Evaluation of the inhibitory potential of five squaric acid derivatives against pancreatic lipase

Figures & data

Scheme 1.  General procedure for the synthesis of 4-amino-3-ethoxy-3-cyclobutene-1,2-diones.

Figure 1.  IC₅₀ for dihydroxy-(A), diethoxy-(B) derivatives of cyclobutendione, the newly synthesized compounds (1)–(5), and Orlistat. IC₅₀ is the concentration of tested compound required for a 50% inhibition of the lipase activity. Data are presented ±standard deviation.

Figure 2.  The dependence of the inhibitory activity of 3-ethoxy-4-(hexadecylamino)-3-cyclobutene-1,2-dione (1) and squaric acid from the incubation time. Solid squares, squaric acid; solid circles, compound 1.