Recent Advances in Anti-Coxsackievirus A16 Viral Drug Research

References

• Yi EJ , ShinYJ , KimJH , KimTG , ChangSY. Enterovirus 71 infection and vaccines. Clin. Exp. Vaccine Res.6(1), 4–14 (2017).
   PubMed Web of Science ®Google Scholar
• Fonseca EL , CaldartRV , FreitasFSet al. Emergence of extensively drug-resistant international clone IC-6 Acinetobacter baumannii carrying blaOXA-72 and blaCTX-M-115 in the Brazilian Amazon region. J. Glob. Antimicrob. Resist.20, 18–21 (2020).
   PubMed Web of Science ®Google Scholar
• Zhao Y , ZhouD , NiTet al. Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of coxsackie virus A10. Nat. Commun.11(1), 38 (2020).
   PubMed Web of Science ®Google Scholar
• Tan X , HuangX , ZhuSet al. The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008. PLOS ONE6(9), e25662 (2011).
   PubMed Web of Science ®Google Scholar
• Yang Y , WangH , GongEet al. Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study. Hum. Pathol.40(9), 1288–1295 (2009).
   PubMed Web of Science ®Google Scholar
• Chen X , TanX , LiJet al. Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. PLOS ONE8(12), e82861 (2013).
   PubMed Web of Science ®Google Scholar
• Alsop J , FlewettTH , FosterJR. “Hand-foot-and-mouth disease” in Birmingham in 1959. Brit. Med. J.2(5214), 1708–1711 (1960).
   PubMedGoogle Scholar
• Cox JA , HiscoxJA , SolomonT , OoiMH , NgLFP. Immunopathogenesis and virus-host interactions of enterovirus 71 in patients with hand, foot and mouth disease. Front. Microbiol.8, 2249 (2017).
   PubMed Web of Science ®Google Scholar
• Chang LY , HuangLM , GauSSet al. Neurodevelopment and cognition in children after enterovirus 71 infection. N. Engl. J. Med.356(12), 1226–1234 (2007).
   PubMed Web of Science ®Google Scholar
• Mao Q , WangY , YaoXet al. Coxsackievirus A16: epidemiology, diagnosis, and vaccine. Hum. Vaccin. Immunother.10(2), 360–367 (2014).
   PubMed Web of Science ®Google Scholar
• Xu W , LiuCF , YanLet al. Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. Virol. J.9, 8 (2012).
   PubMed Web of Science ®Google Scholar
• Song Y , HeS , YuNet al. Cloning, expression and antigenic analysis of VP1–VP4 gene encoding the structural protein of coxsackie virus A16. Nan Fang Yi Ke Da Xue Xue Bao32(12), 1713–1717 (2012).
   PubMedGoogle Scholar
• Ranganathan S , SinghS , PohCL , ChowVT. The hand, foot and mouth disease virus capsid: sequence analysis and prediction of antigenic sites from homology modelling. Appl. Bioinformatics1(1), 43–52 (2002).
   PubMedGoogle Scholar
• Zou XN , ZhangXZ , WangB , QiuYT. Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. Braz. J. Infect. Dis.16(5), 457–465 (2012).
   PubMed Web of Science ®Google Scholar
• Song J , HuY , LiJet al. Expression of type-iota interferon production pathway-related genes induced by infection due to enterovirus 71 or coxsackievirus A16 in normal human airway epithelial cells. Bing Du Xue Bao32(6), 694–701 (2016).
   PubMedGoogle Scholar
• Shi J , HuangX , LiuQ , HuangZ. Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16. Vaccine31(17), 2130–2136 (2013).
   PubMed Web of Science ®Google Scholar
• Svitkin YV , ImatakaH , KhaleghpourK , KahvejianA , LiebigHD , SonenbergN. Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. RNA7(12), 1743–1752 (2001).
   PubMed Web of Science ®Google Scholar
• Yogarajah T , OngKC , PereraD , WongKT. RSAD2 and AIM2 modulate coxsackievirus A16 and enterovirus A71 replication in neuronal cells in different ways that may be associated with their 5′ nontranslated regions. J. Virol.92(6),e01914–17 (2018).
   PubMed Web of Science ®Google Scholar
• Zoll J , HeusHA , Van KuppeveldFJ , MelchersWJ. The structure–function relationship of the enterovirus 3′-UTR. Virus Res.139(2), 209–216 (2009).
