Figures & data
Table 1. Yield of synthesis of nitroalkenes A1–A7 and their melting points.
Table 2. The antimicrobial activity data expressed as MIC (MBC or MFC) [µg/ml] against the reference strains of microorganisms for compounds A1–A7.
Table 3. The antimicrobial activity data expressed as MBC/MIC and MFC/MIC against the reference strains of microorganisms for compounds A1–A7.
Scheme 1. Synthetic pathway leading to (E)-2-aryl-1-cyano-1-nitroethenes (A2–A7).
Figure 1. Cytotoxicity of compounds A1–A7 (a–g) against cultured HepG2 cells. HepG2 cells were treated with increasing concentrations of the compounds of interest (A1–A7, a–g) or vehicle (DMSO, 0.1%) for 24 h. Cell viability was assessed using MTS assay. Mean absorbance value for DMSO-treated cells was set to 1. The data are expressed as mean ± SD from three independent experiments carried out in sextuplicates. Obtained IC50 values are listed in .
Figure 2. Cytotoxicity of compounds A1–A7 (a–g) against cultured HaCaT cells. HaCaT cells were treated with increasing concentrations of the compounds of interest (A1–A7, a–g) or vehicle (DMSO, 0.1%) for 24 h. Cell viability was assessed using MTS assay. Mean absorbance value for DMSO-treated cells was set to 1. The data are expressed as mean ± SD from three independent experiments carried out in sextuplicates. Obtained IC50 values are listed in .
