The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies

Figures & data

Figure 1. Sensitivity of PCR sequencing: plasmid DNA carrying the c.1474A>C EGFR point mutation was mixed with plasmid wild-type DNA in dilutions of 50%, 20%, 10%, and 5%. Reverse sequencing chromatograms are shown.

Table 1. Patients’ clinic-pathological characteristics

Characteristics		N of patients	%
Gender	Male	296	59
	Female	209	41
Age at diagnosis	Median	58
	Range	21–95
	< 65	238	47
	≥ 65	267	53
Tumor site	Primary tumor	472	93
	Metastasis	33	7
Grading	G1	22	4
	G2	323	64
	G3	121	24
	Gx	39	8
Stage	I–III	63	12
	IV	442	8
T status*	T0	17	3
	T1	11	2
	T2	52	10
	T3	320	63
	T4	105	22
N status*	N0	168	34
	N1	178	35
	N2	153	30
	N3	6	1

*at diagnosis.