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Future Medicinal Chemistry Volume 7, 2015 - Issue 5
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Review

Agents that Inhibit Bacterial Biofilm Formation

Nira Rabin1 Department of Chemistry & Biochemistry, University of Maryland, College Park, MD20742, USAView further author information
,
Yue Zheng1 Department of Chemistry & Biochemistry, University of Maryland, College Park, MD20742, USAView further author information
,
Clement Opoku-Temeng1 Department of Chemistry & Biochemistry, University of Maryland, College Park, MD20742, USAView further author information
,
Yixuan Du1 Department of Chemistry & Biochemistry, University of Maryland, College Park, MD20742, USAView further author information
,
Eric Bonsu2 Department of Natural Sciences, Bowie State University, 14000 Jericho Park Road, Bowie, MD20715, USAView further author information
&
Herman O Sintim1 Department of Chemistry & Biochemistry, University of Maryland, College Park, MD20742, USACorrespondence[email protected]
View further author information
Pages 647-671 | Published online: 29 Apr 2015

Figures & data

Figure 1.  Natural compounds with 2-aminoimidazole moiety.
Figure 1.  Natural compounds with 2-aminoimidazole moiety.
Figure 2.  2-aminoimidazole based biofilm inhibitors.
Figure 2.  2-aminoimidazole based biofilm inhibitors.
Figure 3.  2-aminoimidazole and menthyl carbamate library.
Figure 3.  2-aminoimidazole and menthyl carbamate library.
Figure 4.  Benzimidazoles analogs.
Figure 4.  Benzimidazoles analogs.
Figure 5.  Indole–triazole-amide analogs.
Figure 5.  Indole–triazole-amide analogs.
Figure 6.  Plant-derived biofilm inhibitors.
Figure 6.  Plant-derived biofilm inhibitors.
Figure 7.  Resveratrol and its oligomers.
Figure 7.  Resveratrol and its oligomers.
Figure 8.  Sulfur derivatives with antibiofilm activities.
Figure 8.  Sulfur derivatives with antibiofilm activities.
Figure 9.  Brominated furanone analogs.
Figure 9.  Brominated furanone analogs.
Figure 10.  Bromopyrrole alkaloids.
Figure 10.  Bromopyrrole alkaloids.
Figure 11.  Skyllamycins and (-)-ageloxime D structures.
Figure 11.  Skyllamycins and (-)-ageloxime D structures.
Figure 12.  Cembranoids library for biofilm inhibition.

Data taken from [Citation88–90].

Figure 12.  Cembranoids library for biofilm inhibition.Data taken from [Citation88–90].
Figure 13.  Synthetic N-acyl homoserine lactone analogs.
Figure 13.  Synthetic N-acyl homoserine lactone analogs.
Figure 14.  Biofilm inhibition by carolacton.

(A) Carolacton structure. (B) Analog 59 structure. (C) Confocal microscopy imaging of Streptococcus mutans UA159 biofilm cells treated with 250 μM: (i) DMSO, (ii) carolacton and (iii) 59.

Reproduced with permission from [Citation104] © American Chemical Society (2014).

Figure 14.  Biofilm inhibition by carolacton. (A) Carolacton structure. (B) Analog 59 structure. (C) Confocal microscopy imaging of Streptococcus mutans UA159 biofilm cells treated with 250 μM: (i) DMSO, (ii) carolacton and (iii) 59.Reproduced with permission from [Citation104] © American Chemical Society (2014).
Figure 15.  Molecules that interfere with the formation of amyloid-like fibers.
Figure 15.  Molecules that interfere with the formation of amyloid-like fibers.
Figure 16.  Fatty acids that repress biofilm formation.
Figure 16.  Fatty acids that repress biofilm formation.
Figure 17.  NO donors.
Figure 17.  NO donors.
Figure 18.  Ionic liquids.
Figure 18.  Ionic liquids.

Table 1.  Peptides with antibiofilm activity.

Supplemental material

Supplemental Material 1

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