Regulation of cadherin expression in nervous system development

Figures & data

Table 1. Type I and Type II classical cadherins with known heterotypic interactions

Type I	Heterotypic interactions	Type II	Heterotypic interactions
Cdh1 (E-cadherin)	Cdh2,^31 EGFR^139	Cdh5 (VE-cadherin)
Cdh2 (N-cadherin)	Cdh1,^31 Cdh4,^29^,^30 FGFR,^32 GluR2,^140 NMDAR^141 PCHD19^142^,^143	Cdh6/6B (K-cadherin)	Cdh7^27 Cdh9^28
Cdh3 (P-cadherin)		Cdh7	Cdh6B^27
Cdh4 (R-cadherin)	Cdh2^29^,^30	Cdh8	Cdh11^28
Cdh15 (M-cadherin)		Cdh9 (T1-cadherin)	Cdh6, 10^28
		Cdh10 (T2-cadherin)	Cdh9^28
		Cdh11 (OB-cadherin)	Cdh8,^28 FGFR^33
		Cdh12 (N-cadherin 2)
		Cdh18
		Cdh19
		Cdh20 (MN-cadherin)
		Cdh22 (PB-cadherin)
		Cdh24

Table 2. Transcription factors and signaling molecules controlling cadherin expression in the developing nervous system

Cadherin	Transcription factor or signal	Action	Cell type/notes	Methods	Organism^ǂ
N-cadherin	FoxD3	repress	neural tube	GOF, IHC	Ch^144
	Foxp2/4	repress	spinal cord LMC, cortex, Indirect by repression of Sox2	LOF/GOF, ChIP	Ch,M^65
	Gbx-2	repress	anterior neural	GOF, RT-PCR	X^145
	Pax2	activate	otic placode	LOF/GOF, IHC, genomic in silico	Ch^64
	Pax3	activate	animal cap assay/neural crest induction		X^146
	Pax6	activate	retina (not in trunk)	LOF MO/GOF, genomic in silico, in vivo ChIP, Real-time PCR	X^79
	Sox2/SoxB1	activate	neural/sensory placode	GOF, in silico, gel shift, IHC, ISH	Ch^63
	Sox2/Pax6	activate	lens placode, Sox2 (preplacodal)/ Pax6 (placodal) stage-dependent regulation of Ncad	LOF, IHC	M^78
	Steroid	induce	Hippocampus, spinal cord MN	GOF, RT-PCR, IHC	R^147^,^148
R-cadherin	Pax6	activate	forebrain forebrain brain	LOF, ISH LOF, ISH GOF, ISH	M^82 M^149 Z^80
	Shh	repress	brain, (indirect possible by repression Pax6)	GOF/ LOF mutant, ISH	Z^80
Cadherin-6/6B	Sox9	activate	neural tube	GOF, ISH	Ch^128
	Slug	repress	pre-migratory cranial NCC in complex with PHD12/Sin3A	LOF MO, QRT-PCR, ChIP, Luciferase assay	Ch^67 Ch^68
	BMP	induce	neural plate explant, neural tube	GOF, RT-PCR LOF via Noggin, ISH	Ch^105 Ch^106
	Wnt	induce	neural tube neural tube	GOF, QRT-PCR LOF dNLEF1, Xdd1, ISH	Ch^107 Ch^150
Cadherin-7	FoxD3	activate	neural tube	GOF, IHC genomic in silico ChIP	Ch^127^,^144 Ch^69 Ch-Prasad unpublished
	Pax7	repress	dorsal neural tube	GOF, IHC	Ch^133
	SoxE	activate	Sox9 neural tube Sox10 neural tube	GOF, ISH GOF, IHC genomic in silico	Ch^128 Ch^129 Ch^69
	BMP	induce	neural plate explant	GOF, RT-PCR	Ch^105
	Shh-low	induce	radial glia/lateral neural tube	GOF, IHC	Ch^133^,^134
	Shh-high	repress	ventral neural tube	GOF, IHC	Ch^133
	Wnt	induce	NCC	GOF, QRT-PCR genomic in silico	Ch^111 Ch^69
Cadherin-11	Bhlhb5/Prdm8	repress	dorsal telencephalon, corticospinal motor neurons	LOF, ChIP	M^70
	Wnt	induce	NCC	GOF, QRT-PCR	Ch^111
Cadherin-20	Er81	induce	ventral spinal cord	GOF, ISH	Ch,^115 suppl info
	Shh-high	induce repress	spinal cord LMC and hindbrain, sensory interneuron	GOF, LOF mPTc1^Δloop2 dom neg mutant, ISH GOF	Ch^124

ChIP, chromatin immunoprecipitation; GOF, gain of function; IHC, immunohistochemistry; ISH, in situ hybridization; LMC, lateral motor column; LOF, loss of function; MN, motor neuron; MO, morpholino antisense oligo; mPTc mouse Patched; NCC, neural crest cell; RT-PCR reverse transcriptase polymerase chain reaction; QRT-PCR quantitative real-time PCR. ^ǂCh, chicken; M, mouse; R, rat; X, xenopus; Z, zebrafish

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