Research Spotlight: Drug Bioanalysis and Biomarker Discovery at The Commissariat à L’énergie Atomique et Aux Énergies Alternatives

Figures & data

Figure 1. The Commissariat à l‘énergie atomique et aux énergies alternatives site at Saclay south of Paris is home to research and innovation in nuclear energy, materials science, technology and the life sciences, our laboratory’s sphere of expertise.

Figure 2. Concentration–time course of the active intracellular metabolite of zidovudine (AZT-TP) in newborns, as a function of age after zidovudine treatment.

AZT-TP: Zidovudine triphosphate.

Figure 3. Complementary strategies for metabolite database building.

Figure 4. Ricin detection by activity- and structure-based approaches.

The N-glycosidase activity of ricin was first exploited by quantifying the adenine released from an RNA template by LC–MS/MS and isotope dilution. A complementary approach involving MALDI-TOF-MS has also been developed to quantitatively and specifically measure tryptic fragments from ricin. In both cases, ricin was first isolated by immunoaffinity to provide greater specificity and facilitate detection in complex matrices.