Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro

Figures & data

Figure 1.  Molecular structure of antibiotics (A) sodium ampicillin, (B) clindamiycin phosphate, (C) Rifamycin SV and (D) ciprofloxacin.

Table 1.  The IC₅₀ values of antibiotics on paraoxonase activity in HepG2 cells (2, 4 and 6 h at time points after the drug application).

Antibiotic	IC50.μg/mL
	2 h	4 h	6 h
Sodium ampicillin	47.43	44.23	32.66
Clindamiycin phosphate	28.06	54.33	21.75
Rifamycin SV	8.94	2.11	2.65
Ciprofloxacin	139.3	132.5	239.5

Figure 2.  2h (A), 4h (B) and 6h (C) effects of sodium ampicillin (I), ciprofloxacin (II), Rifamycin SV (III), clindamiycin phosphate (IV) on paraoxonase activity for HepG2.