   PubMed Web of Science ®Google Scholar
• Merkle I , Van OoijMJ , Van KuppeveldFJet al. Biological significance of a human enterovirus B-specific RNA element in the 3′ nontranslated region. J. Virol.76(19), 9900–9909 (2002).
   PubMed Web of Science ®Google Scholar
• Oberste MS , MaherK , KilpatrickDR , PallanschMA. Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J. Virol.73(3), 1941–1948 (1999).
   PubMed Web of Science ®Google Scholar
• Li Y , ZhuR , QianYet al. Comparing enterovirus 71 with coxsackievirus A16 by analyzing nucleotide sequences and antigenicity of recombinant proteins of VP1s and VP4s. BMC Microbiol.11, 246 (2011).
   PubMed Web of Science ®Google Scholar
• Smyth MS , MartinJH. Picornavirus uncoating. Mol. Pathol.55(4), 214–219 (2002).
   PubMedGoogle Scholar
• Hyypia T , StanwayG. Biology of coxsackie A viruses. Adv. Virus Res.42, 343–373 (1993).
   PubMed Web of Science ®Google Scholar
• Oberste MS , PenarandaS , MaherK , PallanschMA. Complete genome sequences of all members of the species human enterovirus A. J. Gen. Virol.85(Pt 6), 1597–1607 (2004).
   PubMed Web of Science ®Google Scholar
• Singh S , PohCL , ChowVT. Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000). Microbiol. Immunol.46(11), 801–808 (2002).
   PubMed Web of Science ®Google Scholar
• Brown BA , KilpatrickDR , ObersteMS , PallanschMA. Serotype-specific identification of enterovirus 71 by PCR. J. Clin. Virol.16(2), 107–112 (2000).
   PubMed Web of Science ®Google Scholar
• Li L , HeY , YangHet al. Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China. J. Clin. Microbiol.43(8), 3835–3839 (2005).
   PubMed Web of Science ®Google Scholar
• Zhang Y , WangD , YanDet al. Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China. J. Clin. Microbiol.48(2), 619–622 (2010).
   PubMed Web of Science ®Google Scholar
• Zong W , HeY , YuSet al. Molecular phylogeny of coxsackievirus A16 in Shenzhen, China, from 2005 to 2009. J. Clin. Microbiol.49(4), 1659–1661 (2011).
   PubMed Web of Science ®Google Scholar
• Yang E , ZhaoH , ZhangYet al. A comparative study of the characteristics of two coxsackie A virus type 16 strains (genotype B). Sci. China Life Sci.55(4), 336–342 (2012).
   PubMed Web of Science ®Google Scholar
• Yogarajah T , OngKC , PereraD , WongKT. Enterovirus A71 and coxsackievirus A16 show different replication kinetics in human neuronal and non-neuronal cell lines. Arch. Virol.162(3), 727–737 (2017).
   PubMed Web of Science ®Google Scholar
• Ong KC , WongKT. Understanding enterovirus 71 neuropathogenesis and its impact on other neurotropic enteroviruses. Brain Pathol.25(5), 614–624 (2015).
   PubMed Web of Science ®Google Scholar
• Wang CY , HuangAC , HourMJet al. Antiviral potential of a novel compound CW-33 against enterovirus A71 via inhibition of viral 2A protease. Viruses7(6), 3155–3171 (2015).
   PubMed Web of Science ®Google Scholar
• Lu J , YiL , ZhaoJet al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J. Virol.86(7), 3767–3776 (2012).
   PubMed Web of Science ®Google Scholar
• Wen W , QiZ , WangJ. The function and mechanism of enterovirus 71 (EV71) 3C protease. Curr. Microbiol.77(9), 1968–1975 (2020).
   PubMed Web of Science ®Google Scholar
• Rui Y , SuJ , WangHet al. Disruption of MDA5-mediated innate immune responses by the 3C proteins of coxsackievirus A16, coxsackievirus A6, and enterovirus D68. J. Virol.91(13),e00546–17 (2017).
   PubMed Web of Science ®Google Scholar
• Lu G , QiJ , ChenZet al. Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J. Virol.85(19), 10319–10331 (2011).
