Figures & data
Figure 1. Working model for the role of tumor-secreted miR-214 in inducing tumor immune escape. After being processed into mature miRNA, tumor-specific miR-214 is packaged into microvesicles and secreted to the extracellular environment by tumor cells. Secreted miR-214 is then delivered by microvesicles to the recipient CD4+ T cells, in which it decreases PTEN protein expression and facilitates Treg expansion. Increased Treg population, in turn, leads to host immune suppression and tumor growth.
