Views

CrossRef citations to date

Altmetric

Original Article

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents

Kondapalli Venkata Gowri Chandra SekharChemistry Group, Birla Institute of Technology & Science, Pilani, Rajasthan, IndiaCorrespondence[email protected]

Vajja Samabasiva RaoChemistry Group, Birla Institute of Technology & Science, Pilani, Rajasthan, India

Winnie Deuther-ConradForschungszentrum Dresden–Rossendorf, Interdisciplinary Isotope Research, Institute of Radiopharmacy, Leipzig, Germany

Aravalli Satish ReddyChemistry Group, Birla Institute of Technology & Science, Pilani, Rajasthan, India

Peter BrustForschungszentrum Dresden–Rossendorf, Interdisciplinary Isotope Research, Institute of Radiopharmacy, Leipzig, Germany

Mutyala Murali Krishna KumarChemistry Group, Birla Institute of Technology & Science, Pilani, Rajasthan, India

Figures & data

Scheme 1. Synthesis of chloroethylphenylthiazoles (1–7).

Scheme 2. Synthesis of 2-(piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile (9).

Scheme 3. Synthesis of 2-{4-[4-(2,5-disubstituted thiazolyl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles (10a–g).

Table 1. Summary of in vitro radioligand displacement studies of final compounds (n = 3) (10a–g).

Download CSV Display Table

Table 2. Results of D₂ and 5-HT_2A antagonism studies of final compounds (10a–g).

Download CSV Display Table

Table 3. Results of D₂ and 5-HT_2A antagonism studies, catalepsy test of final compounds (10a–g).

Download CSV Display Table

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents

Table 1. Summary of in vitro radioligand displacement studies of final compounds (n = 3) (10a–g).

Table 2. Results of D₂ and 5-HT_2A antagonism studies of final compounds (10a–g).

Table 3. Results of D₂ and 5-HT_2A antagonism studies, catalepsy test of final compounds (10a–g).

Related Research Data

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents

Figures & data

Table 1. Summary of in vitro radioligand displacement studies of final compounds (n = 3) (10a–g).

Table 2. Results of D2 and 5-HT2A antagonism studies of final compounds (10a–g).

Table 3. Results of D2 and 5-HT2A antagonism studies, catalepsy test of final compounds (10a–g).

Reprints and Corporate Permissions

Academic Permissions

Related Research Data

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Table 2. Results of D₂ and 5-HT_2A antagonism studies of final compounds (10a–g).

Table 3. Results of D₂ and 5-HT_2A antagonism studies, catalepsy test of final compounds (10a–g).