Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 6 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 6 (2016)

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Review Article

Review
Tumor metabolism, cancer cell transporters, and microenvironmental resistance
Khalid O. Alfarouk
Pages: 859-866
Published online: 10 Feb 2016
AbstractforTumor metabolism, cancer cell transporters, and microenvironmental resistance | Full Text | References | PDF (683.4 KB)
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Review
Advances in plant-based inhibitors of P-glycoprotein
Jun Yu, Peng Zhou, James Asenso, Xiao-Dan Yang, Chun Wang & Wei Wei
Pages: 867-881
Published online: 02 Mar 2016
AbstractforAdvances in plant-based inhibitors of P-glycoprotein | Full Text | References | PDF (1 MB)
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Review
A nonmainstream approach against cancer
Stefano Fais
Pages: 882-889
Published online: 14 Mar 2016
AbstractforA nonmainstream approach against cancer | Full Text | References | PDF (195.8 KB)
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Review
A review of the effects of some endocrinological factors on respiratory mechanics
Alessandro Rubini, Alessandro Frigo & Emanuele Luigi Carniel
Pages: 890-893
Published online: 22 Mar 2016
AbstractforA review of the effects of some endocrinological factors on respiratory mechanics | Full Text | References | PDF (186 KB)
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Research Article

Article
Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors
Lorenzo Di Cesare Mannelli, Laura Micheli, Fabrizio Carta, Andrea Cozzi, Carla Ghelardini & Claudiu T. Supuran
Pages: 894-899
Published online: 26 Nov 2015
AbstractforCarbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors | Full Text | References | PDF (400.7 KB)
  • 1915 Views
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Article
Novel synthesis scheme and in vitro antimicrobial evaluation of a panel of (E)-2-aryl-1-cyano-1-nitroethenes
Anna Boguszewska-Czubara, Agnieszka Lapczuk-Krygier, Konrad Rykala, Anna Biernasiuk, Artur Wnorowski, Lukasz Popiolek, Agata Maziarka, Anna Hordyjewska & Radomir Jasiński
Pages: 900-907
Published online: 30 Jul 2015
AbstractforNovel synthesis scheme and in vitro antimicrobial evaluation of a panel of (E)-2-aryl-1-cyano-1-nitroethenes | Full Text | References | PDF (495.6 KB)
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Article
Novel dehydroepiandrosterone benzimidazolyl derivatives as 5α-reductase isozymes inhibitors
Yazmín Arellano, Eugene Bratoeff, Tania Segura, Maria Eugenia Mendoza, Araceli Sánchez-Márquez, Yesica Medina, Yvonne Heuze, Juan Soriano & Marisa Cabeza
Pages: 908-914
Published online: 23 Sep 2015
AbstractforNovel dehydroepiandrosterone benzimidazolyl derivatives as 5α-reductase isozymes inhibitors | Full Text | References | PDF (647.6 KB)
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Article
Antiproliferative and antibacterial activity of some glutarimide derivatives
Jelena B. Popović-Djordjević, Anita S. Klaus, Željko S. Žižak, Ivana Z. Matić & Branko J. Drakulić
Pages: 915-923
Published online: 06 Aug 2015
AbstractforAntiproliferative and antibacterial activity of some glutarimide derivatives | Full Text | References | PDF (579.3 KB) | Supplemental
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Article
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione
Grazia Luisi, Adriano Mollica, Simone Carradori, Alessia Lenoci, Anastasia De Luca & Anna Maria Caccuri
Pages: 924-930
Published online: 02 Sep 2015
AbstractforNitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione | Full Text | References | PDF (418.5 KB)
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Article
Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase
Paulina Kosikowska, Marta Bochno, Katarzyna Macegoniuk, Giuseppe Forlani, Paweł Kafarski & Łukasz Berlicki
Pages: 931-938
Published online: 03 Aug 2015
AbstractforBisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes
Koray Oktay, Leyla Polat Köse, Kıvılcım Şendil, Mehmet Serdar Gültekin, İlhami Gülçin & Claudiu T. Supuran
Pages: 939-945
Published online: 24 Aug 2015
AbstractforThe synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes | Full Text | References | PDF (452.2 KB) | Supplemental
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Article
Multimeric xanthates as carbonic anhydrase inhibitors
Marta Abellán-Flos, Muhammet Tanç, Claudiu T. Supuran & Stéphane P. Vincent
Pages: 946-952
Published online: 03 Aug 2015
AbstractforMultimeric xanthates as carbonic anhydrase inhibitors | Full Text | References | PDF (900.1 KB) | Supplemental
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Article
Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine
Adriano Mollica, Sako Mirzaie, Roberto Costante, Simone Carradori, Giorgia Macedonio, Azzurra Stefanucci, Szabolcs Dvoracsko & Ettore Novellino
Pages: 953-963
Published online: 24 Aug 2015
AbstractforExploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine | Full Text | References | PDF (3.3 MB) | Supplemental
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Article
Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease
Dayanne da Rocha de Menezes, Claudia Magalhães Calvet, Giseli Capaci Rodrigues, Mirian Claudia de Souza Pereira, Igor Rodrigues Almeida, Alcino Palermo de Aguiar, Claudiu T. Supuran & Alane Beatriz Vermelho
Pages: 964-973
Published online: 31 Aug 2015
AbstractforHydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease | Full Text | References | PDF (1.5 MB)
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Article
Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
Grzegorz Cholewinski, Dorota Iwaszkiewicz-Grzes, Piotr Trzonkowski & Krystyna Dzierzbicka
Pages: 974-982
Published online: 24 Aug 2015
AbstractforSynthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents | Full Text | References | PDF (399.1 KB) | Supplemental
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Article
GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen
Ramazan Ceylan, Gokhan Zengin, Sengul Uysal, Veli Ilhan, Abdurrahman Aktumsek, Ali Kandemir & Farooq Anwar
Pages: 983-990
Published online: 31 Aug 2015
