Figures & data
Figure 3. DSC analyses of the samples: (A) ACM, (B) blank SLNs, (C) physical mixture of ACM and blank SLNs, (D) ACM-SLNs.
![Figure 3. DSC analyses of the samples: (A) ACM, (B) blank SLNs, (C) physical mixture of ACM and blank SLNs, (D) ACM-SLNs.](/cms/asset/2b247b99-595a-4c42-b9f8-27dfdcab12a9/idrd_a_974001_f0003_b.jpg)
Figure 4. X-ray diffraction spectra of (A) ACM, (B) physical mixture of ACM and blank SLNs, (C) blank SLNs, and (D) ACM-SLNs.
![Figure 4. X-ray diffraction spectra of (A) ACM, (B) physical mixture of ACM and blank SLNs, (C) blank SLNs, and (D) ACM-SLNs.](/cms/asset/7bdd2e32-1c5e-4118-881d-b7796153afd8/idrd_a_974001_f0004_b.jpg)
Figure 5. In vitro release profiles of ACM-SLNs from three batches. Release experiments were carried out in phosphate buffer solution (PBS) (pH 7.4), at 37 ± 0.5 °C. Each point represents the mean value of three different experiments ± SD ⋄, free ACM; △, ACM-SLNs; *p < 0.05 free ACM versus ACM-SLNs.
![Figure 5. In vitro release profiles of ACM-SLNs from three batches. Release experiments were carried out in phosphate buffer solution (PBS) (pH 7.4), at 37 ± 0.5 °C. Each point represents the mean value of three different experiments ± SD ⋄, free ACM; △, ACM-SLNs; *p < 0.05 free ACM versus ACM-SLNs.](/cms/asset/64e14b9c-8899-4fcf-be3c-9bbfb493baee/idrd_a_974001_f0005_b.jpg)
Table 1. Correlation coefficients for kinetic analysis of release data for ACM-SLNs.
Figure 6. Mean plasma concentration–time profiles of ACM after i.v. administration of a single 10 mg/kg dose of free ACM and ACM-SLNs to rats. The values are expressed as mean ± SD (n = 6).
![Figure 6. Mean plasma concentration–time profiles of ACM after i.v. administration of a single 10 mg/kg dose of free ACM and ACM-SLNs to rats. The values are expressed as mean ± SD (n = 6).](/cms/asset/020c0b9e-2d43-4d5b-a48c-fff04a190f84/idrd_a_974001_f0006_b.jpg)
Table 2. Pharmacokinetic parameters of the two formulations.
Figure 7. Distribution in tissue in rats after following i.v. administration of a single 10 mg/kg dose of ACM injection tissues (ng/g) (each point represents the mean ± SD of six rats).
![Figure 7. Distribution in tissue in rats after following i.v. administration of a single 10 mg/kg dose of ACM injection tissues (ng/g) (each point represents the mean ± SD of six rats).](/cms/asset/ba4f03d4-cee2-4838-b03d-96cab2c00194/idrd_a_974001_f0007_b.jpg)
Figure 8. Distribution in tissue in rats after following i.v. administration of a single 10 mg/kg dose of ACM-SLNs tissues (ng/g) (each point represents the mean ± SD of six rats).
![Figure 8. Distribution in tissue in rats after following i.v. administration of a single 10 mg/kg dose of ACM-SLNs tissues (ng/g) (each point represents the mean ± SD of six rats).](/cms/asset/b2dfdb5c-66b6-4426-a7ee-a58043bbf7af/idrd_a_974001_f0008_b.jpg)