Oral delivery of therapeutic proteins and peptides: a review on recent developments

References

• Bernstein H, Morrel E, Mathiowitz E, et al.; Alkermes Controlled Therapeutics, Inc., assignee. Protein microspheres and methods of using them. United States patent US 5679377. October 21, 1997
   Google Scholar
• Blanco D, Alonso MJ. (1998). Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur J Phar Biopharm 45:285–94
   PubMed Web of Science ®Google Scholar
• Carvalho FC, Bruschi ML, Evangelista RC, Gremião MPD. (2010). Mucoadhesive drug delivery systems. Braz J Pharm Sci 46:1–17
   Web of Science ®Google Scholar
• Chan JM, Valencia PM, Zhang L, et al. (2010). Polymeric nanoparticles for drug delivery. Methods Mol Biol 624:163–75
   PubMedGoogle Scholar
• Cheng J, Teply BA, Jeong SY, et al. (2006). Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm Res 23:557–64
   PubMed Web of Science ®Google Scholar
• Cheng WP, Thompson C, Ryan SM, et al. (2010). In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes. J Contr Rel 147:289–97
   PubMed Web of Science ®Google Scholar
• de Vries L, Reitzema-Klein CE, Meter-Arkema A, et al. (2010). Oral and pulmonary delivery of thioether-bridged angiotensin-(1–7). Peptides 31:893–8
   PubMed Web of Science ®Google Scholar
• Del Curto MD, Maroni A, Palugan L, et al. (2011). Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds. J Pharm Sci 100:3251–9
   PubMed Web of Science ®Google Scholar
• Dünnhaupta S, Barthelmesa J, Hombach J, et al. (2011). Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa. Int J Pharm 408:191–9
   PubMed Web of Science ®Google Scholar
• Ferrari M, Dehlinger P, Martin FJ, et al., inventor; The Regents of the University of California, assignee. Particles for oral delivery of peptides and protein. United States patent US 6355270. 2002 March 12
   Google Scholar
• Florence AT, Hussain N. (2001). Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev 50:69–89
   PubMed Web of Science ®Google Scholar
• Gupta S, Gabrani R, Ali J, Dang S. (2011). Exploring novel approaches to vaginal drug delivery. Recent Pat Drug Deliv Formul 5:82–94
   PubMedGoogle Scholar
• Gupta S, Vyas SP. (2010). Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate. Sci Pharm 78:959–76
   PubMedGoogle Scholar
• He C, Cui F, Yin L, et al. (2009). A polymeric composite carrier for oral delivery of peptide drugs: bilaminated hydrogel film loaded with nanoparticles. Eur Polymer Journal 45:368–76
   Web of Science ®Google Scholar
• Hussain N, Florence AT. (1998). Utilizing bacterial mechanisms of epithelial cell entry: invasin-induced oral uptake of latex nanoparticles. Pharm Res 15:153–6
   PubMed Web of Science ®Google Scholar
• Jin X, Xua Y, Shena J, et al. (2011). Chitosan-glutathione conjugate-coated poly (butyl cyanoacrylate) nanoparticles: Promising carriers for oral thymopentin delivery. Carbohydr Polym 86:51–7
   Web of Science ®Google Scholar
• Kafka AP, McLeod BJ, Radesa T, McDowell A. (2011). Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control. J Contr Rel 149:307–13
   PubMed Web of Science ®Google Scholar
• Kaur IP, Smitha R. (2002). Penetration enhancer sand ocular bioadhesives: two new avenues for ophthalmic drug delivery. Drug Dev Ind Pharm 28:353–69
   PubMed Web of Science ®Google Scholar
• Khafagy ES, Morishita M. (2012). Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev 64:531–9
   PubMed Web of Science ®Google Scholar
• Kilpelainen M, Monkarea J, Vlasova MA, et al. (2011). Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery. Eur J Pharm Biopharm 77:20–5
   PubMed Web of Science ®Google Scholar
• Lee HE, Lee MJ, Park CR, et al. (2010). Preparation and characterization of salmon calcitonin–sodium triphosphate ionic complex for oral delivery. J Contr Rel 143:251–7
