Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 1 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 1 (2016)

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Review Article

Natural, semisynthetic and synthetic tyrosinase inhibitors
Sang Yeul Lee, Namhuk Baek & Tae-gyu Nam
Pages: 1-13
Published online: 16 Feb 2015
AbstractforNatural, semisynthetic and synthetic tyrosinase inhibitors | Full Text | References | PDF (1.3 MB)
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Research Article

Article
Biological evaluation and molecular modelling study of thiosemicarbazide derivatives as bacterial type IIA topoisomerases inhibitors
Agata Paneth, Paweł Stączek, Tomasz Plech, Aleksandra Strzelczyk, Katarzyna Dzitko, Monika Wujec, Edyta Kuśmierz, Urszula Kosikowska, Agnieszka Grzegorczyk & Piotr Paneth
Pages: 14-22
Published online: 20 Mar 2015
AbstractforBiological evaluation and molecular modelling study of thiosemicarbazide derivatives as bacterial type IIA topoisomerases inhibitors | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV
Ji-Young Park, Jin-A Ko, Dae Wook Kim, Young Min Kim, Hyung-Jun Kwon, Hyung Jae Jeong, Cha Young Kim, Ki Hun Park, Woo Song Lee & Young Bae Ryu
Pages: 23-30
Published online: 16 Feb 2015
AbstractforChalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV | Full Text | References | PDF (745.5 KB) | Supplemental
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Article
Kinetic and in silico studies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II
Ramin Ekhteiari Salmas, Mert Mestanoglu, Serdar Durdagi, Murat Sentürk, A. Afşin Kaya & Elif Çelenk Kaya
Pages: 31-37
Published online: 13 Feb 2015
AbstractforKinetic and in silico studies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II | Full Text | References | PDF (1.8 MB)
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Article
Searching for anthranilic acid-based thumb pocket 2 HCV NS5B polymerase inhibitors through a combination of molecular docking, 3D-QSAR and virtual screening
Eleni Vrontaki, Georgia Melagraki, Thomas Mavromoustakos & Antreas Afantitis
Pages: 38-52
Published online: 10 Jun 2015
AbstractforSearching for anthranilic acid-based thumb pocket 2 HCV NS5B polymerase inhibitors through a combination of molecular docking, 3D-QSAR and virtual screening | Full Text | References | PDF (1.8 MB)
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Article
Biological activity of pyrazole and imidazole-dehydroepiandrosterone derivatives on the activity of 17β-hydroxysteroid dehydrogenase
Marisa Cabeza, Alejandro Posada, Araceli Sánchez-Márquez, Yvonne Heuze, Isabel Moreno, Juan Soriano, Mariana Garrido, Francisco Cortés & Eugene Bratoeff
Pages: 53-62
Published online: 18 Feb 2015
AbstractforBiological activity of pyrazole and imidazole-dehydroepiandrosterone derivatives on the activity of 17β-hydroxysteroid dehydrogenase | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd
Jude C. Chukwujekwu, Kannan R. R. Rengasamy, Carmen A. de Kock, Peter J. Smith, Lenka Poštová Slavětínská & Johannes van Staden
Pages: 63-66
Published online: 19 Feb 2015
AbstractforAlpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd | Full Text | References | PDF (171.1 KB)
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Article
Biological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease
Catherine Koukoulitsa, Caroline Villalonga-Barber, Robert Csonka, Xanthippi Alexi, Georgios Leonis, Dimitris Dellis, Elizabeth Hamelink, Oscar Belda, Barry R. Steele, Maria Micha-Screttas, Michael N. Alexis, Manthos G. Papadopoulos & Thomas Mavromoustakos
Pages: 67-77
Published online: 06 Jul 2015
AbstractforBiological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease | Full Text | References | PDF (2 MB)
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Article
Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues
Ibrahim A. Al-Suwaidan, Alaa A.-M. Abdel-Aziz, Taghreed Z. Shawer, Rezk R. Ayyad, Amer M. Alanazi, Ahmad M. El-Morsy, Menshawy A. Mohamed, Naglaa I. Abdel-Aziz, Magda A.-A. El-Sayed & Adel S. El-Azab
Pages: 78-89
Published online: 27 Mar 2015
AbstractforSynthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, β-lactamase enzyme inhibition studies
Ferah Cömert Önder, Mehmet Ay, Sümeyye Aydoğan Türkoğlu, Feray Tura Köçkar & Ayhan Çelik
Pages: 90-98
Published online: 16 Feb 2015
AbstractforAntiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, β-lactamase enzyme inhibition studies | Full Text | References | PDF (701.9 KB) | Supplemental
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Article
Hypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats
Kusal K. Das, Nima Razzaghi-Asl, Swati N. Tikare, Roberto Di Santo, Roberta Costi, Antonella Messore, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Jameel G. Jargar, Salim A. Dhundasi & Luciano Saso
Pages: 99-105
Published online: 16 Feb 2015
AbstractforHypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats | Full Text | References | PDF (423.8 KB)
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Article
Stability study of Prulifloxacin and Ulifloxacin in human plasma by HPLC–DAD
Marcello Locatelli, Roberta Cifelli, Giuseppe Carlucci & Annalisa Romagnoli
Pages: 106-111
Published online: 16 Feb 2015
AbstractforStability study of Prulifloxacin and Ulifloxacin in human plasma by HPLC–DAD | Full Text | References | PDF (364.4 KB)
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Article
In silico investigation of PARP-1 catalytic domains in holo and apo states for the design of high-affinity PARP-1 inhibitors
Ramin Ekhteiari Salmas, Ayhan Unlu, Mine Yurtsever, Sergei Y. Noskov & Serdar Durdagi
Pages: 112-120
Published online: 17 Jun 2015
AbstractforIn silico investigation of PARP-1 catalytic domains in holo and apo states for the design of high-affinity PARP-1 inhibitors | Full Text | References | PDF (2.9 MB) | Supplemental
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Article
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
M. Orhan Puskullu, Hanif Shirinzadeh, Merve Nenni, Hande Gurer-Orhan & Sibel Suzen
Pages: 121-125
Published online: 05 May 2015
AbstractforSynthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues | Full Text | References | PDF (389.2 KB)
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Article
(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicans enzymatic repression and cytotoxicity evaluation, Part 2
Pedro Henrique de Azambuja Carvalho, Auri Rocha Duval, Fabio Renato Manzolli Leite, Fernanda Nedel, Wilson Cunico & Rafael Guerra Lund
Pages: 126-131
Published online: 25 Mar 2015
Abstractfor(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicans enzymatic repression and cytotoxicity evaluation, Part 2 | Full Text | References | PDF (367 KB)
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Article
Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiaeβ-carbonic anhydrase
Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava & Claudiu T. Supuran
Pages: 132-136
Published online: 11 Feb 2015
AbstractforDithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiaeβ-carbonic anhydrase | Full Text | References | PDF (335.2 KB)
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Article
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors
Carlotta Granchi, Flavio Rizzolio, Vittorio Bordoni, Isabella Caligiuri, Clementina Manera, Marco Macchia, Filippo Minutolo, Adriano Martinelli, Antonio Giordano & Tiziano Tuccinardi
Pages: 137-146
Published online: 11 Feb 2015
Abstractfor4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors | Full Text | References | PDF (1 MB)
  • 2003 Views
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Article
Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities
Halise Inci Gul, Mehtap Tugrak & Hiroshi Sakagami
Pages: 147-151
Published online: 20 Feb 2015
AbstractforSynthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities | Full Text | References | PDF (148.4 KB)
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Article
The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives
Parham Taslimi, Ilhami Gulcin, Bunyamin Ozgeris, Suleyman Goksu, Ferhan Tumer, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 152-157
Published online: 20 Feb 2015
AbstractforThe human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives | Full Text | References | PDF (201.6 KB)
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Short Communication

Rapid Communication
Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies
Ahmed Elkamhawy, Jung-eun Park, Nam-Chul Cho, Taebo Sim, Ae Nim Pae & Eun Joo Roh
Pages: 158-166
Published online: 25 Mar 2015
AbstractforDiscovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2004 Views
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Rapid Communication
Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase
Desiree E. Mendes, Annie Wong-On-Wing & Clifford E. Berkman
Pages: 167-171
Published online: 27 Mar 2015
AbstractforPhosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase | Full Text | References | PDF (1.6 MB) | Supplemental
  • 672 Views
  • 3 CrossRef citations
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