Human metastable epiallele candidates link to common disorders

Figures & data

Figure 1. Metastable epiallele (ME) candidates, where epigenetic responsiveness to periconceptual maternal micronutrient supplementation was observed in the cord blood of male (A–B) and female (C) newborns (see text for details). DNA methylation from peripheral blood (mesodermal origin) DNA, and colonic mucosa (colon, endodermal origin) showed significant intraindividual correlation, but > 10% interindividual methylation differences. n = 10. C18orf22: r = 0.66, p = 0.038; PTPN20B: r = 0.97, p < 0.001; MGMT: r = 0.98, p < 0.001

Figure 2. Examples for metastable epiallele (ME) candidates with 3 or more CpG sites meeting ME criteria in close vicinity (within 10 kb) of each other. DNA methylation from peripheral blood leukocyte (mesodermal origin) DNA, and colonic mucosa (colon, endodermal origin) showed significant intraindividual correlation, but > 10% interindividual methylation differences. A. CYP2E1, where gene expression associated with DNA methylation in Parkinson disease brain. Epigenetic responsiveness to periconceptual maternal micronutrient supplementation was also observed in the cord blood of female newborns at this gene. B. HCG9, where DNA methylation associated with bipolar disorder in three different [brain, white blood cells, sperms (germ line)] tissues (see text for references and details). n = 10. CYP2E1: r = 0.8, p = 0.005; HCG9: r = 0.87, p = 0.001