Figures & data
Figure 1. Schematic view of the induction of Th17 by Ag presenting activated pDCs and subsequent impact on antitumor immunity. (A) pDCs in tumor and tumor-draining LN are maintained quiescent by the tumoral microenvironment («Tolerogenic pDC»). (B) However, vaccination of tumor-bearing mice using MHCII-restricted tumor derived peptide in the presence of CpG-B at tumor distal site induces Th17 cell differentiation by Ag presenting activated pDCs (« Immunogenic pDC»). (C) pDC-derived Th17 cells migrate to the tumor and induce the recruitment of immune cells, including DCs, pDCs, Th1, Tregs and CTLs. (D) Enhanced tumor-specific CTL infiltration allows tumor cell killing and control of tumor growth.