AbstractforGC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen | Full Text | References | PDF (206.1 KB)
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Article
Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives
Belma Zengin Kurt, Fatih Sönmez, Çiğdem Bilen, Adem Ergun, Nahit Gençer, Oktay Arslan & Mustafa Kucukislamoglu
Pages: 991-998
Published online: 24 Aug 2015
AbstractforSynthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives | Full Text | References | PDF (986.9 KB)
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Article
Effects of dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], on cell viability and gene expression of common human cancer drug targets in a melanoma cell line
Lejla Pojskic, Sanin Haveric, Naida Lojo-Kadric, Maida Hadzic, Anja Haveric, Zoran Galic, Borivoj Galic, Daniela Vullo, Claudiu T. Supuran & Mladen Milos
Pages: 999-1004
Published online: 24 Aug 2015
AbstractforEffects of dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], on cell viability and gene expression of common human cancer drug targets in a melanoma cell line | Full Text | References | PDF (649.3 KB)
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Article
Synthesis of novel sulfonamide analogs containing sulfamerazine/sulfaguanidine and their biological activities
Burak Aday, Pınar Sola, Ferdağ Çolak & Muharrem Kaya
Pages: 1005-1010
Published online: 31 Aug 2015
AbstractforSynthesis of novel sulfonamide analogs containing sulfamerazine/sulfaguanidine and their biological activities | Full Text | References | PDF (220.4 KB) | Supplemental
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Article
Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach
Giulio Poli, Arianna Gelain, Federica Porta, Akira Asai, Adriano Martinelli & Tiziano Tuccinardi
Pages: 1011-1017
Published online: 24 Aug 2015
AbstractforIdentification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach | Full Text | References | PDF (908 KB) | Supplemental
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Article
NSAIDs do not require the presence of a carboxylic acid to exert their anti-inflammatory effect – why do we keep using it?
Nasir Ullah, Zhangjian Huang, Forough Sanaee, Alexandra Rodriguez-Dimitrescu, Fahad Aldawsari, Fakhreddin Jamali, Atul Bhardwaj, Nazar Ul Islam & Carlos A. Velázquez-Martínez
Pages: 1018-1028
Published online: 24 Sep 2015
AbstractforNSAIDs do not require the presence of a carboxylic acid to exert their anti-inflammatory effect – why do we keep using it? | Full Text | References | PDF (1.3 MB)
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Article
Exploring the inhibitory activity of Withaferin-A against Pteridine reductase-1 of L. donovani
Sambamurthy Chandrasekaran, Jalaja Veronica, Ravi Kumar Gundampati, Shyam Sundar & Radheshyam Maurya
Pages: 1029-1037
Published online: 25 Sep 2015
AbstractforExploring the inhibitory activity of Withaferin-A against Pteridine reductase-1 of L. donovani | Full Text | References | PDF (1.4 MB)
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Article
Synthesis and anticonvulsant activity of new N-mannich bases derived from benzhydryl- and isopropyl-pyrrolidine-2,5-dione
Sabina Rybka, Jolanta Obniska, Anna Rapacz, Barbara Filipek & Paweł Żmudzki
Pages: 1038-1047
Published online: 25 Sep 2015
AbstractforSynthesis and anticonvulsant activity of new N-mannich bases derived from benzhydryl- and isopropyl-pyrrolidine-2,5-dione | Full Text | References | PDF (710.6 KB)
  • 951 Views
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Article
Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity
Grażyna Chłoń-Rzepa, Adam Bucki, Marcin Kołaczkowski, Anna Partyka, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Andrzej J. Bojarski, Justyna Kalinowska-Tłuścik, Grzegorz Kazek, Barbara Mordyl, Monika Głuch-Lutwin & Anna Wesołowska
Pages: 1048-1062
Published online: 25 Sep 2015
AbstractforArylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity | Full Text | References | PDF (1 MB) | Supplemental
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Article
Dual effect of nitric oxide on phenoloxidase-mediated melanization
Urikhan Sanzhaeva, Yana Vorontsova, Yuriy Glazachev & Irina Slepneva
Pages: 1063-1068
Published online: 25 Sep 2015
AbstractforDual effect of nitric oxide on phenoloxidase-mediated melanization | Full Text | References | PDF (522.2 KB)
  • 876 Views
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Article
Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase
Elaine da Conceição Petronilho, Magdalena do Nascimento Rennó, Newton Gonçalves Castro, Fernanda Motta R. da Silva, Angelo da Cunha Pinto & José Daniel Figueroa-Villar
Pages: 1069-1078
Published online: 11 Nov 2015
AbstractforDesign, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase | Full Text | References | PDF (1,014.8 KB) | Supplemental
  • 1716 Views
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Article
Synthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agents
Wissam H. Faour, Mohamed Mroueh, Costatantine F. Daher, Rasha Y. Elbayaa, Hanan M. Ragab, Asser I. Ghoneim, Ahmed I. El-mallah & Hayam M. A. Ashour
Pages: 1079-1094
Published online: 20 Oct 2015
AbstractforSynthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agents | Full Text | References | PDF (533.1 KB)
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Original Article

Article
The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII
İlhami Gülçin, Andrea Scozzafava, Claudiu T. Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan & Saleh Alwasel
Pages: 1095-1101
Published online: 09 Oct 2015
AbstractforThe effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII | Full Text | References | PDF (238.1 KB)
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Article
Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action
Jorge R. A. Diaz, Gerardo Enrique Camí, Malva Liu-González, Daniel R. Vega, Daniela Vullo, Américo Juárez, José C. Pedregosa & Claudiu T. Supuran
Pages: 1102-1110
Published online: 26 Oct 2015
AbstractforSalts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action | Full Text | References | PDF (878.3 KB) | Supplemental
  • 1404 Views
