Figure 1. Structures of known GCPII inhibitors and biotinylated analogs.
Figure 2. Dissociation of the irreversible GCP II inhibitor 3 (Biotin-PEG12-CTT54), slowly-reversible inhibitor 4 (Biotin-PEG12-CTT54.2), and reversible inhibitor 6 (Biotin-PEG12-Lys-Glu urea), compound structures adjacent to the curves, in (50 mM TRIS, pH 7.4 with 1% X-100 trition) buffer containing 14 μM CTT54 (1).
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