBChuCQFieldMLocalization of interleukin-1α, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritisRheumatology199231801809
  • RomasEMartinTCytokines in the pathogenesis of osteoporosisOsteoporos Int199774753
  • KotakeSUdagawaNTakahashiNIL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesisJ Clin Invest19991031345135210225978
  • ChabaudMDurandJMBuchsNHuman interleukin-17Arthritis Rheum19994296397010323452
  • FunkJLCordaroLAWeiHBenjaminJBYocumDESynovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritisJ Clin Invest19981011362
  • McClungMRole of RANKL inhibition in osteoporosisArthritis Res Ther20079Suppl 1S3
  • LacativaPGSFariasMLFDOsteoporosis and inflammationArq Bras Endocrinol Metabol201054212313220485900
  • MundyGROsteoporosis and inflammationNut Rev20076512 Pt 2S147S151
  • TeitelbaumSLOsteoclasts: what do they do and how do they do it?Am J Pathol2007170242743517255310
  • RouxCOsteoporosis in inflammatory joint diseasesOsteoporos Int2011222421433
  • DiarraDStolinaMPolzerKDickkopf-1 is a master regulator of joint remodelingNat Med200713215616317237793
  • WeitzmannMNPacificiRThe role of T lymphocytes in bone metabolismImmunol Rev200520815416816313347
  • van StaaTPLeufkensHGCooperCThe epidemiology of corticosteroid-induced osteoporosis: a meta-analysisOsteoporos Int2002131077778712378366
  • SchwartzAVDiabetes mellitus: does it affect bone?Calcif Tissue Int200373651551914517715
  • MokdadAHFordESBowmanBAPrevalence of obesity, diabetes, and obesity-related health risk factors, 2001JAMA20032891767912503980
  • BoyleJPThompsonTJGreggEWBarkerLEWilliamsonDFProjection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalencePopul Health Metr201082920969750
  • Al-HomoodIASheshahIMohammedAGAGasimGIThe prevalence and risk factors of osteoporosis among a Saudi female diabetic populationOpen Access Maced J Med Sci20175217718128507624
  • RaskaIJrBroulikPThe impact of diabetes mellitus on skeletal health: an established phenomenon with inestablished causesPrague Med Rep20051062137148
  • WongdeeKCharoenphandhuNOsteoporosis in diabetes mellitus: possible cellular and molecular mechanismsWorld J Diabetes201123414821537459
  • InzerilloAMEpsteinSOsteoporosis and diabetes mellitusRev Endocr Metab Disord2004526126815211098
  • Leidig-BrucknerGZieglerRDiabetes mellitus a risk for osteoporosis?Exp Clin Endocrinol Diabetes2001109S493S51411460594
  • TuominenJTImpivaaraOPuukkaPRönnemaaTBone mineral density in patients with type 1 and type 2 diabetesDiabetes Care19992271196120010388989
  • IsidroMLRuanoBBone disease in diabetesCurr Diabetes Rev20106314415520380629
  • SchwartzAVSellmeyerDEEnsrudKEStudy of Osteoporotic Features Research GroupOlder women with diabetes have an increased risk of fracture: a prospective studyJ Clin Endocrinol Metab2001861323811231974
  • NicodemusKKFolsomARIowa Women’s Health StudyType 1 and type 2 diabetes and incident hip fractures in postmenopausal womenDiabetes Care20012471192119711423501
  • JanghorbaniMVan DamRMWillettWCHuFBSystematic Review of Type 1 and Type 2 Diabetes Mellitus and Risk of FractureOxfordOxford Univ Press2007
  • FarmerMEWhiteLRBrodyJABaileyKRRace and sex differences in hip fracture incidenceAm J Public Health19847412137413806507690
  • CummingsSRNevittMCBrownerWSRisk factors for hip fracture in white womenN Engl J Med1995332127677747862179
  • KumedaYOsteoporosis in diabetesClin Calcium2008185589599 Japanese18445876
  • YangJZhangXWangWLiuJInsulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cellsCell Biochem Funct201028433434120517899
  • GolubEEBoesze-BattagliaKThe role of alkaline phosphatase in mineralizationCurr Opin Orthop200718444448
  • WangWZhangXZhengJYangJHigh glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathwayMol Cell Biochem20103381–211512219949837
  • BotolinSFaugereMCMallucheHOrthMMeyerRMcCabeLRIncreased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic miceEndocrinology200514683622363115905321