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Research Article

Article
Cloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13
Ayşenur Eminoğlu, Daniela Vullo, Aycan Aşık, Dilşat Nigar Çolak, Claudiu T. Supuran, Sabriye Çanakçı & Ali Osman Beldüz
Pages: 1111-1118
Published online: 26 Oct 2015
AbstractforCloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13 | Full Text | References | PDF (2 MB)
  • 1614 Views
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Article
Interaction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp
Furkan Orhan, Murat Şentürk & Claudiu T. Supuran
Pages: 1119-1123
Published online: 03 Nov 2015
AbstractforInteraction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp | Full Text | References | PDF (304.4 KB)
  • 790 Views
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Article
The biological effects of vanadyl curcumin and vanadyl diacetylcurcumin complexes: the effect on structure, function and oxidative stability of the peroxidase enzyme, antibacterial activity and cytotoxic effect
Akram Hamidi, Leila Hassani, Fakhrossadat Mohammadi, Parisa Jahangoshayi & Khosro Mohammadi
Pages: 1124-1131
Published online: 30 Oct 2015
AbstractforThe biological effects of vanadyl curcumin and vanadyl diacetylcurcumin complexes: the effect on structure, function and oxidative stability of the peroxidase enzyme, antibacterial activity and cytotoxic effect | Full Text | References | PDF (708.4 KB) | Supplemental
  • 1208 Views
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Article
Synthesis and anticancer and lipophilic properties of 10-dialkylaminobutynyl derivatives of 1,8- and 2,7-diazaphenothiazines
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń & Dariusz Kuśmierz
Pages: 1132-1138
Published online: 02 Nov 2015
AbstractforSynthesis and anticancer and lipophilic properties of 10-dialkylaminobutynyl derivatives of 1,8- and 2,7-diazaphenothiazines | Full Text | References | PDF (291.2 KB)
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Article
Antitumor activity of amidino-substituted benzimidazole and benzimidazo[1,2-a]quinoline derivatives tested in 2D and 3D cell culture systems
Karmen Brajša, Ines Vujasinović, Dubravko Jelić, Marija Trzun, Ivo Zlatar, Grace Karminski-Zamola & Marijana Hranjec
Pages: 1139-1145
Published online: 27 Oct 2015
AbstractforAntitumor activity of amidino-substituted benzimidazole and benzimidazo[1,2-a]quinoline derivatives tested in 2D and 3D cell culture systems | Full Text | References | PDF (283.8 KB)
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Article
Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads
Mikhail Krasavin, Prashant Mujumdar, Vladislav Parchinsky, Tatiana Vinogradova, Olga Manicheva & Marine Dogonadze
Pages: 1146-1155
Published online: 02 Nov 2015
AbstractforLibrary of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads | Full Text | References | PDF (387.2 KB) | Supplemental
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Article
A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target
Sonia Del Prete, Viviana De Luca, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso
Pages: 1156-1161
Published online: 02 Nov 2015
AbstractforA new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target | Full Text | References | PDF (458.6 KB)
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Article
Rapid and direct spectrophotometric method for kinetics studies and routine assay of peroxidase based on aniline diazo substrates
Fatemeh Mirazizi, Azita Bahrami, Kamahldin Haghbeen, Hossein Shahbani Zahiri, Mehdi Bakavoli & Raymond L. Legge
Pages: 1162-1169
Published online: 02 Nov 2015
AbstractforRapid and direct spectrophotometric method for kinetics studies and routine assay of peroxidase based on aniline diazo substrates | Full Text | References | PDF (416.3 KB)
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Article
Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2
Araceli Sánchez-Márquez, Yazmín Arellano, Eugene Bratoeff, Yvonne Heuze, Karen Córdova, Gladys Nieves, Juan Soriano & Marisa Cabeza
Pages: 1170-1176
Published online: 02 Nov 2015
AbstractforSynthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2 | Full Text | References | PDF (963.2 KB) | Supplemental
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Article
Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives
Leyla Yurttaş, Usama Abu Mohsen, Yeşim Ozkan, Simla Cobanoglu, Serkan Levent & Zafer Asım Kaplancikli
Pages: 1177-1183
Published online: 18 Nov 2015
AbstractforSynthesis and biological evaluation of some dibenzofuran-piperazine derivatives | Full Text | References | PDF (297.4 KB) | Supplemental
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Article
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors
Roberta Ettari, Santo Previti, Sandro Cosconati, Jochen Kesselring, Tanja Schirmeister, Silvana Grasso & Maria Zappalà
Pages: 1184-1191
Published online: 16 Nov 2015
AbstractforSynthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors | Full Text | References | PDF (508.6 KB)
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Article
Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects
Afsun Sujayev, Leyla Polat Kose, Emin Garibov, İlhami Gülçin, Vagif Farzaliev, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 1192-1197
Published online: 19 Nov 2015
AbstractforSynthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects | Full Text | References | PDF (226.1 KB)
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Article
Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties
F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran
Pages: 1198-1202
Published online: 19 Nov 2015
AbstractforSynthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties | Full Text | References | PDF (250.3 KB)
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Article
Calcium-independent phospholipases A2 in murine osteoblastic cells and their inhibition by bromoenol lactone: impact on arachidonate dynamics and prostaglandin synthesis
Hans Jörg Leis & Werner Windischhofer
Pages: 1203-1213
Published online: 26 Nov 2015
