The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives

Figures & data

Figure 1. The chemical structures of trimethoxyindane derivatives (1–9) used for carbonic anhydrase isoenzymes (hCA I and II) and acetylcholine esterase enzyme (AChE) inhibition effects.

Table 1. Human carbonic anhydrase isoenzymes (hCA I and II) and acetylcholine esterase enzyme (AChE) inhibition effects of trimethoxyindane derivatives (1–9).

	IC50 (nM)						Ki (nM)
Trimethoxyindane derivatives	hCA I	r^2	hCA II	r^2	AChE	r^2	hCA I	hCA II	AChE
1	3.57	0.9740	3.11	0.9968	5.97	0.9532	4.14 ± 1.29	3.12 ± 0.61	7.53 ± 2.91
2	3.62	0.9922	2.64	0.9588	5.17	0.9367	3.86 ± 1.62	2.02 ± 0.19	7.14 ± 3.22
3	1.84	0.9921	1.44	0.9982	3.11	0.9400	1.66 ± 0.36	1.37 ± 0.31	1.87 ± 0.84
4	3.01	0.9974	1.91	0.9931	4.59	0.9536	2.91 ± 0.71	1.68 ± 0.01	2.83 ± 1.02
5	3.76	0.9935	2.17	0.971	5.68	0.9605	3.21 ± 0.51	1.90 ± 0.43	6.67 ± 2.86
6	2.40	0.9776	1.65	0.9937	3.91	0.9623	2.04 ± 0.60	1.89 ± 0.46	4.67 ± 2.07
7	3.11	0.9814	2.38	0.9953	5.68	0.9617	2.39 ± 0.68	3.11 ± 0.54	3.99 ± 1.43
8	1.89	0.9958	1.39	0.9909	3.17	0.9790	1.66 ± 0.21	1.46 ± 0.21	2.10 ± 0.72
9	2.87	0.9969	2.11	0.9895	4.68	0.9710	2.64 ± 0.53	2.21 ± 0.37	3.39 ± 1.11
AZA*	6.07	0.9154	5.50	0.9636	–	–	6.76 ± 2.55	5.85 ± 2.56	–
Tacrine*	–	–	–	–	7.53	0.9066	–	–	7.64 ± 3.74

*Acetazolamide (AZA) was used as a standard inhibitor for all CAs and Tacrine was used as a standard inhibitor for acetylcholine esterase (AChE) enzyme.