Representative publications
Bioanalysis & pharmacology
- Pruvost A , NegredoE, TheodoroFet al. Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir. Antimicrob. Agents Chemother. 53, 1937–1943 (2009).
- Bousquet L , PruvostA, GuyotACet al. Combination of tenofovir and emtricitabine plus efavirenz: in vitro modulation of ABC transporter and intracellular drug accumulation. Antimicrob. Agents Chemother. 53, 896–902 (2009).
- Pruvost A , TheodoroF, AgrofoglioLet al. Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells. J. Mass Spectrom. 43, 224–233 (2008).
- Durand-Gasselin L , PruvostA, DeheeAet al. High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers. Antimicrob. Agents Chemother. 52, 2555–2563 (2008).
MS-based metabolomics
- Kaur H , KumarC, JunotCet al. Dug1p is a Cys-Gly peptidase of the g-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J. Biol. Chem. 284, 14493–14502 (2009).
- Werner E , HeilierJF, DucruixCet al. Mass spectrometry for the identification of the discriminating signals from metabolomics: current status and future trends. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci871, 143–163 (2008).
- Madalinski G , GodatE, AlvesSet al. Direct introduction of biological samples into a LTQ-Orbitrap hybrid mass spectrometer as a tool for fast metabolome analysis. Anal. Chem. 80, 3291–3303 (2008).
- Werner E , CroixmarieV, UmbdenstockTet al. Mass spectrometry-based metabolomics: accelerating the characterization of discriminating signals by combining statistical correlations and ultrahigh resolution. Anal. Chem. 80, 4918–4932 (2008).
Biomarkers of recombinant protein exposure
- Ezan E , DuboisM, BecherFet al. Bioanalysis of recombinant proteins and antibodies by mass spectrometry. Analyst134, 825–834 (2009).
- Fenaille F , NonyE, ChabreHet al. Mass spectrometric investigation of molecular variability of grass pollen group 1 allergens. J. Proteome Res. 8, 4014–4027 (2009).
- Dubois M , FenailleF, ClementGet al. Immunopurification and mass spectrometric quantification of the active form of a chimeric therapeutic antibody in human serum. Anal. Chem. 80, 1737–1745 (2008).
- Becher F , PruvostA, ClementGet al. Quantification of small therapeutic proteins in plasma by liquid chromatography-tandem mass spectrometry: application to an elastase inhibitor EPI-hNE4. Anal. Chem. 78, 2306–2313 (2006).
Biomarkers of bioterrorism agents
- Manduzio H , MarteletA, EzanEet al. Comparison of approaches for purifying and desalting polymerase chain reaction products prior to electrospray ionization mass spectrometry. Anal. Biochem. 398(2), 272–274 (2010).
- Duriez E , GoossensPL, BecherFet al. Femtomolar detection of the anthrax edema factor in human and animal plasma. Anal. Chem. 81, 5935–5941 (2009).
- Duriez E , FenailleF, TabetJCet al. Detection of ricin in complex samples by immunocapture and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Proteome Res. 7, 4154–4163 (2008)
- Becher F , DuriezE, VollandHet al. Detection of functional ricin by immunoaffinity and liquid chromatography-tandem mass spectrometry. Anal. Chem. 79, 659–665 (2007).