Figure 1 Approaches for cellular reprogramming. Somatic cells can be reprogrammed to pluripotent cells through somatic cell nuclear transfer (SCNT), cell fusion or ectopic expression of defined transcription factors (e.g., Oct4, Sox2, Klf4 and Myc). The recent breakthrough in the generation of iPS cells using Oct4 and chemical compounds represents a major step toward a completely small molecule-based reprogramming condition.
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