Recent Advances in Anti-Coxsackievirus A16 Viral Drug Research

Abstract

Hand, foot and mouth disease, a childhood disorder caused by enteroviruses, is intermittently endemic in the Asia-Pacific region and endangers the lives of many infants and young children. Coxsackievirus A16 (CV-A16) is one of the major pathogens causing hand, foot, and mouth disease on occasion, resulting in catastrophic neurological sequelae and patient death. Currently, no clinical interventions are available that completely block the CV-A16 infection. Therefore, research on anti-CV-A16 treatment continues to be a significant focus of interest. This report provides a detailed background on and an introduction to CV-A16; a description of the viral gene and protein structures and a summary of the current advances in pharmaceutical targets, drug research and other related areas.

Keywords: :

• antiviral drugs
• CV-A16
• drug targets
• enterovirus
• HFMD
• research progress
• vaccine

Author contributions

X Yuan and Z Liu contributed equally to this work. L Wan, W Liu and Y Huang were involved in data collection. S Cao designed this work. X Yuan and Z Liu wrote the manuscript, and all authors have approved the final version of the manuscript.

Financial & competing interests disclosure

The authors gratefully acknowledge financial support from the program for Wuhan Institute of Technology (No. CX2021001). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.