1,468
Views
18
CrossRef citations to date
0
Altmetric
Clinical Study

Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients

, , , , , , , , & show all
Pages 888-896 | Received 10 May 2013, Accepted 29 Jul 2013, Published online: 12 Aug 2013

References

  • Garcia M, Jemal A, Ward E, Center MM, Hao Y. Global Cancer Facts and Figures 2007. American Cancer Society 2007.
  • Al-Eid HS. Cancer Incidence Report: Saudi Arabia. National Cancer Registry 2004.
  • Porter P. “Westernizing” women’s risks? Breast cancer in lower-income countries. N Engl J Med 2008; 358:213 - 6; http://dx.doi.org/10.1056/NEJMp0708307; PMID: 18199859
  • Deramaudt T, Rustgi AK. Mutant KRAS in the initiation of pancreatic cancer. Biochim Biophys Acta 2005; 1756:97 - 101; PMID: 16169155
  • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759 - 67; http://dx.doi.org/10.1016/0092-8674(90)90186-I; PMID: 2188735
  • Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358:1148 - 59; http://dx.doi.org/10.1056/NEJMra072067; PMID: 18337604
  • Warnecke PM, Bestor TH. Cytosine methylation and human cancer. Curr Opin Oncol 2000; 12:68 - 73; http://dx.doi.org/10.1097/00001622-200001000-00012; PMID: 10687732
  • Orimo A, Weinberg RA. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 2006; 5:1597 - 601; http://dx.doi.org/10.4161/cc.5.15.3112; PMID: 16880743
  • Eng C, Leone G, Orloff MS, Ostrowski MC. Genomic alterations in tumor stroma. Cancer Res 2009; 69:6759 - 64; http://dx.doi.org/10.1158/0008-5472.CAN-09-0985; PMID: 19706759
  • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655 - 7; http://dx.doi.org/10.1126/science.296.5573.1655; PMID: 12040186
  • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7:606 - 19; http://dx.doi.org/10.1038/nrg1879; PMID: 16847462
  • Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007; 318:1108 - 13; http://dx.doi.org/10.1126/science.1145720; PMID: 17932254
  • Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304:554 - 554; http://dx.doi.org/10.1126/science.1096502; PMID: 15016963
  • Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, et al. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004; 3:772 - 5; http://dx.doi.org/10.4161/cbt.3.8.994; PMID: 15254419
  • Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 2006; 94:455 - 9; http://dx.doi.org/10.1038/sj.bjc.6602970; PMID: 16449998
  • Samuels Y, Diaz LA Jr., Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005; 7:561 - 73; http://dx.doi.org/10.1016/j.ccr.2005.05.014; PMID: 15950905
  • Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, et al. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci U S A 2009; 106:2835 - 40; http://dx.doi.org/10.1073/pnas.0813351106; PMID: 19196980
  • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009; 9:550 - 62; http://dx.doi.org/10.1038/nrc2664; PMID: 19629070
  • Allison M. Is personalized medicine finally arriving?. Nat Biotechnol 2008; 26:509 - 17; http://dx.doi.org/10.1038/nbt0508-509; PMID: 18464779
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646 - 74; http://dx.doi.org/10.1016/j.cell.2011.02.013; PMID: 21376230
  • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789 - 99; http://dx.doi.org/10.1038/nm1087; PMID: 15286780
  • http://www.sanger.ac.uk/genetics/CGP/cosmic/
  • Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, Russo M, Cancelliere C, Zecchin D, Mazzucchelli L, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest 2010; 120:2858 - 66; http://dx.doi.org/10.1172/JCI37539; PMID: 20664172
  • Mohseni M, Park BH. PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001. J Clin Invest 2010; 120:2655 - 8; http://dx.doi.org/10.1172/JCI44026; PMID: 20664174
  • Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009; 8:627 - 44; http://dx.doi.org/10.1038/nrd2926; PMID: 19644473
  • Courtney KD, Corcoran RB, Engelman JA. The PI3K pathway as drug target in human cancer. J Clin Oncol 2010; 28:1075 - 83; http://dx.doi.org/10.1200/JCO.2009.25.3641; PMID: 20085938
  • Maira S-M, Finan P, Garcia-Echeverria C. From the bench to the bed side: PI3K pathway inhibitors in clinical development. Curr Top Microbiol Immunol 2010; 347:209 - 39; http://dx.doi.org/10.1007/82_2010_60; PMID: 20582534
  • Chavez-MacGregor M, Gonzalez-Angulo AM. Everolimus in the treatment of hormone receptor-positive breast cancer. Expert Opin Investig Drugs 2012; 21:1835 - 43; http://dx.doi.org/10.1517/13543784.2012.726218; PMID: 22994502