AbstractforCalcium-independent phospholipases A2 in murine osteoblastic cells and their inhibition by bromoenol lactone: impact on arachidonate dynamics and prostaglandin synthesis | Full Text | References | PDF (570 KB)
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Article
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Serdar Durdagi, Neslihan Korkmaz, Semra Işık, Daniela Vullo, Demet Astley, Deniz Ekinci, Ramin E. Salmas, Murat Senturk & Claudiu T. Supuran
Pages: 1214-1220
Published online: 04 Dec 2015
AbstractforKinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds | Full Text | References | PDF (1.7 MB)
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Article
Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives
F. Zehra Küçükbay, Nesrin Buğday, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran
Pages: 1221-1225
Published online: 24 Nov 2015
AbstractforSynthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives | Full Text | References | PDF (263.7 KB)
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Article
7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII
Alessio Nocentini, Mariangela Ceruso, Fabrizio Carta & Claudiu T. Supuran
Pages: 1226-1233
Published online: 18 Dec 2015
Abstractfor7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII | Full Text | References | PDF (1.4 MB)
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Article
Inhibitory effects of some phenolic compounds on the activities of carbonic anhydrase: from in vivo to ex vivo
Zübeyir Huyut, Şükrü Beydemir & İlhami Gülçin
Pages: 1234-1240
Published online: 15 Dec 2015
AbstractforInhibitory effects of some phenolic compounds on the activities of carbonic anhydrase: from in vivo to ex vivo | Full Text | References | PDF (376.3 KB)
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Article
Thermotolerant alkaline protease enzyme from Bacillus licheniformis A10: purification, characterization, effects of surfactants and organic solvents
Bahar Yilmaz, Mustafa Ozkan Baltaci, Melda Sisecioglu & Ahmet Adiguzel
Pages: 1241-1247
Published online: 04 Dec 2015
AbstractforThermotolerant alkaline protease enzyme from Bacillus licheniformis A10: purification, characterization, effects of surfactants and organic solvents | Full Text | References | PDF (383.6 KB)
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Article
The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates
Leyla Polat Kose, İlhami Gulcin, Alper Yıldırım, Ufuk Atmaca, Murat Çelik, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 1248-1253
Published online: 18 Dec 2015
AbstractforThe human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates | Full Text | References | PDF (249.6 KB)
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Article
New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences
Claudiu T. Supuran & Clemente Capasso
Pages: 1254-1260
Published online: 28 Jun 2016
AbstractforNew light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences | Full Text | References | PDF (918.7 KB)
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Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model
Alexandre C. Serquiz, Richele J. A. Machado, Raphael P. Serquiz, Vanessa C. O. Lima, Fabiana Maria C. de Carvalho, Marcella A. A. Carneiro, Bruna L. L. Maciel, Adriana F. Uchôa, Elizeu A. Santos & Ana H. A. Morais
Pages: 1261-1269
Published online: 29 Feb 2016
AbstractforSupplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model | Full Text | References | PDF (637.6 KB)
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Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress
Francesco Menichini, Rosa Tundis, Monica R. Loizzo, Marco Bonesi, Danila D’Angelo, Pietro Lombardi & Vincenzo Mastellone
Pages: 1270-1276
Published online: 08 Dec 2015
AbstractforCitrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress | Full Text | References | PDF (310.7 KB)
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Design, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities
Abderrahim Ben Saïd, Anis Romdhane, Nicolas Elie, David Touboul, Hichem Ben Jannet & Jalloul Bouajila
Pages: 1277-1285
Published online: 18 Dec 2015
AbstractforDesign, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities | Full Text | References | PDF (446.7 KB)
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Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
Ahmed Malki, Hayam M. A. Ashour, Rasha Y. Elbayaa, Doaa A. E. Issa, Hassan A. Aziz & Xiaozhuo Chen
Pages: 1286-1299
Published online: 18 Dec 2015
AbstractforNovel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells | Full Text | References | PDF (1.4 MB)
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Article
Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II
Soner Kılıcaslan, Mustafa Arslan, Zeynep Ruya, Çigdem Bilen, Adem Ergün, Nahit Gençer & Oktay Arslan
Pages: 1300-1305
Published online: 08 Jan 2016
AbstractforSynthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II | Full Text | References | PDF (213.7 KB)
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Article
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds
Anthi Petrou, Athina Geronikaki, Emine Terzi, Ozen Ozensoy Guler, Tiziano Tuccinardi & Claudiu T. Supuran
Pages: 1306-1311
Published online: 08 Jan 2016
AbstractforInhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds | Full Text | References | PDF (738.5 KB)
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Article
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
Hanif Shirinzadeh, Elif Ince, Andrew D. Westwell, Hande Gurer-Orhan & Sibel Suzen
Pages: 1312-1321
Published online: 08 Jan 2016
AbstractforNovel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities | Full Text | References | PDF (850 KB)
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Article
In vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes
Yetkin Gök, Senem Akkoç, Hülya Erdoğan & Sevil Albayrak
Pages: 1322-1327
Published online: 08 Jan 2016
AbstractforIn vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes | Full Text | References | PDF (247.2 KB)
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Article
Two legume defense proteins suppress the mobility of nasopharyngeal carcinoma cells
Xiuli Dan & Tzi Bun Ng
Pages: 1328-1334
Published online: 10 Jan 2016
