Figures & data
Figure 1. Cancer stem cells (CSCs) are key contributors to tumor chemoresistance due to their ability to survive platinum-based chemotherapies. Pictured is a graphical representation of a Notch-dependent ovarian tumor that accumulates drug-resistant CSCs (green circles) and acquires platinum resistance. Differentiated Notch-dependent non-CSC tumor cells are shown in light blue circles. McAuliffe et al.Citation7 shows that tumor sensitivity to platinum is restored when the γ-secretase complex (plum), which cleaves and activates the Notch receptor (red), is targeted with γ-secretase inhibitor I (GSI, navy blue triangles).
