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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 6
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Short Communication

Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes

İlhami GülçinDepartment of Chemistry, Ataturk University, Erzurum, Turkey, ;Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia, Correspondence[email protected]
,
Andrea ScozzafavaDipartimento Di Chimica Ugo Schiff, Università Degli Studi Di Firenze, via Della Lastruccia 3, Sesto Fiorentino (Firenze), Italy,
,
Claudiu T. SupuranDipartimento Di Chimica Ugo Schiff, Università Degli Studi Di Firenze, via Della Lastruccia 3, Sesto Fiorentino (Firenze), Italy, ;Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università Degli Studi Di Firenze, via U. Schiff 6, Sesto Fiorentino (Florence), Italy, Correspondence[email protected]
,
Zeynep KoksalDepartment of Chemistry, Ataturk University, Erzurum, Turkey,
,
Fikret TurkanHealth Services Vocational School, Igdır University, Igdır, Turkey, and
,
Songül ÇetinkayaDepartment of Chemistry, Ataturk University, Erzurum, Turkey,
,
Zeynebe BingölDepartment of Chemistry, Ataturk University, Erzurum, Turkey,
,
Zübeyir HuyutDepartment of Biochemistry, Faculty of Medical, Yüzüncü Yıl University, Van, Turkey
&
Saleh H. AlwaselDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia,
show all
Pages 1698-1702 | Received 09 Dec 2015, Accepted 21 Dec 2015, Published online: 10 Feb 2016

Figures & data

Figure 1. Chemical structure of rosmarinic acid as glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes inhibitor.

Figure 1. Chemical structure of rosmarinic acid as glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes inhibitor.

Table 1. Inhibition constants (Ki) of rosmarinic acid against CA IX and XII isoenzymes, AChE, BChE, LPO and GST enzymes.

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