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Therapeutics and Clinical Risk Management Volume 20, 2024 - Issue
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CLINICAL TRIAL REPORT

The Efficacy and Safety of Diazepam for Intraoperative Blood Pressure Stabilization in Hypertensive Patients Undergoing Vitrectomy Under Nerve Block Anesthesia: A Prospective, Single-Center, Double-Blind, Randomized, Controlled Trial

Tianwei Qian1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-7359-911XView further author information
ORCID Icon,
Qiaoyun Gong1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Yiyang Shu1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Hangqi Shen1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Xia Wu1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Weijun Wang1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Zhihua Zhang1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Hui Cao1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Xun Xu1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 National Clinical Research Center for Eye Diseases, Shanghai, People’s Republic of China;3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, People’s Republic of China;4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of China;5 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai, People’s Republic of ChinaView further author information
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Pages 9-18 | Received 11 Oct 2023, Accepted 18 Dec 2023, Published online: 12 Jan 2024

Figures & data

Table 1 Baseline and Preoperative Clinical Characteristics of All Patients

Table 2 Primary Outcome: Comparison of Effective Rate of Intraoperative SBP Control Between Diazepam and Placebo Group

Figure 1 Kaplan–Meier survival plot of diazepam group and placebo group according to effective BP control. Patients in the diazepam group (dashed line) had significantly higher effective BP rates during the surgery than patients in the placebo group (solid line) (P = 0.0146).

Figure 1 Kaplan–Meier survival plot of diazepam group and placebo group according to effective BP control. Patients in the diazepam group (dashed line) had significantly higher effective BP rates during the surgery than patients in the placebo group (solid line) (P = 0.0146).

Table 3 Secondary Outcomes: Comparison of Diazepam and Placebo Group

Table 4 Comparison of Clinical Characteristics Between the Effective BP Control Group and Ineffective BP Control Group

Table 5 Logistic Regression Analysis of Risk Factors for Ineffective BP Control

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