1,468
Views
18
CrossRef citations to date
0
Altmetric
Clinical Study

Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients

, , , , , , , , & show all
Pages 888-896 | Received 10 May 2013, Accepted 29 Jul 2013, Published online: 12 Aug 2013

Figures & data

Figure 1. (A) PIK3CA mutation status in invasive epithelial tumors of Saudi Breast Cancer patients. The x-axis indicates relative frequency and y-axis shows mutation and change in amino acid. The total 21 missense mutations out of 81 total primary tumor samples (25.9%), 17 in exon 20 (81.0%), and 4 in exon 9 (19.0%). (B) The frequency of C3075T SNP (rs17849079) in disease-free control samples and in breast cancer patient population in Saudi Arabia. The frequency of SNP in breast cancer patients (7/81 or 8.6%) is significantly higher than those with disease-free controls (2/189 or 1.1%). *P value = 0.0032.

Figure 1. (A) PIK3CA mutation status in invasive epithelial tumors of Saudi Breast Cancer patients. The x-axis indicates relative frequency and y-axis shows mutation and change in amino acid. The total 21 missense mutations out of 81 total primary tumor samples (25.9%), 17 in exon 20 (81.0%), and 4 in exon 9 (19.0%). (B) The frequency of C3075T SNP (rs17849079) in disease-free control samples and in breast cancer patient population in Saudi Arabia. The frequency of SNP in breast cancer patients (7/81 or 8.6%) is significantly higher than those with disease-free controls (2/189 or 1.1%). *P value = 0.0032.

Table 1. Summary of PIK3CA mutational status and their clinicopathological features in BC samples

Table 2. Summary of PIK3CA mutational status and their clinicopathological features in CAF and their associated BC samples

Table 3. The associations between PIK3CA somatic mutation status and BC samples’ clinicopathologic features

Table 4. The associations between PIK3CA mutation type and clinicopathological variables

Figure 2. The Kaplan–Meier curves illustrating overall survival based on tumor PIK3CA mutational status.

Figure 2. The Kaplan–Meier curves illustrating overall survival based on tumor PIK3CA mutational status.
Supplemental material

Additional material

Download Zip (166.4 KB)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.