AbstractforTwo legume defense proteins suppress the mobility of nasopharyngeal carcinoma cells | Full Text | References | PDF (713.1 KB)
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Article
Purification and characterization of dihydropyrimidine dehydrogenase enzyme from sheep liver and determination of the effects of some anaesthetic and antidepressant drugs on the enzyme activity
Yasemin Camadan, Hasan Özdemir & İlhami Gulcin
Pages: 1335-1341
Published online: 13 Jan 2016
AbstractforPurification and characterization of dihydropyrimidine dehydrogenase enzyme from sheep liver and determination of the effects of some anaesthetic and antidepressant drugs on the enzyme activity | Full Text | References | PDF (327.2 KB)
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Article
Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics
Sevki Adem & Mehmet Ciftci
Pages: 1342-1348
Published online: 12 Jan 2016
AbstractforPurification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics | Full Text | References | PDF (680.4 KB)
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Article
Is there a relation between genetic susceptibility with cancer? A study about paraoxanase (PON1) enzyme activity in breast cancer cases
Mustafa Oğuzhan Kaya, Selma Sinan, Özen Özensoy Güler & Oktay Arslan
Pages: 1349-1355
Published online: 14 Jan 2016
AbstractforIs there a relation between genetic susceptibility with cancer? A study about paraoxanase (PON1) enzyme activity in breast cancer cases | Full Text | References | PDF (633.7 KB)
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Article
Synthesis of novel sulfonamides under mild conditions with effective inhibitory activity against the carbonic anhydrase isoforms I and II
Erhan Başar, Ekrem Tunca, Metin Bülbül & Muharrem Kaya
Pages: 1356-1361
Published online: 27 Jan 2016
AbstractforSynthesis of novel sulfonamides under mild conditions with effective inhibitory activity against the carbonic anhydrase isoforms I and II | Full Text | References | PDF (223.5 KB) | Supplemental
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Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1
Katarzyna A. Piechowicz, Eric C. Truong, Kashif M. Javed, Rachelle R. Chaney, Johnny Y. Wu, Puay W. Phuan, Alan S. Verkman & Marc O. Anderson
Pages: 1362-1368
Published online: 22 Jan 2016
AbstractforSynthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1 | Full Text | References | PDF (380.6 KB) | Supplemental
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Article
NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives
Mostafa M. Ghorab, Mansour S. Alsaid, Marwa G. El-Gazzar, Maureen Higgins, Albena T. Dinkova-Kostova & Abdelaaty A. Shahat
Pages: 1369-1374
Published online: 21 Jan 2016
AbstractforNAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives | Full Text | References | PDF (489.7 KB)
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Article
Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol
Halise Inci Gul, Cem Yamali, Asiye Tugce Yasa, Elif Unluer, Hiroshi Sakagami, Muhammet Tanc & Claudiu T. Supuran
Pages: 1375-1380
Published online: 05 Feb 2016
AbstractforCarbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol | Full Text | References | PDF (285.4 KB)
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Article
Ectopic expression of a tobacco vacuolar invertase inhibitor in guard cells confers drought tolerance in Arabidopsis
Su-Fen Chen, Ke Liang, Dong-Mei Yin, Di-An Ni, Zhi-Guo Zhang & Yong-Ling Ruan
Pages: 1381-1385
Published online: 22 Feb 2016
AbstractforEctopic expression of a tobacco vacuolar invertase inhibitor in guard cells confers drought tolerance in Arabidopsis | Full Text | References | PDF (456.2 KB) | Supplemental
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Article
Some coumarins and benzoxazinones as potent paraoxonase 1 inhibitors
Mert Olgun Karataş, Harun Uslu, Bülent Alıcı, Başak Gökçe, Nahit Gencer & Oktay Arslan
Pages: 1386-1391
Published online: 17 Feb 2016
AbstractforSome coumarins and benzoxazinones as potent paraoxonase 1 inhibitors | Full Text | References | PDF (585.9 KB)
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Article
Ultrasonic synthesis of tyramine derivatives as novel inhibitors of α-glucosidase in vitro
Hina Siddiqui, Muhammad Arslan Bashir, Kulsoom Javaid, Arsalan Nizamani, Huma Bano, Sammer Yousuf, Atta-ur Rahman & M. Iqbal Choudhary
Pages: 1392-1403
Published online: 25 Feb 2016
AbstractforUltrasonic synthesis of tyramine derivatives as novel inhibitors of α-glucosidase in vitro | Full Text | References | PDF (2 MB)
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Article
Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold
Mikhail Krasavin, Alexey Lukin, Nikolay Zhurilo, Alexey Kovalenko, Ihor Zahanich & Sergey Zozulya
Pages: 1404-1410
Published online: 22 Feb 2016
AbstractforNovel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Molecular processes in the streptokinase thrombolytic therapy
Cristian Capitanescu, Anca Monica Macovei Oprescu, Dan Ionita, Gabi Valeriu Dinca, Claudiu Turculet, Gheorghe Manole & Radu Alexandru Macovei
Pages: 1411-1414
Published online: 12 Feb 2016
AbstractforMolecular processes in the streptokinase thrombolytic therapy | Full Text | References | PDF (214.4 KB)
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Article
Design and synthesis of pyridazinone-substituted benzenesulphonylurea derivatives as anti-hyperglycaemic agents and inhibitors of aldose reductase – an enzyme embroiled in diabetic complications
Raed Yaseen, H. Pushpalatha, G. Bhanuprakash Reddy, Ameer Ismael, Ayad Ahmed, Alhamza Dheyaa, Syed Ovais, Pooja Rathore, Mohammed Samim, Mymoona Akthar, Kalicharan Sharma, Syed Shafi, Surender Singh & Kalim Javed
Pages: 1415-1427
Published online: 16 Feb 2016
AbstractforDesign and synthesis of pyridazinone-substituted benzenesulphonylurea derivatives as anti-hyperglycaemic agents and inhibitors of aldose reductase – an enzyme embroiled in diabetic complications | Full Text | References | PDF (1.4 MB)
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Article
Molecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery
