Figures & data
Figure 1. Blood flow and endothelium interactions in the microcirculation.
Shows schematic representation of the CFL and the RBC core and how it is visualized in vivo using intravital microscopy. (A) RBC core, (B) CFL and (C) endothelial lining.
Figure 2. Microvascular diameter and blood flow during hemorrhagic shock, with and without nitric oxide supplementation.
The infusion of NOnps promote an increase in blood flow, mainly determined by an increase in vascular diameter. This increase in blood flow promotes an increase in O2 delivery and thus reduces tissue damage.
NOnp: Nitric oxide-releasing nanoparticle.
Figure 3. Red blood cell mechanical changes during storage for 4 weeks with nitric oxide supplementation based on nitric oxide-releasing nanoparticles.
Elongations index as a function of shear stress after 4 weeks of storage.
NO-np: Nitric oxide-releasing nanoparticle.
Figure 4. Effect of nitric oxide supplementation on ventricular function.
The hamster closed chest method was used to simultaneously record pressure and volume of the left ventricle using a conductance catheter, during normovolemic anemia with or without NO supplementation. (A) SW/SV and (B) dP/dtmin were decreased after the NO supplementation. (C & D) show examples of the effect of supplementing NO on the ventricular pressure–volume relationship.
SW/SV: Stroke work per stoke volume.
