5,810
Views
243
CrossRef citations to date
0
Altmetric
Research Paper

A longitudinal study of epigenetic variation in twins

, , , , , , & show all
Pages 516-526 | Received 05 Mar 2010, Accepted 04 May 2010, Published online: 16 Aug 2010

Figures & data

Figure 1 Average DNA methylation level in DRD4, SERT and MAOA amplicons at ages 5 and 10 years. * Significant differences (p < 0.001) in average MAOA DNA methylation level between male and female children. MZ, monozygotic; DZ, dizygotic; MZM, monozygotic male; MZF, monozygotic female; DZM, dizygotic male; DZF, dizygotic female.

Figure 1 Average DNA methylation level in DRD4, SERT and MAOA amplicons at ages 5 and 10 years. * Significant differences (p < 0.001) in average MAOA DNA methylation level between male and female children. MZ, monozygotic; DZ, dizygotic; MZM, monozygotic male; MZF, monozygotic female; DZM, dizygotic male; DZF, dizygotic female.

Figure 2 Longitudinal analysis of DRD4 DNA methylation in MZ and DZ twins. (A) Individual changes in average DRD4 DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for DRD4 DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average DRD4 DNA methylation at age 5. (D) MZ and DZ twin correlations for average DRD4 DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in DRD4 DNA methylation from age 5 to age 10 years.

Figure 2 Longitudinal analysis of DRD4 DNA methylation in MZ and DZ twins. (A) Individual changes in average DRD4 DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for DRD4 DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average DRD4 DNA methylation at age 5. (D) MZ and DZ twin correlations for average DRD4 DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in DRD4 DNA methylation from age 5 to age 10 years.

Figure 3 Longitudinal analysis of SERT DNA methylation in MZ and DZ twins. (A) Individual changes in average SERT DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for SERT DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average SERT DNA methylation at age 5. (D) MZ and DZ twin correlations for average SERT DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in SERT DNA methylation from age 5 to age 10 years.

Figure 3 Longitudinal analysis of SERT DNA methylation in MZ and DZ twins. (A) Individual changes in average SERT DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for SERT DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average SERT DNA methylation at age 5. (D) MZ and DZ twin correlations for average SERT DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in SERT DNA methylation from age 5 to age 10 years.

Figure 4 Longitudinal analysis of MAOA DNA methylation in MZ and DZ twins, stratified by sex. (A) Individual changes in average MAOA DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for MAOA DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average MAOA DNA methylation at age 5. (D) MZ and DZ twin correlations for average MAOA DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in MAOA DNA methylation from age 5 to age 10 years. MZM, monozygotic male; MZF, monozygotic female; DZM, dizygotic male; DZF, dizygotic female.

Figure 4 Longitudinal analysis of MAOA DNA methylation in MZ and DZ twins, stratified by sex. (A) Individual changes in average MAOA DNA methylation between ages 5 and 10 years. (B) Inter-individual stability correlations for MAOA DNA methylation, between ages 5 and 10 years. (C) MZ and DZ twin correlations for average MAOA DNA methylation at age 5. (D) MZ and DZ twin correlations for average MAOA DNA methylation at age 10. (E) MZ and DZ twin correlations for intraindividual change in MAOA DNA methylation from age 5 to age 10 years. MZM, monozygotic male; MZF, monozygotic female; DZM, dizygotic male; DZF, dizygotic female.
Supplemental material

Additional material

Download Zip (45.2 KB)