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Research Article

Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators

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Pages 93-97 | Received 28 Nov 2009, Accepted 26 Feb 2010, Published online: 22 Jun 2010

Figures & data

Figure 1. The structures of the drugs used in the experiments.

Figure 1.  The structures of the drugs used in the experiments.

Figure 2. The influence of oximes on (A) AChE activity and (B) LMWA levels. The samples were obtained from (numbered according bar): 1 – controls (intact rats); 2 – rats treated by atropine; 3 – rats exposed to tabun and treated by atropine; 4–8 rats exposed to tabun and treated by atropine combined with HI-6 dichloride (4), obidoxime (5), trimedoxime (6), K203 (7), KR-22836 (8). Asterisks indicate significance (ANOVA with Scheffe test, p ≤ 0.05) against control (bar 1). When a fraction is presented the asterisk in the numerator indicates significance against the control and an asterisk in the denominator indicates significance against the tabun exposed rats (bar 3). A stroke indicates no significance. The error bars indicate the standard error of mean (SEM) for n = 8.

Figure 2.  The influence of oximes on (A) AChE activity and (B) LMWA levels. The samples were obtained from (numbered according bar): 1 – controls (intact rats); 2 – rats treated by atropine; 3 – rats exposed to tabun and treated by atropine; 4–8 rats exposed to tabun and treated by atropine combined with HI-6 dichloride (4), obidoxime (5), trimedoxime (6), K203 (7), KR-22836 (8). Asterisks indicate significance (ANOVA with Scheffe test, p ≤ 0.05) against control (bar 1). When a fraction is presented the asterisk in the numerator indicates significance against the control and an asterisk in the denominator indicates significance against the tabun exposed rats (bar 3). A stroke indicates no significance. The error bars indicate the standard error of mean (SEM) for n = 8.

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