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Therapeutics and Clinical Risk Management Volume 15, 2019 - Issue
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Case Report

A case of chronic eosinophilic pneumonia in a patient treated with dupilumab

Francesco Menzella1 Department of Medical Specialties, Pneumology Unit, Azienda USL di Reggio Emilia, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, ItalyCorrespondence[email protected]
,
Gloria Montanari1 Department of Medical Specialties, Pneumology Unit, Azienda USL di Reggio Emilia, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
,
Giulia Patricelli2 Pneumology Unit, A. Perrino Hospital, Brindisi, Italy
,
Alberto Cavazza3 Department of Pathology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
,
Carla Galeone1 Department of Medical Specialties, Pneumology Unit, Azienda USL di Reggio Emilia, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
,
Patrizia Ruggiero1 Department of Medical Specialties, Pneumology Unit, Azienda USL di Reggio Emilia, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
,
Diego Bagnasco4 Allergy & Respiratory Diseases, University of Genoa, Genoa, Italy
&
Nicola Facciolongo1 Department of Medical Specialties, Pneumology Unit, Azienda USL di Reggio Emilia, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
 show all
Pages 869-875 | Published online: 10 Jul 2019

References

  • Loza MJ, Djukanovic R, Chung KF, et al. ADEPT (Airways disease endotyping for personalized therapeutics) and U-BIOPRED (Unbiased biomarkers for the prediction of respiratory disease outcome consortium) investigators. Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study. Respir Res. 2016;17(1):165.27978840
  • Shaw DE, Sousa AR, Fowler SJ, et al. Clinical and inflammatory characteristic of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308–1321. doi:10.1183/13993003.00779-201526357963
  • Lefebvre P, Duh MS, Lafeuille MH, et al. Acute and chronic systemic corticosteroid-related complications in patients with severe asthma. J Allergy Clin Immunol. 2015;136(6):1488–1495. doi:10.1016/j.jaci.2015.07.04626414880
  • Rabe KF, Nair P, Brusselle G, et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. N Engl J Med. 2018;378(26):2475–2485. doi:10.1056/NEJMoa180409329782224
  • Adachi M, Kozawa M, Yoshisue H, et al. Real-world safety and efficacy of omalizumab in patients with severe allergic asthma: a long-term post-marketing study in Japan. Respir Med. 2018;141:56–63. doi:10.1016/j.rmed.2018.06.02130053973
  • Barranco P, Phillips-Angles E, Dominguez-Ortega J, Quirce S. Dupilumab in the management of moderate-to-severe asthma: the data so far. Ther Clin Risk Manag. 2017;13:1139–1149. doi:10.2147/TCRM.S12596428979129
  • Wenzel S, Ford L, Pearlman D, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013;368(26):2455–2466. doi:10.1056/NEJMoa130404823688323
  • Weissler JC. Eosinophilic lung disease. Am J Med Sci. 2017;354(4):339–349. doi:10.1016/j.amjms.2017.03.02029078837
  • Bartal C, Sagy I, Barski L. Drug-induced eosinophilic pneumonia: a review of 196 case reports. Medicine (Baltimore). 2018;97(4):e9688. doi:10.1097/MD.000000000000968829369189
  • Price M, Gilman MD, Carter BW, Sabloff BS, Truong MT, Wu CC. Imaging of eosinophilic lung diseases. Radiol Clin North Am. 2016;54(6):1151–1164. doi:10.1016/j.rcl.2016.05.00827719981
  • Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa180409229782217
  • Punia N, Smith S, Thomson JV, Irshad A, Nair P, Sehmi R. Interleukin-4 and interleukin-13 prime migrational responses of haemopoietic progenitor cells to stromal cell-derived factor-1α. Clin Exp Allergy. 2012;42(2):255–264. doi:10.1111/j.1365-2222.2011.03889.x22092872
  • Johnston LK, Hsu CL, Krier-Burris RA, et al. IL-33 precedes IL-5 in regulating eosinophil commitment and is required for eosinophil homeostasis. J Immunol. 2016;197:3445–3453. doi:10.4049/jimmunol.160061127683753
  • Allakhverdi Z, Comeau MR, Smith DE, et al. CD34þ hemopoietic progenitor cells are potent effectors of allergic inflammation. J Allergy Clin Immunol. 2009;123:472–478. doi:10.1016/j.jaci.2008.10.02219064280
  • Smith SG, Gugilla A, Mukherjee M, et al. Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma. J Allergy Clin Immunol. 2015;135:1594–1602. doi:10.1016/j.jaci.2014.12.191825656998
  • Phillips C, Coward WR, Pritchard DI, Hewitt CR. Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites. J Leukoc Biol. 2003;73:165–171. doi:10.1189/jlb.070235612525574
  • Wu D, Molofsky AB, Liang HE, et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011;332:243–247. doi:10.1126/science.332.6026.173-c21436399
  • Shinkai K, Mohrs M, Locksley RM. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002;420:825–829. doi:10.1038/nature0113112490951
  • Qiu Y, Nguyen KD, Odegaard JI, et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014;157:1292–1308. doi:10.1016/j.cell.2014.03.04024906148
  • Webb DC, McKenzie AN, Koskinen AM, Yang M, Mattes J, Foster PS. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J Immunol. 2000;165(1):108–113. doi:10.4049/jimmunol.165.1.10810861042
  • Gour N, Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015;75(1):68–78. doi:10.1016/j.cyto.2015.05.01426070934
  • Gandhi NA, Pirozzi G, Graham NMH. Commonality of the IL-4/IL-13 pathway in atopic diseases. Expert Rev Clin Immunol. 2017;13(5):425–437. doi:10.1080/1744666X.2017.129844328277826

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