N. S. Hari Narayana Moorthy, Sergio F. Sousa, Maria J. Ramos & Pedro A. Fernandes
Pages: 1428-1442
Published online: 18 Feb 2016
AbstractforMolecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery | Full Text | References | PDF (24.2 MB)
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Article
Pred-binding: large-scale protein–ligand binding affinity prediction
Piar Ali Shar, Weiyang Tao, Shuo Gao, Chao Huang, Bohui Li, Wenjuan Zhang, Mohamed Shahen, Chunli Zheng, Yaofei Bai & Yonghua Wang
Pages: 1443-1450
Published online: 18 Feb 2016
AbstractforPred-binding: large-scale protein–ligand binding affinity prediction | Full Text | References | PDF (1.9 MB) | Supplemental
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Article
Niacin esters of chalcones with tumor-selective properties
Atulya K. Panda, Umashankar Das, Praveen K. Roayapalley, Hiroshi Sakagami, Masami Kawase, Jan Balzarini, Erik De Clercq & Jonathan R. Dimmock
Pages: 1451-1456
Published online: 02 Jun 2016
AbstractforNiacin esters of chalcones with tumor-selective properties | Full Text | References | PDF (239.2 KB)
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Synthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivatives
Heng Song, Yinxing Sun, Guanglin Xu, Bingbo Hou & Guizhen Ao
Pages: 1457-1463
Published online: 21 Feb 2016
AbstractforSynthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivatives | Full Text | References | PDF (490.1 KB) | Supplemental
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Article
Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation
Gisele S. da Silva, Micheli Figueiró, Claudio F. Tormena, Fernando Coelho & Wanda P Almeida
Pages: 1464-1470
Published online: 01 Mar 2016
AbstractforEffects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation | Full Text | References | PDF (697 KB) | Supplemental
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Comparative assay of Vipera ammodytes antivenom potency
Cristian Capitanescu, Anca Monica Macovei Oprescu, Alexandru Supeanu, Bogdan Ioan Coculescu, Victor Strambu, Radu Alexandru Macovei & Gheorghe Manole
Pages: 1471-1475
Published online: 17 Feb 2016
AbstractforComparative assay of Vipera ammodytes antivenom potency | Full Text | References | PDF (265.3 KB)
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Article
Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates
F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran
Pages: 1476-1483
Published online: 21 Feb 2016
AbstractforSynthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates | Full Text | References | PDF (259 KB)
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Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase
Süleyman Yılmaz, Yusuf Akbaba, Bünyamin Özgeriş, Leyla Polat Köse, Süleyman Göksu, İlhami Gülçin, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 1484-1491
Published online: 17 Mar 2016
AbstractforSynthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase | Full Text | References | PDF (381.7 KB)
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Inhibitory effects of Aphanizomenon flos-aquae constituents on human UDP-glucose dehydrogenase activity
Stefano Scoglio, Valeria Lo Curcio, Simona Catalani, Francesco Palma, Serafina Battistelli & Serena Benedetti
Pages: 1492-1497
Published online: 23 Feb 2016
AbstractforInhibitory effects of Aphanizomenon flos-aquae constituents on human UDP-glucose dehydrogenase activity | Full Text | References | PDF (392.5 KB)
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Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
Dilan Ozmen Ozgun, Cem Yamali, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Telat Yanik & Claudiu T. Supuran
Pages: 1498-1501
Published online: 01 Mar 2016
AbstractforInhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase | Full Text | References | PDF (192.7 KB)
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Article
Xylarinase: a novel clot busting enzyme from an endophytic fungus Xylaria curta
Vineet Meshram, Sanjai Saxena & Karan Paul
Pages: 1502-1511
Published online: 31 Mar 2016
AbstractforXylarinase: a novel clot busting enzyme from an endophytic fungus Xylaria curta | Full Text | References | PDF (1.5 MB)
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3,6-Diazaphenothiazines as potential lead molecules – synthesis, characterization and anticancer activity
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Kinga Suwińska, Małgorzata Jeleń & Dariusz Kuśmierz
Pages: 1512-1519
Published online: 07 Mar 2016
Abstractfor3,6-Diazaphenothiazines as potential lead molecules – synthesis, characterization and anticancer activity | Full Text | References | PDF (441 KB) | Supplemental
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Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids
Pramod K. Sharma, Sakshi Balwani, Divya Mathur, Shashwat Malhotra, Brajendra K. Singh, Ashok K. Prasad, Christophe Len, Erik V. Van der Eycken, Balaram Ghosh, Nigel G. J. Richards & Virinder S. Parmar
Pages: 1520-1526
Published online: 05 May 2016
AbstractforSynthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids | Full Text | References | PDF (552.8 KB) | Supplemental
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Article
Benzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity
Yakup Sarı, Senem Akkoç, Yetkin Gök, Vicki Sifniotis, İlknur Özdemir, Selami Günal & Veysel Kayser
Pages: 1527-1530
Published online: 17 Mar 2016
AbstractforBenzimidazolium-based novel silver N-heterocyclic carbene complexes: synthesis, characterisation and in vitro antimicrobial activity | Full Text | References | PDF (235 KB)
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Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase
Afsun Sujayev, Emin Garibov, Parham Taslimi, İlhami Gulçin, Sevinj Gojayeva, Vagif Farzaliyev, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 1531-1539
Published online: 28 Mar 2016
AbstractforSynthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase | Full Text | References | PDF (597.1 KB)
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Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II
Halise Inci Gul, Zehra Yazici, Muhammet Tanc & Claudiu T. Supuran
Pages: 1540-1544
