Figures & data
Figure 1. Key signaling and transcriptional events.
Events in (A) the HSR and (B) the UPR.
ER: Endoplasmic reticulum; ERAD: Endoplasmic reticulum-associated protein degradation; HSE: Heat shock element; HSR:Heat shock response; UPR:Unfolded protein response; UPRE:Unfolded protein response elements; UPS: Ubiquitin proteasome system.
Figure 2. The heat shock response and the unfolded protein response act together in exacerbating polyQ toxicity in Huntington's disease.
The ‘?’ indicates a possible albeit hitherto mostly unexplored direct connection between the HSR and the UPR.
ERAD: Endoplasmic reticulum-associated protein degradation; HSR: Heat shock response; UPR: Unfolded protein response.
