Ascorbic Acid vs Calcitriol in Influencing Monocyte Chemoattractant Protein-1, Nitric Oxide, Superoxide Dismutase, as Markers of Endothelial Dysfunction: In Vivo Study in Atherosclerosis Rat Model

Figures & data

Table 1 Effect on MCP-1, NO, and SOD Levels in All Group

Serum	Group	n	Mean (SD)	P value
MCP	N	6	346 (52.8)	0.006
	DL	6	413 (77.1)
	DLC	6	284 (38.5)
	N	6	346 (52.8)	0.007
	DL	6	413 (77.1)
	DLD	6	295 (13.6)
NO	N	6	55.7 (16.3)	0.001
	DL	6	37.6 (10.2)
	DLC	6	70.9 (9.1)
	N	6	55.7 (16.3)	0.02
	DL	6	37.6 (10.2)
	DLD	6	83.7 (41.1)
SOD	N	6	432 (9.7)	0.000
	DL	6	195 (9.4)
	DLC	6	91.6 (10.1)
	N	6	43.2 (9.7)	0.000
	DL	6	19.5 (9.4)
	DLD	6	115.6 (5.2)

Table 2 Post Hoc Analysis of MCP-1, NO, and SOD Levels in DLC and DLD

Serum	Group	Mean Difference	CI 95%		P value
			Max	Min
MCP	DL vs DLC	128	37	218	0.005
	DL vs DLD	117	32	202	0.006
NO	DL vs DLC	33.2	14.1	52.4	0.001
	DL vs DLD	46.1	5.3	86.8	0.02
SOD	DL vs DLC	72.0	56.8	87.2	0.000
	DL vs DLD	96.0	82.9	109.1	0.000

Table 3 Comparison of Ascorbic Acid vs Calcitriol in Decreasing MCP-1, and Increasing NO and SOD

Serum	Group	Mean (SD)	P value
MCP-1	DLC	284 (38)	0.544
	DLD	295 (13)
NO	DLC	70.9 (9.1)	0.472
	DLD	83.7 (41.1)
SOD	DLC	91.6 (10.1)	0.000
	DLD	115.6 (5.2)