  • Lecka-CzernikBMoermanEJGrantDFLehmannJMManolagasSCJilkaRLDivergent effects of selective peroxisome proliferator-activated receptor-γ2 ligands on adipocyte versus osteoblast differentiationEndocrinology200214362376238412021203
  • DiascroDDJrVogelRLJohnsonTEHigh fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cellsJ Bone Miner Res1998131961069443795
  • ElefteriouFAhnJDTakedaSLeptin regulation of bone resorption by the sympathetic nervous system and CARTNature2005434703251452015724149
  • ShiYYadavVKSudaNDissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivoProc Natl Acad Sci U S A200810551205292053319074282
  • HieMIitsukaNOtsukaTTsukamotoIInsulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activationInt J Mol Med201128345546221567076
  • LinCLWangJYKoJYHuangYTKuoYHWangFSDick-kopf-1 promotes hyperglycemia–induced accumulation of mesangial matrix and renal dysfunctionJ Am Soc Nephrol201021112413520019166
  • García-MartínARozas-MorenoPReyes-GarcíaRCirculating levels of sclerostin are increased in patients with type 2 diabetes mellitusJ Clin Endocrinol Metab201297123424122031520
  • KaneRStevensonLGodsonCStittAO’BrienCGremlin gene expression in bovine retinal pericytes exposed to elevated glucoseBr J Ophthalmol200589121638164216299147
  • AlyasinSMomenTKashefSAlipourAAminRThe relationship between serum 25 hydroxy vitamin d levels and asthma in childrenAllergy Asthma Immunol Res20113425125521966605
  • ModestiABertolozziIGamberiTHyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stressDiabetes200554239440115677497
  • KimHJKimSHYunJMFisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanismsEvid Based Complement Alternat Med2012201263946923320034
  • GonzalezYHerreraMTSoldevilaGHigh glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytesBMC Immunol2012131922500980
  • BinkleyNVitamin D and osteoporosis-related fractureArch Biochem Biophys2012523111512222349359
  • PalomerXGonzález-ClementeJBlanco-VacaFMauricioDRole of vitamin D in the pathogenesis of type 2 diabetes mellitusDiabetes Obes Metab200810318519718269634
  • MenegazzoLAlbieroMAvogaroAFadiniGPEndothelial progenitor cells in diabetes mellitusBiofactors201238319420222488933
  • HamannCKirschnerSGüntherKPHofbauerLCBone, sweet bone-osteoporotic fractures in diabetes mellitusNat Rev Endocrinol20128529730522249517
  • SugimotoKYasujimaMYagihashiSRole of advanced glycation end products in diabetic neuropathyCurr Pharm Des2008141095396118473845
  • JackMWrightDRole of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathyTransl Res2012159535536522500508
  • CatalanoAMorabitoNDi ViesteGPhalangeal quantitative ultrasound and metabolic control in pre-menopausal women with type 1 diabetes mellitusJ Endocrinol Invest201336534735123027769
  • NeumannTLodesSKastnerBTrabecular bone score in type 1 diabetes-a cross-sectional studyOsteoporos Int201627112713326187124
  • WalshJSVilacaTObesity, type 2 diabetes and bone in adultsCalcif Tissue Int2017100552853528280846
  • MoayeriAMohamadpourMMousaviSFShirzadpourEMohamadpourSAmraeiMFracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysisTher Clin Risk Manag20171345546828442913
  • Tysiewicz-DudekMPietraszkiewiczFDrozdzowskaBAlzheimer’s disease and osteoporosis: common risk factors or one condition predisposing to the other?Ortop Traumatol Rehabil2007104315323 Polish
  • WellerISchatzkerJHip fractures and Alzheimer’s disease in elderly institutionalized CanadiansAnn Epidemiol200414531932415177270
  • BakerNLCookMNArrighiHMBullockRHip fracture risk and subsequent mortality among Alzheimer’s disease patients in the United Kingdom, 1988–2007Age Ageing2011401495421087990
  • HaasumYFastbomJFratiglioniLJohnellKUndertreatment of osteoporosis in persons with dementia? A population-based studyOsteoporos Int20122331061106821499775
  • ButterfieldDAAmyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer’s disease brain. A reviewFree Radic Res200236121307131312607822
  • BehlCDavisJLesleyRSchubertDHydrogen peroxide mediates amyloid β protein toxicityCell19947768178278004671
  • JulesJZhangPAshleyJWMolecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesisJ Biol Chem201228719157281573822416138