   PubMed Web of Science ®Google Scholar
• Li Z, Chen J, Sun W, Xu Y. (2010). Investigation of archaeosomes as carriers for oral delivery of peptides. Biochem Biophys Res Commun 394:412–17
   PubMed Web of Science ®Google Scholar
• Liang JF, Yang VC. (2005). Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochem Biophys Res Commun 335:734–8
   PubMed Web of Science ®Google Scholar
• Liu C, Tan Y, Liu C, et al. (2007). Preparations, characterizations and applications of chitosan-based nanoparticles. J Ocean Univ China 6:237–43
   Google Scholar
• Madhav NVS, Kala S. (2011). Review on microparticulate drug delivery system. Int J PharmTech Res 3:1242–54
   Google Scholar
• Makhlof A, Fujimoto S, Tozuka Y, Takeuchi H. (2011a). In vitro and in vivo evaluation of WGA–carbopol modified liposomes as carriers for oral peptide delivery. Eur J Pharm Biopharm 77:216–24
   PubMed Web of Science ®Google Scholar
• Makhlof A, Tozuka Y, Takeuchi H. (2011b). Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci 42:445–51
   PubMed Web of Science ®Google Scholar
• Makhlof A, Werlea M, Tozukaa Y, Takeuchi H. (2011c). A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa. J Contr Rel 149:81–8
   PubMed Web of Science ®Google Scholar
• Marks FM, Lowman A. (2011). Enhanced mucoadhesive capacity of novel co-polymers for oral protein delivery. J Biomater Sci Polym Ed 22:2079–95
   PubMed Web of Science ®Google Scholar
• Marttin E, Verhoef JC, Merkus FW. (1998). Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs. J Drug Target 6:17–36
   PubMed Web of Science ®Google Scholar
• Michael JC, Litwin A, inventor; The University of Cincinnati, assignee. Oral administration of therapeutic proteins. United States patent US 6613332. 2003 September 2
   Google Scholar
• Nomura H, Maruyama K, inventor; Kirin-Amgen, Inc., assignee. Oral dosage form of biologically active proteins. United States patent US 5597562. 1997 January 8
   Google Scholar
• Pather SI, Gupte SV, Khankari RK, et al., inventor; Cima Labs Inc., assignee. Microemulsions as solid dosage forms for oral administration. United States patent 6280770. 1996 August 28
   Google Scholar
• Peppas NA, Robinson JR. (1995). Bioadhesives for optimization of drug delivery. J Drug Target 3:183–4
   PubMed Web of Science ®Google Scholar
• Plate NA, Valuev LI, Valueva TA, et al., inventor; Ores Pharmaceutical Development Corp., assignee. Polymer composition for oral administration of peptides and proteins. European Patent EP 0918543. 2004 April 21
   Google Scholar
• Porter CJH, Charman WN. (1997). Uptake of drugs into the intestinal lymphatics after oral administration. Adv Drug Del Rev 25:71–89
   Web of Science ®Google Scholar
• Qi X, Wang L, Zhu J, et al. (2011). Self-double-emulsifying drug delivery system (SDEDDS): A new way for oral delivery of drugs with high solubility and low permeability. Int J Pharm 409:245–51
   PubMed Web of Science ®Google Scholar
• Rabanel JM, Elkin V, Mokhtar M, Hildgen P. (2012). Drug-loaded nanocarriers: passive targeting and crossing of biological barriers. Curr Med Chem 19:3070–102
   PubMed Web of Science ®Google Scholar
• Radhakrishnan B, Aggarwal D, Ferro M, et al.; Biocon Ltd., assignee. Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof. United States patent 7605123. 2009 October 20
   Google Scholar
• Rekha MR, Sharma CP. (2009). Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J Contr Rel 135:144–51
   PubMed Web of Science ®Google Scholar
• Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. (1999). In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569–72
   PubMed Web of Science ®Google Scholar
