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Research Article

Chlorogenic acid protects d-galactose-induced liver and kidney injury via antioxidation and anti-inflammation effects in mice

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Pages 1027-1034 | Received 13 May 2015, Accepted 08 Sep 2015, Published online: 25 Jan 2016

Figures & data

Figure 1. Effect of CGA on d-gal-induced changes in hepatic (A) and renal (B and C) functional markers. All data are represented as mean ± SD (n = 6). *<0.05 as compared with the control group; #<0.05 as compared with the d-gal group.

Figure 1. Effect of CGA on d-gal-induced changes in hepatic (A) and renal (B and C) functional markers. All data are represented as mean ± SD (n = 6). *p <0.05 as compared with the control group; #p <0.05 as compared with the d-gal group.

Figure 2. Effect of CGA on histopathological changes of the d-gal-treated mouse liver (A) and kidney (B), (n = 4). Arrow indicated to the structure damage, degeneration, and necrosis of hepatocytes and nephrocytes. Original magnification, 10 × 40.

Figure 2. Effect of CGA on histopathological changes of the d-gal-treated mouse liver (A) and kidney (B), (n = 4). Arrow indicated to the structure damage, degeneration, and necrosis of hepatocytes and nephrocytes. Original magnification, 10 × 40.

Figure 3. Effects of CGA on the levels of malondialdehyde (MDA) (A and B) and glutathione (GSH) (C and D) and the activities of superoxide dismutase (SOD) (E and F) and catalase (CAT) (G and H) in the liver and kidney of mice. All values are expressed as mean ± SD (n = 6).

Figure 3. Effects of CGA on the levels of malondialdehyde (MDA) (A and B) and glutathione (GSH) (C and D) and the activities of superoxide dismutase (SOD) (E and F) and catalase (CAT) (G and H) in the liver and kidney of mice. All values are expressed as mean ± SD (n = 6).

Figure 4. Effect of CGA on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in the liver (A) and kidney (B) of d-gal-induced mice. Values are expressed as mean ± SD (n = 6).

Figure 4. Effect of CGA on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in the liver (A) and kidney (B) of d-gal-induced mice. Values are expressed as mean ± SD (n = 6).

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