  • Kalinsky K, Jacks LM, Heguy A, Patil S, Drobnjak M, Bhanot UK, Hedvat CV, Traina TA, Solit D, Gerald W, et al. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 2009; 15:5049 - 59; http://dx.doi.org/10.1158/1078-0432.CCR-09-0632; PMID: 19671852
  • Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M, Ferro A, Dalla Palma P, Galligioni E, Marchetti A. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res 2007; 13:6064 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-07-0266; PMID: 17947469
  • Maruyama N, Miyoshi Y, Taguchi T, Tamaki Y, Monden M, Noguchi S. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007; 13:408 - 14; http://dx.doi.org/10.1158/1078-0432.CCR-06-0267; PMID: 17202311
  • Li SY, Rong M, Grieu F, Iacopetta B. PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006; 96:91 - 5; http://dx.doi.org/10.1007/s10549-005-9048-0; PMID: 16317585
  • Lerma E, Catasus L, Gallardo A, Peiro G, Alonso C, Aranda I, Barnadas A, Prat J. Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas. Virchows Arch 2008; 453:133 - 9; http://dx.doi.org/10.1007/s00428-008-0643-4; PMID: 18679714
  • Loi S, Haibe-Kains B, Majjaj S, Lallemand F, Durbecq V, Larsimont D, Gonzalez-Angulo AM, Pusztai L, Symmans WF, Bardelli A, et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A 2010; 107:10208 - 13; http://dx.doi.org/10.1073/pnas.0907011107; PMID: 20479250
  • Michelucci A, Di Cristofano C, Lami A, Collecchi P, Caligo A, Decarli N, Leopizzi M, Aretini P, Bertacca G, Porta RP, et al. PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases. Diagn Mol Pathol 2009; 18:200 - 5; http://dx.doi.org/10.1097/PDM.0b013e31818e5fa4; PMID: 19861897
  • Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmström PO, Mansukhani M, Enoksson J, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005; 65:2554 - 9; http://dx.doi.org/10.1158/0008-5472-CAN-04-3913; PMID: 15805248
  • Abubaker J, Bavi P, Al-Harbi S, Ibrahim M, Siraj AK, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, et al. Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population. Oncogene 2008; 27:3539 - 45; http://dx.doi.org/10.1038/sj.onc.1211013; PMID: 18193083
  • Abubaker J, Bavi P, Al-Haqawi W, Jehan Z, Munkarah A, Uddin S, Al-Kuraya KS. PIK3CA alterations in Middle Eastern ovarian cancers. Mol Cancer 2009; 8:51; http://dx.doi.org/10.1186/1476-4598-8-51; PMID: 19638206
  • Cohen Y, Merhavi-Shoham E, Avraham-Lubin BCR, Savetsky M, Frenkel S, Pe’er J, Goldenberg-Cohen N. PI3K/Akt pathway mutations in retinoblastoma. Invest Ophthalmol Vis Sci 2009; 50:5054 - 6; http://dx.doi.org/10.1167/iovs.09-3617; PMID: 19420344
  • Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS One 2009; 4:e7192; http://dx.doi.org/10.1371/journal.pone.0007192; PMID: 19784364
  • miRBase. http://www.mirbase.org/search.shtml
  • Campbell I, Qiu W, Haviv I. Genetic changes in tumour microenvironments. J Pathol 2011; 223:450 - 8; http://dx.doi.org/10.1002/path.2842; PMID: 21294119
  • Orimo A, Weinberg RA. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 2006; 5:1597 - 601; http://dx.doi.org/10.4161/cc.5.15.3112; PMID: 16880743
  • Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou X-P, Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 2002; 32:355 - 7; http://dx.doi.org/10.1038/ng1013; PMID: 12379854
  • Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007; 357:2543 - 51; http://dx.doi.org/10.1056/NEJMoa071825; PMID: 18094375
  • Qiu W, Hu M, Sridhar A, Opeskin K, Fox S, Shipitsin M, Trivett M, Thompson ER, Ramakrishna M, Gorringe KL, et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 2008; 40:650 - 5; http://dx.doi.org/10.1038/ng.117; PMID: 18408720
  • Hosein AN, Wu M, Arcand SL, Lavallée S, Hébert J, Tonin PN, Basik M. Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations. Cancer Res 2010; 70:5770 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-10-0673; PMID: 20570891
  • Hawsawi NM, Ghebeh H, Hendrayani S-F, Tulbah A, Al-Eid M, Al-Tweigeri T, Ajarim D, Alaiya A, Dermime S, Aboussekhra A. Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res 2008; 68:2717 - 25; http://dx.doi.org/10.1158/0008-5472.CAN-08-0192; PMID: 18413739

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.