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Epigenomics Volume 8, 2016 - Issue 6
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Review

The Promise of Epigenomic Therapeutics in Pancreatic Cancer

Gwen A Lomberk1 Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USACorrespondence[email protected]
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,
Juan Iovanna2 Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université & Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, FranceView further author information
&
Raul Urrutia1 Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USAView further author information
Pages 831-842 | Received 21 Dec 2015, Accepted 07 Mar 2016, Published online: 23 Jun 2016

Figures & data

Figure 1. DNA methyltransferases function to preserve patterns of DNA methylation.

DNMT1 methylates the correct cytosine in the newly synthesized DNA strand, whereas during embryogenesis, de novo DNA methylation is mediated by DNMT3A and DNMT3B.

Me: Methylation.

Figure 1. DNA methyltransferases function to preserve patterns of DNA methylation.DNMT1 methylates the correct cytosine in the newly synthesized DNA strand, whereas during embryogenesis, de novo DNA methylation is mediated by DNMT3A and DNMT3B.Me: Methylation.

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