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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 25, 2010 - Issue 6
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Research Article

Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study

Ebru AkkemikAtaturk University, Science Faculty, Department of Chemistry; Erzurum, Turkey
,
Harun BudakAtaturk University, Science Faculty, Department of Chemistry; Erzurum, Turkey
&
Mehmet CiftciAtaturk University, Science Faculty, Department of Chemistry; Erzurum, TurkeyCorrespondence[email protected]
Pages 871-875 | Received 24 Aug 2009, Accepted 10 Nov 2009, Published online: 08 Nov 2010

Figures & data

Figure 1.  Activity % vs [Ketotifen] regression analysis graphs for human erythrocytes G6PD in the presence of 5 different ketotifen concentrations.

Figure 1.  Activity % vs [Ketotifen] regression analysis graphs for human erythrocytes G6PD in the presence of 5 different ketotifen concentrations.

Figure 2.  Lineweaver-Burk graph for 5 different substrate (G6P) concentrations and 3 different ketotifen concentrations for determination of Ki.

Figure 2.  Lineweaver-Burk graph for 5 different substrate (G6P) concentrations and 3 different ketotifen concentrations for determination of Ki.

Table I.  Purification scheme of G6PD dehydrogenase from human erythrocyte.

Table II.  IC50 values and Ki constants obtained from inhibition percent values vs five different inhibitors concentrations and Lineweaver–Burk graphs respectively in the presence of three fixed inhibitors and five substrate concentrations for different drugs.

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