Published online: 17 Mar 2016
AbstractforInhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II | Full Text | References | PDF (196 KB)
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Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore
Khaled R. A. Abdellatif, Mohammed T. Elsaady, Salah A. Abdel-Aziz & Ahmed H. A. Abusabaa
Pages: 1545-1555
Published online: 12 Apr 2016
AbstractforSynthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore | Full Text | References | PDF (1 MB)
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Apparent cooperativity and apparent hyperbolic behavior of enzyme mixtures acting on the same substrate
Mario Cappiello, Francesco Balestri, Roberta Moschini, Antonella Del-Corso & Umberto Mura
Pages: 1556-1559
Published online: 12 Apr 2016
AbstractforApparent cooperativity and apparent hyperbolic behavior of enzyme mixtures acting on the same substrate | Full Text | References | PDF (288.2 KB)
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Purification and characterization of a Cys-Gly hydrolase from the gastropod mollusk, Patella caerulea
Mario Cappiello, Matteo Spinelli, Maurizio Mormino, Giovanni Renzone, Andrea Scaloni, Roberta Moschini, Francesco Balestri, Umberto Mura & Antonella Del-Corso
Pages: 1560-1565
Published online: 22 Mar 2016
AbstractforPurification and characterization of a Cys-Gly hydrolase from the gastropod mollusk, Patella caerulea | Full Text | References | PDF (1.2 MB) | Supplemental
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Design and synthesis of antimicrobial, anticoagulant, and anticholinesterase hybrid molecules from 4-methylumbelliferone
Marwa Zayane, Ameur Rahmouni, Mejda Daami-Remadi, Mohamed Ben Mansour, Anis Romdhane & Hichem Ben Jannet
Pages: 1566-1575
Published online: 01 Apr 2016
AbstractforDesign and synthesis of antimicrobial, anticoagulant, and anticholinesterase hybrid molecules from 4-methylumbelliferone | Full Text | References | PDF (454.6 KB)
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Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures
Krzysztof Z. Łączkowski, Kinga Sałat, Konrad Misiura, Adrian Podkowa & Natalia Malikowska
Pages: 1576-1582
Published online: 06 Apr 2016
AbstractforSynthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures | Full Text | References | PDF (655.1 KB)
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In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and β-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice
Hatice Yildirim, Fatma Bahar Sunay, Selma Sinan & Feray Köçkar
Pages: 1583-1590
Published online: 22 Mar 2016
AbstractforIn vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and β-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice | Full Text | References | PDF (997.4 KB)
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Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization
Max Seidy Saito, André Luiz Lourenço, Luiza Rosaria Sousa Dias, Antônio Carlos Carreira Freitas, Maíra Ingrid Vitorino, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Lúcio Mendes Cabral, Eliane Pedra Dias, Helena Carla Castro & Plínio Cunha Satlher
Pages: 1591-1601
Published online: 22 Mar 2016
AbstractforAntiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization | Full Text | References | PDF (2.6 MB)
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Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities
Mehdi Khoshneviszadeh, Omolbanin Shahraki, Mahsima Khoshneviszadeh, Alireza Foroumadi, Omidreza Firuzi, Najmeh Edraki, Hamid Nadri, Alireza Moradi, Abbas Shafiee & Ramin Miri
Pages: 1602-1611
Published online: 30 Mar 2016
AbstractforStructure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities | Full Text | References | PDF (1.8 MB)
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Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives
Mostafa M. Ghorab, Mansour S. Alsaid, Maureen Higgins, Albena T. Dinkova-Kostova, Abdelaaty A. Shahat, Nehal H. Elghazawy & Reem K. Arafa
Pages: 1612-1618
Published online: 07 Apr 2016
AbstractforSynthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives | Full Text | References | PDF (912.5 KB)
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Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides
Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran
Pages: 1619-1624
Published online: 30 Mar 2016
AbstractforSynthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides | Full Text | References | PDF (238.6 KB)
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Biological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects
Graciela E. Escudero, Nancy Martini, Khalil Jori, Nadir Jori, Nahuel R. Maresca, Carlos H. Laino, Luciana G. Naso, Patricia A.M. Williams & Evelina G. Ferrer
Pages: 1625-1631
Published online: 30 Mar 2016
AbstractforBiological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects | Full Text | References | PDF (431.5 KB)
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Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5
Angela Cirigliano, Alessandro Stirpe, Sergio Menta, Mattia Mori, Domenico Dell’Edera, Elah Pick, Rodolfo Negri, Bruno Botta & Teresa Rinaldi
Pages: 1632-1637
Published online: 30 Mar 2016
AbstractforYeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5 | Full Text | References | PDF (682.3 KB) | Supplemental
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Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates
Ludovica Monti, Azzurra Stefanucci, Stefano Pieretti, Francesca Marzoli, Lorenzo Fidanza, Adriano Mollica, Sako Mirzaie, Simone Carradori, Luciano De Petrocellis, Aniello Schiano Moriello, Sándor Benyhe, Ferenc Zádor, Edina Szűcs, Ferenc Ötvös, Anna I. Erdei, Reza Samavati, Szabolcs Dvorácskó, Csaba Tömböly & Ettore Novellino
Pages: 1638-1647
Published online: 11 Apr 2016
AbstractforEvaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates | Full Text | References | PDF (1.5 MB) | Supplemental
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Simple ITC method for activity and inhibition studies on human salivary α-amylase
Gábor Lehoczki, Kármen Szabó, István Takács, Lili Kandra & Gyöngyi Gyémánt
Pages: 1648-1653
Published online: 06 Apr 2016
