The hypolipidemic activity of novel benzofuran-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats: a comparison with bezafibrate

Figures & data

Figure 1.  Chemical structures of compound 4 [N-(9,10-dihydro-9,10-dioxoanthracen-2-yl)benzofuran-2-carboxamide] and compound 5 [N-(4-benzoylphenyl)benzofuran-2-carboxamide].

Scheme 1.  Synthesis route for the preparation of compounds 4 and 5. Reagents and conditions: (a) dichloromethane, reflux 6 h; (b) triethylamine; (c), (d) N,N-dimethylformamide, 24 h.

Figure 2.  Effect of Triton WR-1339 on lipid profile after (a) 7 h and (b) 24 h. Values are mean ± SEM from six animals in each group. CG, control group; HG, hyperlipidemic control group; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. HG is compared to CG: ^*p < 0.05, ^**p < 0.0001.

Table 1.  Effect of compounds 4, 5, and bezafibrate on plasma lipid levels in Triton WR-1339-induced hyperlipidemic rats after 7 h and 24 h.

Lipid profile	TC (mg/dL)	TG (mg/dL)	HDL-C (mg/dL)	LDL-C (mg/dL)
7 h
HG	116.50 ± 7.9	540.50 ± 34.7	28.50 ± 2.6	20.00 ± 3.2
Compound 4	95.00 ± 10.1^a	107.00 ± 7.2^c	60.00 ± 6.6^c	13.67 ± 3.2^a
Compound 5	57.30 ± 5.3^c	35.50 ± 3.2^c	42.33 ± 4.2^b	8.33 ± 2.6^c
BF	101.16 ± 6.9	181.83 ± 11.2^c	51.17 ± 5.6^c	13.17 ± 1.9^a
24 h
HG	96.83 ± 8.4	435.67 ± 25.3	35.33 ± 6.4	18.67 ± 4.2
Compound 4	88.30 ± 4.1^a	141.00 ± 13.7^c	45.00 ± 2.0^a	15.10 ± 2.6
Compound 5	88.33 ± 8.9^a	140.50 ± 10.5^c	43.17 ± 2.9^a	12.00 ± 1.4^a
BF	100.00 ± 6.8	189.17 ± 11.2^c	46.83 ± 2.2^a	15.33 ± 2.7

Note. Values are mean ± SEM from six animals in each group. HG, hyperlipidemic control group; compound 4, N-(9,10-dihydro-9,10-dioxoanthracen-2-yl)benzofuran-2-carboxamide treated group; compound 5, N-(4-benzoylphenyl)benzofuran-2-carboxamide treated group; BF, bezafibrate treated group; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.

^ap < 0.001, ^bp < 0.001, ^cp < 0.0001: compounds 4, 5, and BF are compared with HG.