   PubMed Web of Science ®Google Scholar
• Tee HK , ZainolMI , SamIC , ChanYF. Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis. Expert Rev. Anti. Infect.Ther.19(6), 733–747 (2021).
   PubMed Web of Science ®Google Scholar
• Cui S , WangJ , FanTet al. Crystal structure of human enterovirus 71 3C protease. J. Mol. Biol.408(3), 449–461 (2011).
   PubMed Web of Science ®Google Scholar
• Cai Q , YameenM , LiuWet al. Conformational plasticity of the 2A proteinase from enterovirus 71. J. Virol.87(13), 7348–7356 (2013).
   PubMed Web of Science ®Google Scholar
• Sun Y , WangX , YuanSet al. An open conformation determined by a structural switch for 2A protease from coxsackievirus A16. Protein Cell4(10), 782–792 (2013).
   PubMed Web of Science ®Google Scholar
• Foeger N , GlaserW , SkernT. Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases. J. Biol. Chem.277(46), 44300–44309 (2002).
   PubMed Web of Science ®Google Scholar
• Jetsadawisut W , NuthoB , MeeprasertAet al. Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: a molecular dynamics study. Biophys. Chem.219, 9–16 (2016).
   PubMed Web of Science ®Google Scholar
• Lei X , XiaoX , WangJ. Innate immunity evasion by enteroviruses: insights into virus-host interaction. Viruses8(1), (2016).
   PubMed Web of Science ®Google Scholar
• Wu J , ChenZJ. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol.32, 461–488 (2014).
   PubMed Web of Science ®Google Scholar
• Liu S , CaiX , WuJet al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science347(6227), aaa2630 (2015).
   PubMed Web of Science ®Google Scholar
• Lee CC , KuoCJ , KoTPet al. Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J. Biol. Chem.284(12), 7646–7655 (2009).
   PubMed Web of Science ®Google Scholar
• Sweeney TR , Roque-RosellN , BirtleyJR , LeatherbarrowRJ , CurryS. Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis. J. Virol.81(1), 115–124 (2007).
   PubMed Web of Science ®Google Scholar
• Tian X , LuG , GaoFet al. Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of porcine reproductive and respiratory syndrome virus (PRRSV). J. Mol. Biol.392(4), 977–993 (2009).
   PubMed Web of Science ®Google Scholar
• Sripattaraphan A , SanachaiK , ChavasiriW , BoonyasuppayakornS , MaitaradP , RungrotmongkolT. Computational screening of newly designed compounds against coxsackievirus A16 and enterovirus A71. Molecules27(6), 22 (2022).
   Web of Science ®Google Scholar
• Cao Y , LeiE , LiLet al. Antiviral activity of mulberroside C against enterovirus A71 in vitro and in vivo. Eur. J. Pharmacol.906, 174204 (2021).
   PubMed Web of Science ®Google Scholar
• De Palma AM , ThibautHJ , VanDer Linden Let al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob. Agents Chemother.53(5), 1850–1857 (2009).
   PubMed Web of Science ®Google Scholar
• Tang Q , LiS , DuLet al. Emetine protects mice from enterovirus infection by inhibiting viral translation. Antiviral Res.173, 104650 (2020).
   PubMed Web of Science ®Google Scholar
• Patick AK , BinfordSL , BrothersMAet al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob. Agents Chemother.43(10), 2444–2450 (1999).
   PubMed Web of Science ®Google Scholar
• Binford SL , MaldonadoF , BrothersMAet al. Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob. Agents Chemother.49(2), 619–626 (2005).
   PubMed Web of Science ®Google Scholar
• Sun L , MeijerA , FroeyenMet al. Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrob. Agents Chemother.59(12), 7782–7785 (2015).
   PubMed Web of Science ®Google Scholar
• Tan J , GeorgeS , KusovYet al. 3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J. Virol.87(8), 4339–4351 (2013).
   PubMed Web of Science ®Google Scholar
• Lacroix C , GeorgeS , LeyssenP , HilgenfeldR , NeytsJ. The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrob. Agents Chemother.59(9), 5814–5818 (2015).
   PubMed Web of Science ®Google Scholar
• Li P , YuJ , HaoFet al. Discovery of potent EV71 capsid inhibitors for treatment of HFMD. ACS Med. Chem. Lett.8(8), 841–846 (2017).