AbstractforSimple ITC method for activity and inhibition studies on human salivary α-amylase | Full Text | References | PDF (442.5 KB)
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Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
Betül Kaya, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay & Zafer Asım Kaplancıklı
Pages: 1654-1661
Published online: 30 Mar 2016
AbstractforSynthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents | Full Text | References | PDF (361.2 KB)
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Characterization and inhibition studies of carbonic anhydrase from gill of Russian Sturgeon Fish (Acipenser gueldenstaedtii)
Barbaros Dinçer, Arife Pınar Ekinci, Gülay Akyüz & İlker Zeki Kurtoğlu
Pages: 1662-1665
Published online: 19 Aug 2015
AbstractforCharacterization and inhibition studies of carbonic anhydrase from gill of Russian Sturgeon Fish (Acipenser gueldenstaedtii) | Full Text | References | PDF (258.3 KB)
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Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
Mardia Telep El-Sayed, Roya Zoraghi, Neil Reiner, Sibel Suzen, Knut Ohlsen, Michael Lalk, Nurten Altanlar & Andreas Hilgeroth
Pages: 1666-1671
Published online: 10 Dec 2015
AbstractforNovel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase | Full Text | References | PDF (342.6 KB) | Supplemental
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Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida
Rita Meleddu, Simona Distinto, Angela Corona, Elias Maccioni, Antonella Arridu, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Adriana Sanna & Alessandro De Logu
Pages: 1672-1677
Published online: 08 Jan 2016
AbstractforExploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida | Full Text | References | PDF (326.7 KB)
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The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes
Cem Yamali, Mehtap Tugrak, Halise Inci Gul, Muhammet Tanc & Claudiu T. Supuran
Pages: 1678-1681
Published online: 10 Jan 2016
AbstractforThe inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes | Full Text | References | PDF (245.1 KB)
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Synthesis and in vivo diuretic activity of some new benzothiazole sulfonamides containing quinoxaline ring system
Asif Husain, Diwakar Madhesia, Mohd Rashid, Aftab Ahmad & Shah Alam Khan
Pages: 1682-1689
Published online: 07 Jan 2016
AbstractforSynthesis and in vivo diuretic activity of some new benzothiazole sulfonamides containing quinoxaline ring system | Full Text | References | PDF (1.1 MB)
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A method to determine the mode of binding for GCPII inhibitors using bio-layer interferometry
Cindy J. Choy & Clifford E. Berkman
Pages: 1690-1693
Published online: 12 Feb 2016
AbstractforA method to determine the mode of binding for GCPII inhibitors using bio-layer interferometry | Full Text | References | PDF (557.8 KB) | Supplemental
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Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives
Ahmed G. Eissa, James A. Blaxland, Rhodri O. Williams, Kamel A. Metwally, Sobhy M. El-Adl, El-Sayed M. Lashine, Leslie W. J. Baillie & Claire Simons
Pages: 1694-1697
Published online: 22 Feb 2016
AbstractforTargeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives | Full Text | References | PDF (771.7 KB) | Supplemental
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Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes
İlhami Gülçin, Andrea Scozzafava, Claudiu T. Supuran, Zeynep Koksal, Fikret Turkan, Songül Çetinkaya, Zeynebe Bingöl, Zübeyir Huyut & Saleh H. Alwasel
Pages: 1698-1702
Published online: 10 Feb 2016
AbstractforRosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes | Full Text | References | PDF (259.6 KB)
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Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening
Maria Concetta Gidaro, Stefano Alcaro, Daniela Secci, Daniela Rivanera, Adriano Mollica, Mariangela Agamennone, Letizia Giampietro & Simone Carradori
Pages: 1703-1706
Published online: 17 Mar 2016
AbstractforIdentification of new anti-Candida compounds by ligand-based pharmacophore virtual screening | Full Text | References | PDF (472.6 KB) | Supplemental
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Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry
Mikhail Krasavin, Roman Stavniichuk, Sergey Zozulya, Petro Borysko, Daniela Vullo & Claudiu T. Supuran
Pages: 1707-1711
Published online: 16 Mar 2016
AbstractforDiscovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry | Full Text | References | PDF (683 KB) | Supplemental
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Establishment of an effective TLC bioautographic method for the detection of Mycobacterium tuberculosis H37Ra phosphoglucose isomerase inhibition by phosphoenolpyruvate
Katarzyna Paradowska, Beata Polak, Adam Chomicki & Grażyna Ginalska
Pages: 1712-1717
Published online: 17 Mar 2016
AbstractforEstablishment of an effective TLC bioautographic method for the detection of Mycobacterium tuberculosis H37Ra phosphoglucose isomerase inhibition by phosphoenolpyruvate | Full Text | References | PDF (497.2 KB)
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Synthesis of new thieno[2,3-b]pyridine derivatives as pim-1 inhibitors
Bassem H. Naguib & Hala B. El-Nassan
Pages: 1718-1725
Published online: 22 Mar 2016
AbstractforSynthesis of new thieno[2,3-b]pyridine derivatives as pim-1 inhibitors | Full Text | References | PDF (388.1 KB)
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Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis
María J. Zaro, Ana Bortolotti, Leonardo E. Riafrecha, Analía Concellón, Héctor R. Morbidoni & Pedro A. Colinas
Pages: 1726-1730
Published online: 05 May 2016
AbstractforAnti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis | Full Text | References | PDF (422.9 KB)
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Editorial Board

Editorial Board
Page: ebi
Published online: 28 Sep 2016
CitationforEditorial Board | Full Text | PDF (24.9 KB)
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