  • BiverEHardouinPCaverzasioJThe “bone morphogenic proteins” pathways in bone and joint diseases: translational perspectives from physiopathology to therapeutic targetsCytokine Growth Factor Rev2013241698122749766
  • KimMSYangYMSonARANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesisJ Biol Chem2010285106913692120048168
  • ParkHSLeeSHParkDSequential activation of phosphati-dylinositol 3-kinase, βPix, Rac1, and Nox1 in growth factor-induced production of H2O2Mol Cell Biol200424104384439415121857
  • BodmerJLSchneiderPTschoppJThe molecular architecture of the TNF superfamilyTrends Biochem Sci2002271192611796220
  • LuckhausCMahabadiBGrass-KapankeBBlood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer’s diseaseJ Neural Transm (Vienna)2009116790591119468818
  • ColemanREClinical features of metastatic bone disease and risk of skeletal morbidityClin Cancer Res20061220 Pt 26243s6249s17062708
  • MundyGRMetastasis to bone: causes, consequences and therapeutic opportunitiesNat Rev Cancer20022858459312154351
  • ZhangJDaiJQiYOsteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the boneJ Clin Invest2001107101235124411375413
  • BoydeAMaconnachieEReidSADellingGMundyGScanning electron microscopy in bone pathology: review of methods, potential and applicationsScan Electron Microsc1986Pt 4153715543544196
  • RizzoliRBodyJJBrandiMLInternational Osteoporosis Foundation Committee of Scientific Advisors Working Group on Cancer-Induced Bone DiseaseCancer-associated bone diseaseOsteoporos Int201324122929295324146095
  • LauYKLeeEPriorHJLixLMMetgeCJLeslieWDFracture risk in androgen deprivation therapy: a Canadian population based analysisCan J Urol20091664908491420003666
  • BondySJIscoeNARothwellDMTrends in hormonal management of prostate cancer: a population-based study in OntarioMed Care200139438439611329525
  • Falahati-NiniARiggsBLAtkinsonEJO’FallonWMEastellRKhoslaSRelative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly menJ Clin Invest2000106121553156011120762
  • DickmanPWAdolfssonJÅstrÖmKSteineckGHip fractures in men with prostate cancer treated with orchiectomyJ Urol20041726 Pt 12208221215538233
  • HandforthCD’OronzoSColemanRBrownJCancer treatment and bone healthCalcified Tissue International2018114
  • ReidIRIbbertsonHKCalcium supplements in the prevention of steroid-induced osteoporosisAm J Clin Nutr19864422872903728366
  • LaneNEKelmanAA review of anabolic therapies for osteoporosisArthritis Res Ther20035521422212932280
  • MosekildeLPrimary hyperparathyroidism and the skeletonClin Endocrinol (Oxf)200869111918167138
  • CremersSCPillaiGPapapoulosSEPharmacokinetics/pharmaco-dynamics of bisphosphonates: use for optimisation of intermittent therapy for osteoporosisClin Pharmacokinet200544655157015932344
  • KennelKADrakeMTAdverse effects of bisphosphonates: implications for osteoporosis managementMayo Clin Proc200984763263819567717
  • CauleyJASeeleyDGEnsrudKEttingerBBlackDCummingsSREstrogen replacement therapy and fractures in older women. Study of Osteoporotic Fractures Research GroupAnn Intern Med199512219167985914
  • BerningBKuijkCVKuiperJWBenninkHJKicovicPMFauserBCEffects of two doses of tibolone on trabecular and cortical bone loss in early postmenopausal women: a two-year randomized, placebo-controlled studyBone19961943953998894146
  • DelmasPDEnsrudKEAdachiJDMulitple Outcomes of Raloxifene Evaluation InvestigatorsEfficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trialJ Clin Endocrinol Metab20028783609361712161484
  • KharodeYBodinePVMillerCPLyttleCRKommBSThe pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis preventionEndocrinology2008149126084609118703623
  • BoneHGMcClungMRRouxCOdanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone densityJ Bone Miner Res201025593794719874198
  • BabatundeOTMarquezSTaylorAOsteoporosis knowledge and health beliefs among men in midlife yearsJ Nutr Educ Behav2017499759.e1763.e128655501
  • HardingATBeckBRExercise, osteoporosis, and bone geometrySports2017529
