Analysis of relationships between the concentrations of total testosterone and dehydroepiandrosterone sulfate and the occurrence of selected metabolic disorders in aging men

Figures & data

Table 1. Characteristics of the study group.

Parameter	n	AM ± SD	Med	Range
Height (m)	313	175.2 ± 0.6	175.0	158.0–194.0
Body weight (kg)	313	87.0 ± 15.0	85.0	52.0–135.0
BMI (mg/m^2)	313	28.3 ± 7.7	27.7	19.5–46.7
WC (cm)	313	102.0 ± 12.0	100.0	75.0–146.0
HC (cm)	313	103.0 ± 8.0	103.0	82.0–129.0
WHR	313	1.0 ± 0.1	1.0	0.8–1.2
ABP systolic (mmHg)	313	135.0 ± 20.0	135.0	80.0–220.0
ABP diastolic (mmHg)	313	84.0 ± 20.0	80.0	50.0–140.0
TT (ng/ml)	313	3.9 ± 1.6	3.5	0.6–9.8
FT (pg/ml)	313	105.2 ± 58.1	95.9	6.7–423.7
SHBG (nmol/l)	313	45.3 ± 24.3	42.3	3.9–192.0
E2 (pg/ml)	313	39.1 ± 21.5	35.4	5.6–133.7
DHEAS (μg/ml)	313	1.49 ± 0.84	1.3	0.01–4.61
TG (mg/dl)	313	144.4 ± 83.6	121.0	37.0–581.0
TCh (mg/dl)	313	219.0 ± 57.1	217.0	96.0–416.0
LDL (mg/dl)	313	142.0 ± 54.0	138.0	20.0–342.0
HDL (mg/dl)	313	48.6 ± 12.4	47.0	19.0–95.0
FPG (mg/dl)	313	107.0 ± 21.5	104.0	53.0–237.0
I (μIU/ml)	257	14.8 ± 7.7	13.4	1.2–66.4
HOMA–IR	257	4.0 ± 2.2	3.4	0.3–15.8

AM, arithmetic mean; SD, standard deviation; Med, median; BMI, Body Mass index; WC, Waist circumference; HC, Hip circumference; WHR, waist-to-hip ratio; ABP, arterial blood pressure; TT, total testosterone; FT, free testosterone; SHBG, sex hormone binding globulin; E₂, estradiol; DHEAS, dehydroepiandrosterone sulfate; TG, triglyceride; TCh, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FPG, fasting plasma glucose; I, serum insulin levels; HOMA–IR, Homeostasis Model Assessment–insulin resistance.

Table 2. The concentration of dehydroepiandrosterone sulfate (DHEAS) and total testosterone (TT) in relation to diseases and health problems in a study group.

	DHEAS		TT
Qualitative variables	AM ± SD (μg/ml)	p	AM ± SD (ng/ml)	p
MetS (n = 161)	1.34 ± 0.78	0.51	3.40 ± 1.33	<0.0001
Without MetS (n = 152)	1.41 ± 0.88		4.36 ± 1.76
T2DM (n = 55)	1.35 ± 0.80	0.17	3.48 ± 1.53	0.06
Without T2DM (n = 258)	1.52 ± 0.98		3.94 ± 1.63
HT (n = 171)	1.26 ± 0.78	0.008	3.43 ± 1.42	<0.0001
Without HT (n = 142)	1.52 ± 0.88		4.38 ± 1.71
Statin treatment (n = 49)	1.12 ± 0.59	0.019	3.70 ± 1.58	0.48
No statin treatment (n = 264)	1.43 ± 0.87		3.91 ± 1.64
Smoking (n = 51)	1.51 ± 0.84	0.13	3.89 ± 1.85	0.79
No smoking (n = 262)	1.45 ± 0.88		3.81 ± 1.58
Normal body weight (n = 62)	1.35 ± 0.80	p (0–1) = 0.68	4.67 ± 0.68	p (0–1) = 0.004
Overweight (n = 164)	1.30 ± 0.79	p (0–2) = 0.18	3.97 ± 1.53	p (0–2) < 0.0001
Obesity (n = 87)	1.46 ± 0.93	p (1–2) = 0.09	3.11 ± 0.86	p (1–2) < 0.0001

DHEAS, dehydroepiandrosterone sulfate; TT, total testosterone; AM, arithmetic mean; SD, standard deviation; p, probability for trend; MetS, metabolic syndrome; T2DM, type 2 diabetes mellitus; HT, hypertension.

Table 3. Spearman correlation coefficients between age, anthropometric and biochemical parameters and the serum dehydroepiandrosterone sulfate (DHEAS) and total testosterone (TT).

	DHEAS		TT
Parameter	rs	p	rs	p
Age	−0.310	<0.0001	0.07	0.22
Body weight	0.077	0.17	−0.365	<0.0001
BMI	0.022	0.69	−0.406	<0.0001
WC	0.139	0.80	−0.377	<0.0001
HC	−0.034	0.80	−0.297	<0.0001
WHR	0.060	0.28	−0.352	<0.0001
ABP systolic	−0.040	0.47	−0.075	0.18
ABP diastolic	0.035	0.53	−0.089	0.11
TG	0.084	0.14	−0.314	<0.0001
TCh	0.209	0.0002	0.059	0.30
HDL	−0.069	0.22	0.197	0.0004
LDL	0.209	0.0002	0.081	0.15
FPG	−0.020	0.74	−0.145	0.02
I	0.075	0.53	−0.263	<0.0001
HOMA–IR	0.068	0.27	−0.291	<0.0001

DHEAS, dehydroepiandrosterone sulfate; TT, total testosterone; BMI, Body Mass index; WC, waist circumference; HC, hip circumference; WHR, waist-to-hip ratio; ABP, arterial blood pressure; TG, triglyceride; TCh, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FPG, fasting plasma glucose; I, serum insulin levels; HOMA–IR, Homeostasis Model Assessment–insulin resistance; p, probability for trend.