Figures & data
Figure 1. (a) Reported bromopyrrole alkaloids and aroyl hydrazones with antibacterial and antibiofilm activities. (b) Design of novel N′-arylidene-4,5-dibromo-1-methyl-1H-pyrrole-2-carbohydrazides using molecular hybridization approach.
Table 1. Antibacterial and antibiofilm test results*.
Table 2. Screening of various staphylococcal strains for biofilm formation by TCP method in tryticase soy broth with 1% glucose at 18 and 24 h of incubation.
Figure 2. (a) Evaluation of antibiofilm activity of compound 4m by Log reduction in viable counts of MSSA (ATCC 35556). (b) Evaluation of antibiofilm activity of compound 4m by Log reduction in viable counts of MRSA (ATCC 43866). (c) Evaluation of antibiofilm activity of compound 4m by Log reduction in viable counts of SE (ATCC 35984).
Scheme 1. Synthesis of N′-arylidene-4,5-dibromo-1-methyl-1H-pyrrole-2-carbohydrazides.