  • ZhuKPrinceRLLifestyle and osteoporosisCurr Osteoporos Rep2015131525925416958
  • YangPChenCChiouHYLiYLHsuGSWThe exercise intervention may influence the dietary intake and reduce the risk of osteoporosis and sarcopenia in menopausal womenFASEB J201731967969
  • ManolagasSCBirth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis 1Endocr Rev200021211513710782361
  • Dawson-HughesBGoldDRodbardHPhysician’s Guide to Prevention and Treatment of OsteoporosisWashington, DC, USANational Osteoporosis Foundation2003
  • KanisJAOdenAJohanssonHBorgströmFStrömOMcCloskeyEFRAX® and its applications to clinical practiceBone200944573474319195497
  • VuoriIMDose-response of physical activity and low back pain, osteoarthritis, and osteoporosisMed Sci Sports Exerc2001336 SupplS551S58611427782
  • DrinkwaterBLDoes physical activity play a role in preventing osteoporosis?Res Q Exerc Sport1994651972067973068
  • AldahrMHSBone mineral status response to aerobic versus resistance exercise training in postmenopausal womenWorld Appl Sci J2012166806813
  • ShackelfordLCLeBlancADDriscollTBResistance exercise as a countermeasure to disuse-induced bone lossJ Appl Physiol (1985)200497111912915220316
  • HernandezCJBeaupreGSCarterDRA theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosisOsteoporos Int2003141084384712904837
  • BonjourJPChevalleyTRizzoliRFerrariSGene-environment interactions in the skeletal response to nutrition and exercise during growth. Optimizing Bone Mass and Strength. Karger PublishersMed Sport Sci200751648017505120
  • WattsNBLewieckiEMMillerPDBaimSNational osteoporosis foundation 2008 clinician’s guide to prevention and treatment of osteoporosis and the world health organization Fracture Risk Assessment Tool (FRAX): what they mean to the bone densitometrist and bone technologistJ Clin Densitom200811447347718562228
  • CouncilNrDRI (Dietary Reference Intakes) for Calcium, Phosphorus, Magnesium, Vitamin D, and FluorideWashington, DC, USANational Academy Press1997
  • Dawson-HughesBHarrisSSKrallEADallalGEEffect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or olderN Engl J Med1997337106706769278463
  • KendlerDLMarinFZerbiniCAEffects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trialThe Lancet201839110117230240
  • KanisJAOdénAMcCloskeyEVJohanssonHWahlDACooperCA systematic review of hip fracture incidence and probability of fracture worldwideOsteoporosis International20122392239225622419370
  • EvattMLDeLongMRKhazaiNRosenATricheSTangprichaVPrevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer diseaseArchives of Neurology200865101348135218852350
  • DurrinLKHaileRWInglesSACoetzeeGAVitamin D receptor 3′-untranslated region polymorphisms: lack of effect on mRNA stabilityBiochimica et Biophysica Acta (BBA)-Molecular Basis of Disease19991453331132010101249
  • RemesTVäisänenSBMahonenABone mineral density, body height, and vitamin D receptor gene polymorphism in middle-aged menAnnals of Medicine200537538339216179274
  • LambrinoudakiIKaparosGArmeniEBsmI vitamin D receptor’s polymorphism and bone mineral density in men and premeno-pausal women on long-term antiepileptic therapyEuropean Journal of Neurology2011181939820500803
  • WangLMaJMansonJEBuringJEGazianoJMSessoHDA prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in menEuropean Journal of Nutrition20135271771177923262750
  • IoannidisJPRalstonSHBennettSTDifferential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomesJAMA2004292172105211415523071
  • YamadaYAndoFNiinoNOhtaSShimokataHAssociation of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese womenJournal of Molecular Medicine200280745246012110951
  • TangLChengG-LXuZ-HAssociation between estrogen receptor α gene (ESR1) PvuII (C/T) and XbaI (A/G) polymorphisms and hip fracture risk: evidence from a meta-analysisPloS One2013812e8280624482673
  • OgawaSFujitaMIshiiYImpaired estrogen sensitivity in bone by inhibiting both estrogen receptor α and β pathwaysJournal of Biological Chemistry200027528213722137910806217
