Figures & data
Both reduce microalbuminuria and rate of nephropathy independently of their antihypertensive effect.
ACEi preferred over ARB (indirect evidence for cardiovascular outcomes; SCOPE,Citation70 VALUECitation71 and TRANSCENDCitation72).
Recommend against concomitant use of ARB with ACEi (ONTARGETCitation75 and VALIANTCitation76).
Dihydropyridine CCB favored over diuretic (ACCOMPLISHCitation82 and GUARDCitation83) or in the presence of electrolyte anomalies.
Diuretic preferred in heart failure or edematous conditions.
Loop diuretic recommended if GFR ≤ 30 mL/min due to marked state of fluid overload.
If needed, CCB and diuretic can be combined.