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Research Articles

Magnetic targeting and ultrasound mediated drug delivery: Benefits, limitations and combination

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Pages 362-373 | Received 01 Dec 2011, Accepted 17 Feb 2012, Published online: 23 May 2012

Figures & data

Figure 1. Theoretical structure of a magnetic microbubble based upon the formulation by Stride et al. The gas core is surrounded by a ferrofluid and stabilized by an outer coating of L-α-phosphatidylcholine. The average size is about 2 µm.

Figure 1. Theoretical structure of a magnetic microbubble based upon the formulation by Stride et al. The gas core is surrounded by a ferrofluid and stabilized by an outer coating of L-α-phosphatidylcholine. The average size is about 2 µm.

Figure 2. Bioluminescence imaging data for transfection enhancement of Chinese hamster ovary cells by magnetic microbubbles under different exposure conditions (101). A = non-magnetic microbubbles; B = magnetic micelles; C(i) = magnetic microbubbles. US = ultrasound; MF = magnetic field. Up/down refers to the surface on of the exposure chamber on which the cells were located and hence whether cell/bubble contact would be promoted by buoyancy.

Figure 2. Bioluminescence imaging data for transfection enhancement of Chinese hamster ovary cells by magnetic microbubbles under different exposure conditions (101). A = non-magnetic microbubbles; B = magnetic micelles; C(i) = magnetic microbubbles. US = ultrasound; MF = magnetic field. Up/down refers to the surface on of the exposure chamber on which the cells were located and hence whether cell/bubble contact would be promoted by buoyancy.

Figure 3. (A) Phase contrast and (B) fluorescence (measured at a wavelength of 490/509 nm) microscopy images of the Magnetic and acoustically active liposomes composed of fluidMAG-Tween-60 magnetic nanoparticles and the luciferase plasmid pBLuc, which was fluorescently labelled with the intercalated dye YOYO-1. Reproduced with kind permission from John Wiley & Sons from of reference Citation[106] © 2010 WILEY-VDH Verlag GmbH & Co. KGaA, Weinheim.

Figure 3. (A) Phase contrast and (B) fluorescence (measured at a wavelength of 490/509 nm) microscopy images of the Magnetic and acoustically active liposomes composed of fluidMAG-Tween-60 magnetic nanoparticles and the luciferase plasmid pBLuc, which was fluorescently labelled with the intercalated dye YOYO-1. Reproduced with kind permission from John Wiley & Sons from Figure 2 of reference Citation[106] © 2010 WILEY-VDH Verlag GmbH & Co. KGaA, Weinheim.

Figure 4. Magnetic microbubbles prepared by mixing non-magnetic microbubbles with fluorescently labelled magnetic micelles. (A) retention against flow in a capillary tube following application of a magnetic field (B) fluorescent microbubble obtained by mixing non-fluorescent microbubbles with fluorescent magnetic micelles.

Figure 4. Magnetic microbubbles prepared by mixing non-magnetic microbubbles with fluorescently labelled magnetic micelles. (A) retention against flow in a capillary tube following application of a magnetic field (B) fluorescent microbubble obtained by mixing non-fluorescent microbubbles with fluorescent magnetic micelles.

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