  • LauHHoALukKKungAEstrogen receptor β gene polymorphisms are associated with higher bone mineral density in premeno-pausal, but not postmenopausal southern Chinese womenBone200231227628112151079
  • ScarianoJSimplicioSMontoyaGGarryPBaumgartnerREstrogen receptor β dinucleotide (CA) repeat polymorphism is significantly associated with bone mineral density in postmenopausal womenCalcified Tissue International200474650150815354857
  • KungAWLaiBMNgMYChanVShamPCT-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fracturesBone20063951097110616777502
  • MiyaoMHosoiTEmiMAssociation of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locusJournal of Human Genetics200045634635011185743
  • MaganaJGomezRCisnerosBAssociation of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican womenClinical Genetics200670540240817026622
  • TuralSKaraNAlayliGTomakLAssociation between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal womenGene2013515116717223137636
  • HosoiTMiyaoMInoueSAssociation study of parathyroid hormone gene polymorphism and bone mineral density in Japanese postmenopausal womenCalcified Tissue International199964320520810024376
  • MinagawaMYasudaTWatanabeTAssociation between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activityThe Journal of Clinical Endocrinology & Metabolism20028741791179611932319
  • NapoliNRastelliAMaCGenetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER (+) breast cancerBone201355230931423643682
  • ZmudaJMCauleyJAKullerLHFerrellREA common promoter variant in the cytochrome P450c17α (CYP17) gene is associated with bioavailable testosterone levels and bone size in menJournal of Bone and Mineral Research200116591191711341336
  • SharpLCardyAHCottonSCLittleJCYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE reviewAmerican Journal of Epidemiology2004160872974015466495
  • HuizengaNAde LangePKoperJWHuman adrenocorticotro-pin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locusThe Journal of Clinical Endocrinology & Metabolism19988339179219506748
  • TsukamotoKOrimoHHosoiTAssociation of bone mineral density with polymorphism of the human calcium-sensing receptor locusCalcified Tissue International200066318118310666491
  • LangdahlBLStenkjaerLCarstensMToftengCEriksenEA CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fracturesCalcified Tissue International200373323724314667136
  • LangdahlBLCarstensMStenkjærLEriksenEFPolymorphisms in the transforming growth factor beta 1 gene and osteoporosisBone200332329731012667558
  • RivadeneiraFHouwing-DuistermaatJJVaessenNAssociation between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotter-dam StudyThe Journal of Clinical Endocrinology & Metabolism20038883878388412915683
  • ArkoBPreželjJKocijančičAKomelRMarcJAssociation of the osteoprotegerin gene polymorphisms with bone mineral density in postmenopausal womenMaturitas200551327027915978970
  • Garcia-UnzuetaMRianchoJZarrabeitiaMAssociation of the 163A/G and 1181G/C osteoprotegerin polymorphism with bone mineral densityHormone and Metabolic Research2008400321922418348083
  • JuradoSNoguésXAguedaLPolymorphisms and haplo-types across the osteoprotegerin gene associated with bone mineral density and osteoporotic fracturesOsteoporosis International2010;21228729619436932
  • MencejSAlbaghaOMPreželjJKocjanTMarcJTumour necrosis factor superfamily member 11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in postmenopausal women with osteoporosisJournal of Molecular Endocrinology200840627327918502820
  • HoshinoSHosoiTShirakiMOrimoHOuchiYInoueSAssociation of tumor necrosis factor receptor 1 gene polymorphism with bone mineral densityGeriatrics & Gerontology International200332101105
  • GrantSFReidDMBlakeGHerdRFogelmanIRalstonSHReduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 geneNature Genetics19961422038841196
  • LauEChoyDLiMWooJChungTShamAThe relationship between COLI A1 polymorphisms (Sp 1) and COLI A2 polymorphisms (Eco R1 and Puv II) with bone mineral density in Chinese men and womenCalcified Tissue International200475213313715085313