• Senel S, Kremer MJ, Kas S, et al. (2000). Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. Biomaterials 21:2067–71
   PubMed Web of Science ®Google Scholar
• Serra L, Domenech J, Peppas NA. (2006). Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems. Eur J Pharm Biopharm 63:11–18
   PubMed Web of Science ®Google Scholar
• Shantha KL, Thennarasu S, Krishnamurti N. (1989). Developments and applications of cyanoacrylate adhesives. J Adhes Sci Technol 3:237–60
   Web of Science ®Google Scholar
• Sharma A, Sharma US. (2011). Liposomes in drug delivery: Progress and limitations. Int J Pharm 154:123–40
   Google Scholar
• Shimoni E, Ramon O, Kopelman IJ, et al., inventor; Technion Research and Development Foundation Ltd., assignee. Oral delivery of proteins and peptides. World Intellectual Property Organization WO/2008/132727. 2008 November 6
   Google Scholar
• Shukla A, Singh B, Katare OP. (2011). Significant systemic and mucosal immune response induced on oral delivery of diphtheria toxoid using nano-bilosomes. Br J Pharmacol 164:820–7
   PubMed Web of Science ®Google Scholar
• Sonia TA, Sharma CP. (2011). In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery. Carbohydr Polym 84:103–9
   Web of Science ®Google Scholar
• Suksamran T, Opanasopit P, Rojanarata T, et al. (2009). Biodegradable alginate microparticles developed by electrohydrodynamic spraying techniques for oral delivery of proteins. J Microencapsul 26:563–70
   PubMed Web of Science ®Google Scholar
• Suslick KS, Toublan FJ, Boppart SA, Marks DL, inventors; The Board of Trustees of the University of Illinois, assignee. Surface modified protein microparticles. United States patent US 7217410. 2007 May 15
   Google Scholar
• Takada K, inventor. Oral formulation for gastrointestinal drug delivery. United States patent 7097851. 2006 August 29
   Google Scholar
• Teng LL, inventor; Research Corporation, assignee. Orally administered biologically active peptides and proteins. United States patent US 4582820. 1986 April 15
   Google Scholar
• Thompson CJ, Tetley L, Cheng WP. (2010). The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin—towards oral insulin delivery. Int J Pharm 383:216–27
   PubMed Web of Science ®Google Scholar
• Thompson CJ, Tetley L, Uchegbu IF, Cheng WP. (2009). The complexation between novel comb shaped amphiphilic polyallylamine and insulin—towards oral insulin delivery. Int J Pharm 376:46–55
   PubMedGoogle Scholar
• Trapani A, Lopedota A, Franco M, et al. (2010). A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides. Eur J Pharm Biopharm 75:26–32
   PubMed Web of Science ®Google Scholar
• Vol A, Gribova O, inventor; Oshadi Drug Administration Ltd., assignee. Methods and composition for oral administration of protein and peptide therapeutic agents. World Intellectual Property Organization WO2009087633. 2009 July 16
   Google Scholar
• Wang T, Wang N, Hao A, et al. (2010). Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery. Eur J Pharm Biopharm 39:373–9
   Web of Science ®Google Scholar
• Werle M, Takeuchi H. (2009). Chitosan–aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation. Int J Pharm 370:26–32
   PubMed Web of Science ®Google Scholar
• Yina L, Dinga J, He C, et al. (2009). Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30:5691–700
   PubMed Web of Science ®Google Scholar
• Yousefpour P, Atyabi F, Farhani EV, et al. (2011). Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: in vitro analysis and evaluations. Int J Nanomedicine 6:1487–96
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wei W, Lv P, et al. (2011). Preparation and evaluation of alginate–chitosan microspheres for oral delivery of insulin. Eur J Pharm Biopharm 77:11–19
   PubMed Web of Science ®Google Scholar