Open Label Trial of the Tolerability and Efficacy of Zonisamide in the Treatment of Alcohol Dependence

Figures & data

TABLE 1.  Demographic and clinical characteristics of alcohol dependent subjects admitted into the zonisamide trial. Mean (± SE) values are presented where appropriate.

	Zonisamide (n = 16)
Age	50.7 ± 1.6
Sex
Male	13
Female	3
Percent Caucasian	100
Education (yrs)	16.0 ± 1.1
Pre-screening drinks/day	10.4 ± 1.5
ADS	14.1 ± 1.5
AUDIT	23.6 ± 1.2
MAST	7.7 ±.9

TABLE 2.  Mean (± SE) and (range) of values obtained for the effects of zonisamide on the phonetic and semantic portions of the Controlled Word Association Test (COWAT) and on the Symbol Digit Modalities Test (DSMT).

Treatment Week	Week 0	Week 4	Week 12
COWAT semantic	21.1 (± 1.4) (11–32)	21.5 (± 1.4) (14–32)	21.9 (± 2.0) (16–29)
COWAT phonetic	45. 3 (± 3.9) (21–65)	37.0 (± 3.9) (24–67)	38.9 (± 3.9) (22–58)
DMST	53.3 (± 3.0) (38–65)	48.9 (± 3.0) (33–64)	51.8 (± 4.6) (44–79)