   PubMed Web of Science ®Google Scholar
• Chen J , YeX , ZhangXYet al. Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses. Cell Discov5, 4 (2019).
   PubMed Web of Science ®Google Scholar
• Thibaut HJ , DePalma AM , NeytsJ. Combating enterovirus replication: state-of-the-art on antiviral research. Biochem. Pharmacol.83(2), 185–192 (2012).
   PubMed Web of Science ®Google Scholar
• El-Beshbishy HA , SingabAN , SinkkonenJ , PihlajaK. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci.78(23), 2724–2733 (2006).
   PubMed Web of Science ®Google Scholar
• Jo SP , KimJK , LimYH. Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet. Food Chem. Toxicol.65, 213–218 (2014).
   PubMed Web of Science ®Google Scholar
• Rhoden E , LiuHM , Wang-ChernSW , ObersteMS. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res.98(2), 186–191 (2013).
   PubMed Web of Science ®Google Scholar
• Galabov AS , NikolovaI , Vassileva-PenchevaR , StoyanovaA. Antiviral combination approach as a perspective to combat enterovirus infections. Pril (Makedon Akad Nauk Umet Odd Med Nauki)36(2), 91–99 (2015).
   PubMedGoogle Scholar
• Lanko K , ShiC , PatilSet al. Assessing in vitro resistance development in enterovirus A71 in the context of combination antiviral treatment. ACS Infect. Dis.7(10), 2801–2806 (2021).
   PubMed Web of Science ®Google Scholar
• Li R , LiuL , MoZet al. An inactivated enterovirus 71 vaccine in healthy children. N. Engl. J. Med.370(9), 829–837 (2014).
   PubMed Web of Science ®Google Scholar
• Zhu FC , MengFY , LiJXet al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet381(9882), 2024–2032 (2013).
   PubMed Web of Science ®Google Scholar
• Wei M , MengF , WangSet al. 2-year efficacy, immunogenicity, and safety of vigoo enterovirus 71 vaccine in healthy Chinese children: a randomized open-label study. J. Infect. Dis.215(1), 56–63 (2017).
   PubMed Web of Science ®Google Scholar
• Lim ZQ , NgQY , NgJWQ , MahendranV , AlonsoS. Recent progress and challenges in drug development to fight hand, foot and mouth disease. Expert Opin. Drug Discov.15(3), 359–371 (2020).
   PubMed Web of Science ®Google Scholar
• Yang T , XieT , SongXet al. Safety and immunogenicity of an experimental live combination vaccine against enterovirus 71 and coxsackievirus A16 in rhesus monkeys. Hum. Vaccin. Immunother.16(7), 1586–1594 (2020).
   PubMed Web of Science ®Google Scholar
• Cui B , CaiF , GaoFet al. A uniform quantitative enzyme-linked immunosorbent assay for coxsackievirus A16 antigen in vaccine. Hum. Vaccin. Immunother.17(2), 381–388 (2021).
   PubMed Web of Science ®Google Scholar
• Cai Y , LiuQ , HuangXet al. Active immunization with a coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection. Vaccine31(18), 2215–2221 (2013).
   PubMed Web of Science ®Google Scholar
• Li J , LiuG , LiuXet al. Optimization and characterization of candidate strain for coxsackievirus A16 inactivated vaccine. Viruses7(7), 3891–3909 (2015).
   PubMed Web of Science ®Google Scholar
• Lim H , InHJ , LeeJAet al. The immunogenicity and protection effect of an inactivated coxsackievirus A6, A10, and A16 vaccine against hand, foot, and mouth disease. Vaccine36(24), 3445–3452 (2018).
   PubMed Web of Science ®Google Scholar
• Cao Y , LeiE , WangXet al. Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo. Antiviral Res.195, 105091 (2021).
   PubMed Web of Science ®Google Scholar
• Wang CY , HuangSC , LaiZRet al. Eupafolin and ethyl acetate fraction of Kalanchoe gracilis stem extract show potent antiviral activities against enterovirus 71 and coxsackievirus A16. Evid. Based Complement. Alternat. Med.2013, 591354 (2013).
   PubMed Web of Science ®Google Scholar
• Song JH , ParkK , ShimAet al. Complete sequence analysis and antiviral screening of medicinal plants for human coxsackievirus A16 isolated in Korea. Osong Public Health Res. Perspect.6(1), 52–58 (2015).
