Design, synthesis, and antitumor screening of certain novel tetrahydroquinoline sulfonamides

Figures & data

Scheme 1. Synthesis of the target tetrahydroquinoline derivatives 16–23.

Table 1. In vitro antitumor activity of the designed tetrahydroquinoline derivatives 4–23.

	IC50 (μM)
Cpd no.	MCF-7*	HeLa†	HepG2‡
4	0.011	0.013	0.009
5	0.012	0.012	0.011
6	0.013	0.013	0.013
7	0.005	0.003	0.014
8	0.015	0.013	0.014
9	0.004	0.004	0.004
10	0.009	0.008	0.009
11	0.011	0.011	0.011
12	0.004	0.004	0.004
13	0.005	0.005	0.006
14	0.008	0.008	0.009
15	0.009	0.009	0.009
16	0.011	0.011	0.011
17	0.005	0.005	0.006
18	0.006	0.006	0.006
19	0.011	0.011	0.011
20	0.009	0.009	0.008
21	0.005	0.005	0.003
22	0.006	0.006	0.007
23	0.006	0.007	0.006
DOX	0.007	0.008	0.007

*Human breast cancer cell line (MCF-7).

†Human cervical cancer cell line (HeLa).

‡Human hepatocellular liver carcinoma cell line (HepG2).