Figures & data
Table 1. Some of the patents related to the oral delivery of proteins and peptides.
Table 2. Polymers used for the coating of nano-carriers encapsulating proteins and peptides.
Teng LL, inventor; Research Corporation, assignee. Orally administered biologically active peptides and proteins. United States patent US 4582820. 1986 April 15 Pather SI, Gupte SV, Khankari RK, et al., inventor; Cima Labs Inc., assignee. Microemulsions as solid dosage forms for oral administration. United States patent 6280770. 1996 August 28 Nomura H, Maruyama K, inventor; Kirin-Amgen, Inc., assignee. Oral dosage form of biologically active proteins. United States patent US 5597562. 1997 January 8 Bernstein H, Morrel E, Mathiowitz E, et al.; Alkermes Controlled Therapeutics, Inc., assignee. Protein microspheres and methods of using them. United States patent US 5679377. October 21, 1997 Ferrari M, Dehlinger P, Martin FJ, et al., inventor; The Regents of the University of California, assignee. Particles for oral delivery of peptides and protein. United States patent US 6355270. 2002 March 12 Michael JC, Litwin A, inventor; The University of Cincinnati, assignee. Oral administration of therapeutic proteins. United States patent US 6613332. 2003 September 2 Plate NA, Valuev LI, Valueva TA, et al., inventor; Ores Pharmaceutical Development Corp., assignee. Polymer composition for oral administration of peptides and proteins. European Patent EP 0918543. 2004 April 21 Takada K, inventor. Oral formulation for gastrointestinal drug delivery. United States patent 7097851. 2006 August 29 Suslick KS, Toublan FJ, Boppart SA, Marks DL, inventors; The Board of Trustees of the University of Illinois, assignee. Surface modified protein microparticles. United States patent US 7217410. 2007 May 15 Shimoni E, Ramon O, Kopelman IJ, et al., inventor; Technion Research and Development Foundation Ltd., assignee. Oral delivery of proteins and peptides. World Intellectual Property Organization WO/2008/132727. 2008 November 6 Radhakrishnan B, Aggarwal D, Ferro M, et al.; Biocon Ltd., assignee. Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof. United States patent 7605123. 2009 October 20 Vol A, Gribova O, inventor; Oshadi Drug Administration Ltd., assignee. Methods and composition for oral administration of protein and peptide therapeutic agents. World Intellectual Property Organization WO2009087633. 2009 July 16 Gupta S, Vyas SP. (2010). Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate. Sci Pharm 78:959–76 Thompson CJ, Tetley L, Cheng WP. (2010). The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin—towards oral insulin delivery. Int J Pharm 383:216–27 Marttin E, Verhoef JC, Merkus FW. (1998). Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs. J Drug Target 6:17–36 Makhlof A, Fujimoto S, Tozuka Y, Takeuchi H. (2011a). In vitro and in vivo evaluation of WGA–carbopol modified liposomes as carriers for oral peptide delivery. Eur J Pharm Biopharm 77:216–24 Shantha KL, Thennarasu S, Krishnamurti N. (1989). Developments and applications of cyanoacrylate adhesives. J Adhes Sci Technol 3:237–60 Serra L, Domenech J, Peppas NA. (2006). Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems. Eur J Pharm Biopharm 63:11–18 Kaur IP, Smitha R. (2002). Penetration enhancer sand ocular bioadhesives: two new avenues for ophthalmic drug delivery. Drug Dev Ind Pharm 28:353–69 Blanco D, Alonso MJ. (1998). Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur J Phar Biopharm 45:285–94 Thompson CJ, Tetley L, Uchegbu IF, Cheng WP. (2009). The complexation between novel comb shaped amphiphilic polyallylamine and insulin—towards oral insulin delivery. Int J Pharm 376:46–55