   PubMedGoogle Scholar
• Wang H , GuoT , YangY , YuL , PanX , LiY. Lycorine derivative LY-55 inhibits EV71 and CVA16 replication through downregulating autophagy. Front. Cell Infect. Microbiol.9, 277 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang Z , BaiJ , ZengYet al. Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review. Pharm. Biol.58(1), 950–958 (2020).
   PubMed Web of Science ®Google Scholar
• Liu X , ZhangX , LiJet al. Effects of acetylshikonin on the infection and replication of coxsackievirus A16 invitro and in vivo. J. Nat. Prod.82(5), 1089–1097 (2019).
   PubMed Web of Science ®Google Scholar
• Wu KX , ChuJJ. Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor. Antiviral Res.143, 122–133 (2017).
   PubMed Web of Science ®Google Scholar
• Xu L , SuW , JinJet al. Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. Viruses6(7), 2778–2795 (2014).
   PubMed Web of Science ®Google Scholar
• Zeng S , MengX , HuangQet al. Spiramycin and azithromycin, safe for administration to children, exert antiviral activity against enterovirus A71 in vitro and in vivo. Int. J. Antimicrob. Agents53(4), 362–369 (2019).
   PubMed Web of Science ®Google Scholar
• Min JY , JangYJ. Macrolide therapy in respiratory viral infections. Mediators Inflamm.2012, 649570 (2012).
   PubMed Web of Science ®Google Scholar
• Xue F , LuoX , YeC , YeW , WangY. Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses. Bioorg. Med. Chem.19(8), 2641–2649 (2011).
   PubMed Web of Science ®Google Scholar
• Yang YJ , LiuJN , PanXD. Synthesis and antiviral activity of lycorine derivatives. J. Asian Nat. Prod. Res.22(12), 1188–1196 (2020).
   PubMed Web of Science ®Google Scholar
• Sun J , YogarajahT , LeeRCHet al. Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications. Sci. Rep.10(1), 8159 (2020).
   PubMed Web of Science ®Google Scholar
• Liu Z , XiaS , WangXet al. Sodium copper chlorophyllin is highly effective against enterovirus (EV) A71 infection by blocking its entry into the host cell. ACS Infect. Dis.6(5), 882–890 (2020).
   PubMed Web of Science ®Google Scholar
• Zhang X , WangH , LiYet al. Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus A16. Molecules18(5), 5059–5071 (2013).
   PubMed Web of Science ®Google Scholar
• De Colibus L , WangX , TijsmaAet al. Structure elucidation of coxsackievirus A16 in complex with GPP3 informs a systematic review of highly potent capsid binders to enteroviruses. PLOS Pathog.11(10), e1005165 (2015).
   PubMed Web of Science ®Google Scholar
• Ma GH , YeY , ZhangDet al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur. J. Med. Chem.124, 981–991 (2016).
   PubMed Web of Science ®Google Scholar
• Gao Q , YuanS , ZhangCet al. Discovery of itraconazole with broad-spectrum in vitro antienterovirus activity that targets nonstructural protein 3A. Antimicrob. Agents Chemother.59(5), 2654–2665 (2015).
   PubMed Web of Science ®Google Scholar
• Wang Y , CaoL , ZhaiYet al. Inhibition of enterovirus 71 replication by an alpha-hydroxy-nitrile derivative NK-1.9 k. Antiviral Res.141, 91–100 (2017).
   PubMed Web of Science ®Google Scholar
• Yin H , ZhangX , WeiJ , LuS , BardelangD , WangR. Recent advances in supramolecular antidotes. Theranostics11(3), 1513–1526 (2021).
   PubMed Web of Science ®Google Scholar
• Quan J , ZhangX , DingYet al. Cucurbit[7]uril as a broad-spectrum antiviral agent against diverse RNA viruses. Virol. Sin.36(5), 1165–1176 (2021).
   PubMed Web of Science ®Google Scholar
• Tan JK , ChenR , LeeRCHet al. Discovery of novel andrographolide derivatives as antiviral inhibitors against human enterovirus A71. Pharmaceuticals (Basel)15(2), 115 (2022).
