291
Views
38
CrossRef citations to date
0
Altmetric
Case Report

A case of chronic eosinophilic pneumonia in a patient treated with dupilumab

, , , , , , & show all
Pages 869-875 | Published online: 10 Jul 2019

Figures & data

Figure 1 Chest x-ray: bilateral pulmonary opacities.

Figure 1 Chest x-ray: bilateral pulmonary opacities.

Figure 2 Chest high-resolution CT scan pre-post oral corticosteroids (OCS) treatment: (A) bilaterally, areas of parenchymal thickening with plane bronchograms, confluent, located in the upper lobes bilaterally, and peripherally, in the postero-lateral mantle area of the supero-lateral segment of the upper lobe. (B) Areas of parenchymal thickening with plane bronchograms on the apical of the inferior right lobe. (C, D) Resolution of parenchymal thickening after OCS therapy.

Figure 2 Chest high-resolution CT scan pre-post oral corticosteroids (OCS) treatment: (A) bilaterally, areas of parenchymal thickening with plane bronchograms, confluent, located in the upper lobes bilaterally, and peripherally, in the postero-lateral mantle area of the supero-lateral segment of the upper lobe. (B) Areas of parenchymal thickening with plane bronchograms on the apical of the inferior right lobe. (C, D) Resolution of parenchymal thickening after OCS therapy.

Figure 3 Biopsies: (A) transbronchial biopsies sampled several good-quality lung fragments (hematoxylin-eosin, 20× magnification). (B) A subacute lung injury was present, consisting of foci of organizing pneumonia with pneumocyte hyperplasia and several interstitial and intra-alveolar eosinophils (hematoxylin-eosin, 400× magnification). (C) In some areas, intra-alveolar foamy macrophages were intermingled with eosinophils (hematoxylin-eosin, 400× magnification). There were no extravascular granulomas, small and medium-sized vessels vasculitis.

Figure 3 Biopsies: (A) transbronchial biopsies sampled several good-quality lung fragments (hematoxylin-eosin, 20× magnification). (B) A subacute lung injury was present, consisting of foci of organizing pneumonia with pneumocyte hyperplasia and several interstitial and intra-alveolar eosinophils (hematoxylin-eosin, 400× magnification). (C) In some areas, intra-alveolar foamy macrophages were intermingled with eosinophils (hematoxylin-eosin, 400× magnification). There were no extravascular granulomas, small and medium-sized vessels vasculitis.

Figure 4 Case report timeline.

Figure 4 Case report timeline.