https://orcid.org/0000-0003-1082-9499
Abstract
Background: To find alternative molecules against Klebsiella pneumonia, Proteus mirabilis and methicillin-resistant Staphylococcus aureus, new enoxacin derivatives were synthesized and screened. Methods: All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 μg/ml) and standard cefixime (82 μg/ml). Compounds 2, 3 and 5 significantly downregulated the gene expression of biofilm-forming genes. Conclusion: Based on our results, these molecules may serve as potential drug candidates to cure several bacterial infections in the future.
Graphical Abstract
Supplementary data
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Financial & competing interests disclosure
The authors acknowledge the financial support of Sindh Higher Education Commission (SHEC), Pakistan vide letter No. NO.DD/SHEC/1-14/2014, Project code SHEC/SRSP/Med-3/15/2021-2 and Higher Education Commission, Pakistan vide letter No. 7279/Sindh/ NRPU/R and D/HEC/ 2017. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.