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Commentary

Flying back to the nest

Intravital microscopy reveals how the niche can induce stemness

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Article: e29653 | Received 16 Apr 2014, Accepted 19 Jun 2014, Published online: 11 Aug 2014

Figures & data

Figure 1. Normally, all cells within the niche can act as stem cells, however those on the periphery of the niche have the higher chance of leaving the niche and differentiating. Conversely, should the stem cells be lost and the niche become vacant, differentiating cells can migrate into the niche and become new stem cells.

Figure 1. Normally, all cells within the niche can act as stem cells, however those on the periphery of the niche have the higher chance of leaving the niche and differentiating. Conversely, should the stem cells be lost and the niche become vacant, differentiating cells can migrate into the niche and become new stem cells.