   PubMedGoogle Scholar
• Dai K , TanJK , QianW , LeeRCH , HannChu JJ , ZhouGC. Discovery of 14S-(2′-chloro-4′-nitrophenoxy)-8R/S,17-epoxy andrographolide as EV-A71 infection inhibitor. Biochem. Pharmacol.194, 114820 (2021).
   PubMed Web of Science ®Google Scholar
• Tan CW , ChanYF , SimKM , TanEL , PohCL. Inhibition of enterovirus 71 (EV-71) infections by a novel antiviral peptide derived from EV-71 capsid protein VP1. PLOS ONE7(5), e34589 (2012).
   PubMed Web of Science ®Google Scholar
• Fang Y , WangC , WangCet al. Antiviral peptides targeting the helicase activity of enterovirus nonstructural protein 2C. J. Virol.95(12),e02324–20 (2021).
   PubMed Web of Science ®Google Scholar
• Zhou B , XuL , ZhuRet al. A bispecific broadly neutralizing antibody against enterovirus 71 and coxsackievirus A16 with therapeutic potential. Antiviral Res.161, 28–35 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang D , ChenJ , Ba-TheinW. Hand-foot-mouth disease and use of steroids, intravenous immunoglobulin, and traditional Chinese herbs in a tertiary hospital in Shantou, China. BMC Complement. Altern. Med.18(1), 190 (2018).
   PubMedGoogle Scholar
• Chen X , WangC , XuLet al. A laboratory evaluation of medicinal herbs used in China for the treatment of hand, foot, and mouth disease. Evid. Based Complement. Alternat. Med.2013, 504563 (2013).
   PubMed Web of Science ®Google Scholar
• Ang WX , SarasvathyS , KuppusamyURet al. In vitro antiviral activity of medicinal mushroom Ganoderma neo-japonicum Imazeki against enteroviruses that caused hand, foot and mouth disease. Trop. Biomed.38(3), 239–247 (2021).
   PubMed Web of Science ®Google Scholar
• Yeo SG , SongJH , HongEHet al. Antiviral effects of Phyllanthus urinaria containing corilagin against human enterovirus 71 and coxsackievirus A16 in vitro. Arch. Pharm. Res.38(2), 193–202 (2015).
   PubMed Web of Science ®Google Scholar
• Wang J , ChenX , WangWet al. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J. Ethnopharmacol.147(1), 114–121 (2013).
   PubMed Web of Science ®Google Scholar
• Lin H , HuangL , ZhouJet al. Efficacy and safety of interferon-alpha2b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double-blind trial. Arch. Virol.161(11), 3073–3080 (2016).
   PubMed Web of Science ®Google Scholar
• Russell CD , SchwarzeJ. The role of pro-resolution lipid mediators in infectious disease. Immunology141(2), 166–173 (2014).
   PubMed Web of Science ®Google Scholar
• Khademian M , FarhangpajouhN , ShahsanaeeA , BahreynianM , MirshamsiM , KelishadiR. Effects of zinc supplementation on subscales of anorexia in children: a randomized controlled trial. Pak. J. Med. Sci.30(6), 1213–1217 (2014).
   PubMed Web of Science ®Google Scholar
• Velástegui J , CovaL , GalarzaY , FierroP , LeónBaryolo L , BustillosA. A case report of hand, foot, and mouth disease with necrotizing mucocutaneous lesions. Medwave19(7), e7683 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang HP , WangL , QianJHet al. Efficacy and safety of ribavirin aerosol in children with hand-foot-mouth disease. Zhongguo Dang Dai Er Ke Za Zhi16(3), 272–276 (2014).
   PubMedGoogle Scholar
• Zhao Y , SunY , AlolgaRN , MaG , WangF. The use of oseltamivir as adjunctive therapy for the treatment of hand-food-and-mouth disease: a meta-analysis of randomized clinical trials. Front. Pharmacol.12, 653691 (2021).
   PubMed Web of Science ®Google Scholar
• Faulkner CF , GodboltAM , DeambrosisB , TriscottJ. Hand, foot and mouth disease in an immunocompromised adult treated with aciclovir. Australas. J. Dermatol.44(3), 203–206 (2003).
   PubMedGoogle Scholar
• Shelley WB , HashimM , ShelleyED. Acyclovir in the treatment of hand-foot-and-mouth disease. Cutis57(4), 232–234 (1996).
   PubMed Web of Science ®Google Scholar