Figures & data
Table 1. Composition of different docetaxel LNEs.
Table 2. Physical characters of the prepared DLNEs (n = 3).
Table 3. Estimation of amount of albumin bound to each globule of docetaxel LNE.
Figure 2. In vitro cytotoxic study-a comparison of IC50 values of DLNE on Hela and MCF-7 cell lines (Mean ± SD, n = 6). (DLNE: Docetaxel lipid nanoemulsion, SALNE: stearyl amine containing lipid nanoemulsion, ALNE: albumin containing lipid nanoemulsion, DS: drug solution).
![Figure 2. In vitro cytotoxic study-a comparison of IC50 values of DLNE on Hela and MCF-7 cell lines (Mean ± SD, n = 6). (DLNE: Docetaxel lipid nanoemulsion, SALNE: stearyl amine containing lipid nanoemulsion, ALNE: albumin containing lipid nanoemulsion, DS: drug solution).](/cms/asset/4b850291-9cce-4890-8648-e1eb348b9d30/idrd_a_1030715_f0002_c.jpg)
Figure 3. Fluorescence emitted from the mice after 6 h of administration of different LNEs. (Note: Encircled areas depict the tumors. The increased fluorescence intensity is observed when compared with control animal (before treatment), after the administration of DiD oil-loaded DLNE, SALNE and ALNE.
![Figure 3. Fluorescence emitted from the mice after 6 h of administration of different LNEs. (Note: Encircled areas depict the tumors. The increased fluorescence intensity is observed when compared with control animal (before treatment), after the administration of DiD oil-loaded DLNE, SALNE and ALNE.](/cms/asset/8846066c-8887-48b6-94d8-5b8ffdab328f/idrd_a_1030715_f0003_c.jpg)
Figure 4. A comparison: fluorescent images of the major organs/tissues after 6 h of administration of different LNEs in tumor-induced mice.
![Figure 4. A comparison: fluorescent images of the major organs/tissues after 6 h of administration of different LNEs in tumor-induced mice.](/cms/asset/d518064c-1a16-45f2-94e5-23a65e862f8e/idrd_a_1030715_f0004_c.jpg)
Table 4. Average radiance values of the major organs/tissues after 6 h of administration of different docetaxel LNEs (n = 3) containing fluorescent DiD oil.
Figure 6. Bar diagram showing a comparative reduction in final tumor weights after four treatments with various LNEs (n = 6). Note: *Statistically significant when compared with control at p < 0.01. #Statistically significant when compared with DLNE at p < 0.01. $Statistically significant when compared with SALNE at p < 0.01.
![Figure 6. Bar diagram showing a comparative reduction in final tumor weights after four treatments with various LNEs (n = 6). Note: *Statistically significant when compared with control at p < 0.01. #Statistically significant when compared with DLNE at p < 0.01. $Statistically significant when compared with SALNE at p < 0.01.](/cms/asset/e52e0176-5a23-477a-bdfc-c3d98d3f8b3b/idrd_a_1030715_f0006_c.jpg)