Figures & data
Figure 1. Structure and activation of Estrogen Receptor. (A) Schematic representation of ERα domains and their potential interaction with co-activators/co-repressors and ERE. (B) Mechanisms of ERα activation by estrogens. Recruitment of liganded ERα on DNA is mediated directly on ERE or not directly via SP1 or NFKB interaction.
Figure 2. Model of epigenetic inactivation of ESR1. Primary methylation and recruitment of ICBP90 on ERα promoter, provoke histone deacetylation and a large secondary methylation and ERα silencing. Ac, acetylation of histones; white circles symbolize unmethylated CpGs and black circles symbolize methylated CpGs.
Figure 3. Model of ER-mediated epigenetic response in ER target genes. (A) Schematic representation of action of coactivators and corepressors. (B) Direct and indirect interactions of ERα with epigenetic related proteins.
