Figure 1. HCT116 cells were transfected with a control plasmid or a plasmid encoding flag-XBP1u or flag-XBP1s. Twenty-four hours after transfection, the cells were subjected to glutamine starvation for 24 h, and the formation of GFP-LC3 punctate signals was observed.
Figure 2. A schematic model showing the relationship between autophagy and XBP1u-induced FOXO1 degradation.
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