  • ChenHYTsaiHDChenWCWuJYTsaiFJTsaiCHRelation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in TaiwanJournal of Clinical Laboratory Analysis200115525125511574953
  • McGuiganFKumarJIvaskaKKObrantKJGerdhemPÅkessonKOsteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identificationJournal of Bone and Mineral Research20102561392139920200947
  • ZebboudjAFImuraMBoströmKMatrix GLA protein, a regulatory protein for bone morphogenetic protein-2Journal of Biological Chemistry200227764388439411741887
  • EichnerJEFriedrichCACauleyJAAlpha 2-HS glycoprotein phenotypes and quantitative hormone and bone measures in postmenopausal womenCalcified Tissue International19904763453491705475
  • JohnstonJMCauleyJAGanguliMAPOE 4 and hip fracture risk in a community-based study of older adultsJournal of the American Geriatrics Society199947111342134510573444
  • CauleyJAZmudaJMYaffeKApolipoprotein E polymorphism: A new genetic marker of hip fracture risk–The Study of Osteoporotic FracturesJ Bone Miner Res19991471175118110404018
  • VilladsenMMBüngerMHCarstensMStenkjærLLangdahlBLMethylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMDOsteoporosis International200516441141615300362
  • UranoTInoueSGenetics of osteoporosisBiochemical and Biophysical Research Communications2014452228729325139232
  • DouroudisKTarassiKAthanassiadesTHLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek populationTissue Antigens200769659259617498269
  • AltshulerDHirschhornJNKlannemarkMThe common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetesNature Genetics20002617610973253
  • AlbaghaOMcGuiganFReidDRalstonSNovel polymorphism in the human Fos related antigen-1gene is associated with bone mineral density in women from the UKPaper presented at: Journal of Bone and Mineral Research2002
  • VaughanTPascoJAKotowiczMANicholsonGCMorrisonNAAlleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fractureJournal of Bone and Mineral Research20021781527153412162506
  • DoeckeJDDayCJStephensASAssociation of functionally different RUNX2 P2 promoter alleles with BMDJournal of Bone and Mineral Research200621226527316418782
  • KawanoKIOgataNChianoMKlotho gene polymorphisms associated with bone density of aged postmenopausal womenJournal of Bone and Mineral Research200217101744175112369777
  • OgataNShirakiMHosoiTKoshizukaYNakamuraKKawaguchiHA polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal womenJournal of Bone and Mineral Metabolism200119529630111498731
  • BabijPZhaoWSmallCHigh bone mass in mice expressing a mutant LRP5 geneJournal of Bone and Mineral Research200318696097412817748
  • AiMHolmenSLVan HulWWilliamsBOWarmanMLReduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signalingMolecular and Cellular Biology200525124946495515923613
  • GiraudeauFSMcginnisREGrayICCharacterization of common genetic variants in cathepsin K and testing for association with bone mineral density in a large cohort of perimenopausal women from ScotlandJournal of Bone and Mineral Research2004191314114753734
  • BabuLRWilsonSDickIIslamFDevineAPrinceRBone mass effects of a BMP4 gene polymorphism in postmenopausal womenBone200536355556115777683
  • PetterssonUAlbaghaOMMiroloMPolymorphisms of the CLCN7 gene are associated with BMD in womenJournal of Bone and Mineral Research200520111960196716234969
  • KornakUOstertagABrangerSBenichouOde VernejoulM-CPolymorphisms in the CLCN7 gene modulate bone density in postmenopausal women and in patients with autosomal dominant osteopetrosis type IIThe Journal of Clinical Endocrinology & Metabolism2006913995100016368748
  • LeeS-HRhoJJeongDv-ATPase V 0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formationNature Medicine200612121403
  • MariniFFalchettiASilvestriSModulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosisCurrent Medical Research and Opinion20082492609261518687167
  • GartlandASkarrattKKHockingLJPolymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal womenEuropean Journal of Human Genetics201220555922234152